CO5540342A2 - Compuestos derivados de tetraisoquinolina que son agentes hipoglicemiantes e hipolipidemicos, y composiciones farmaceuticas que los contienen - Google Patents
Compuestos derivados de tetraisoquinolina que son agentes hipoglicemiantes e hipolipidemicos, y composiciones farmaceuticas que los contienenInfo
- Publication number
- CO5540342A2 CO5540342A2 CO03112806A CO03112806A CO5540342A2 CO 5540342 A2 CO5540342 A2 CO 5540342A2 CO 03112806 A CO03112806 A CO 03112806A CO 03112806 A CO03112806 A CO 03112806A CO 5540342 A2 CO5540342 A2 CO 5540342A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- hydrogen atom
- aryl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un nuevo compuesto heterociclico de la fórmula (I) dondeR1 es un átomo de hidrógeno o alquilo C1-6;R2 un átomo de hidrógeno, -CO-R3, donde R3 es alquilo C2-6 opcionalmente sustituido por halógeno, -CO-C(R4)=(C(R4)-R5, donde R4 es opcionalmente el mismo que el otro R4 y es un átomo de hidrógeno o alquilo C1-4, y R5 es alquilo C1-6, alquenilo C2-8, alquenilo C2-8, arilo o un heterociclo aromático, -CO-C=C-R6, donde R6 es alquilo C1-8, donde m es un número entero de 2 a 7, arilo, arilalquilo C1-3 opcionalmente sustituido, alquilo C1-6 opcionalmente sustituido por halógeno, alquenilo C2-6, cicloalquilo C3-8 o cicloalquil C3-8-alquilo C1-3;Y es Donde R7 es un átomo de hidrógeno o alquilo C1-4, R8 es alquilo C5-8, cicloalquilo C4-8, alquiltio C1-4-alquilo C1-6, R10-C(R9)=C(R9)-, donde R9 es opcionalmente el mismo que el otro R9 y es un átomo de hidrógeno o alquilo C1-4 y R10 es alquilo C1-4 opcionalmente sustituido por halógeno, alquenilo C2-9, arilo, un heterociclo aromático, cicloalquilo C3-8, cicloalquil C3-8-alquilo C1-3, alcoxi C1-4-alquilo C1-4-alquilo C1-6, alquiltio C1-4-alquilo C1-6 o alquilo C1-6 sustituido por (R9)2N-, donde R9 es opcionalmente el mismo que el otro R9 y es un átomo de hidrógeno o alquilo C1-4, R12-CO-N(R11)-, donde R11 es un átomo de hidrógeno o alquilo C1-4 y R12 es alquilo C1-6 o arilo, R13-Z-, donde R13 es alquilo C1-8 o arilo y Z es un átomo de oxígeno o un átomo de azufre, o donde k es un número entero de 2 a 7 y X es un átomo de oxígeno o un átomo de azufre, oR15-C(R14)=N-O-, donde R14 es un átomo de hidrógeno o alquilo C1-4 y R15 es arilo o un heterociclo aromático; Y-(CH2)n-O- esta enlazado a la posición 6 ó 7 de un esqueleto de tetrahidroisoquinolina; yn es un número entero de 1 a 4,o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001161489 | 2001-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5540342A2 true CO5540342A2 (es) | 2005-07-29 |
Family
ID=19004756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03112806A CO5540342A2 (es) | 2001-05-29 | 2003-12-29 | Compuestos derivados de tetraisoquinolina que son agentes hipoglicemiantes e hipolipidemicos, y composiciones farmaceuticas que los contienen |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7557123B2 (es) |
| EP (1) | EP1403253A4 (es) |
| JP (1) | JP4279136B2 (es) |
| KR (2) | KR100898358B1 (es) |
| CN (1) | CN1242994C (es) |
| AR (1) | AR036036A1 (es) |
| AU (1) | AU2002308889B2 (es) |
| BR (1) | BR0209711A (es) |
| CA (1) | CA2448634A1 (es) |
| CO (1) | CO5540342A2 (es) |
| CZ (1) | CZ20033450A3 (es) |
| HK (1) | HK1069385A1 (es) |
| HU (1) | HUP0401862A3 (es) |
| IL (1) | IL159085A0 (es) |
| MX (1) | MXPA03010811A (es) |
| NO (1) | NO326688B1 (es) |
| NZ (1) | NZ530358A (es) |
| PL (1) | PL367639A1 (es) |
| RU (1) | RU2299197C2 (es) |
| TW (1) | TWI297008B (es) |
| WO (1) | WO2002096880A1 (es) |
| YU (1) | YU94003A (es) |
| ZA (1) | ZA200309757B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522253A (zh) | 2001-05-29 | 2004-08-18 | ����ҩƷ��ҵ��ʽ���� | 新颖的杂环衍生物及其医疗用途 |
| US7816385B2 (en) * | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
| JPWO2004106542A1 (ja) * | 2003-05-29 | 2006-07-20 | 三共株式会社 | インスリン抵抗性改善剤及びそのスクリーニング方法 |
| TWI359810B (en) * | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| US7790745B2 (en) * | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| WO2007058504A1 (en) * | 2005-11-21 | 2007-05-24 | Lg Life Sciences, Ltd. | Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same |
