MXPA03010811A - Compuestos heterociclico y uso farmaceutico. - Google Patents

Compuestos heterociclico y uso farmaceutico.

Info

Publication number
MXPA03010811A
MXPA03