| JPWO2012033195A1 (ja) * | 2010-09-10 | 2014-01-20 | 京都薬品工業株式会社 | 複素環化合物 |
| CN102807526B (zh) * | 2011-06-21 | 2015-12-02 | 寿光富康制药有限公司 | 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用 |
| WO2020013116A1 (ja) * | 2018-07-10 | 2020-01-16 | 京都薬品工業株式会社 | Ｐｔｐ－１ｂ阻害剤およびその用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| DE10199003I1 (de) * | 1987-09-04 | 2003-06-12 | Beecham Group Plc | Substituierte Thiazolidinionderivate |
| US5246943A (en) | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| IL121202A (en) | 1996-07-01 | 2001-08-26 | Lilly Co Eli | Hypoglycemic and hypolipidemic compounds, process for their preparation, pharmaceutial compositions comprising same, and uses thereof |
| DE69731003D1 (de) * | 1996-07-01 | 2004-11-04 | Lilly Co Eli | Blutzuckersenkende und lipidsenkende verbindungen |
| GB9817118D0 (en) | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| AU782631C (en) | 1999-12-03 | 2006-08-17 | Kyoto Pharmaceutical Industries, Ltd. | Novel heterocyclic compounds and salts thereof and medicinal use of the same |
| US20020037897A1 (en) * | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| CN1522253A (zh) | 2001-05-29 | 2004-08-18 | ����ҩƷ��ҵ��ʽ���� | 新颖的杂环衍生物及其医疗用途 |
-
2002
- 2002-05-27 IL IL15908502A patent/IL159085A0/xx unknown
- 2002-05-27 RU RU2003137574/04A patent/RU2299197C2/ru not_active IP Right Cessation
- 2002-05-27 BR BR0209711-7A patent/BR0209711A/pt not_active IP Right Cessation
- 2002-05-27 AU AU2002308889A patent/AU2002308889B2/en not_active Ceased
- 2002-05-27 CZ CZ20033450A patent/CZ20033450A3/cs unknown
- 2002-05-27 JP JP2003500060A patent/JP4279136B2/ja not_active Expired - Fee Related
- 2002-05-27 WO PCT/JP2002/005097 patent/WO2002096880A1/ja active Application Filing
- 2002-05-27 EP EP02774070A patent/EP1403253A4/en not_active Withdrawn
- 2002-05-27 PL PL02367639A patent/PL367639A1/xx unknown
- 2002-05-27 ZA ZA200309757A patent/ZA200309757B/en unknown
- 2002-05-27 HU HU0401862A patent/HUP0401862A3/hu unknown
- 2002-05-27 CA CA002448634A patent/CA2448634A1/en not_active Abandoned
- 2002-05-27 YU YU94003A patent/YU94003A/sh unknown
- 2002-05-27 CN CNB028109643A patent/CN1242994C/zh not_active Expired - Fee Related
- 2002-05-27 US US10/478,862 patent/US7557123B2/en not_active Expired - Fee Related
- 2002-05-27 KR KR1020087023698A patent/KR100898358B1/ko not_active IP Right Cessation
- 2002-05-27 NZ NZ530358A patent/NZ530358A/en unknown
- 2002-05-27 MX MXPA03010811A patent/MXPA03010811A/es active IP Right Grant
- 2002-05-27 KR KR10-2003-7015611A patent/KR20040030647A/ko not_active IP Right Cessation
- 2002-05-28 TW TW091111315A patent/TWI297008B/zh active
- 2002-05-29 AR ARP020102002A patent/AR036036A1/es unknown
-
2003
- 2003-11-28 NO NO20035331A patent/NO326688B1/no not_active IP Right Cessation
- 2003-12-29 CO CO03112806A patent/CO5540342A2/es not_active Application Discontinuation
-
2005
- 2005-03-02 HK HK05101815A patent/HK1069385A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO326688B1 (no) | 2009-01-26 |
| JP4279136B2 (ja) | 2009-06-17 |
| CN1242994C (zh) | 2006-02-22 |
| CZ20033450A3 (cs) | 2004-05-12 |
| US20040220215A1 (en) | 2004-11-04 |
| HUP0401862A3 (en) | 2009-03-30 |
| NZ530358A (en) | 2005-04-29 |
| KR20080093076A (ko) | 2008-10-17 |
| RU2003137574A (ru) | 2005-05-20 |
| YU94003A (sh) | 2006-08-17 |
| MXPA03010811A (es) | 2004-02-27 |
| AR036036A1 (es) | 2004-08-04 |
| US7557123B2 (en) | 2009-07-07 |
| AU2002308889B2 (en) | 2007-09-06 |
| WO2002096880A1 (fr) | 2002-12-05 |
| HK1069385A1 (en) | 2005-05-20 |
| ZA200309757B (en) | 2004-12-22 |
| BR0209711A (pt) | 2004-11-03 |
| HUP0401862A2 (hu) | 2004-12-28 |
| EP1403253A1 (en) | 2004-03-31 |
| EP1403253A4 (en) | 2005-03-30 |
| NO20035331D0 (no) | 2003-11-28 |
| IL159085A0 (en) | 2004-05-12 |
| JPWO2002096880A1 (ja) | 2004-09-09 |
| PL367639A1 (en) | 2005-03-07 |
| TWI297008B (en) | 2008-05-21 |
| CA2448634A1 (en) | 2002-12-05 |
| CN1527819A (zh) | 2004-09-08 |
| RU2299197C2 (ru) | 2007-05-20 |
| KR20040030647A (ko) | 2004-04-09 |
| KR100898358B1 (ko) | 2009-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |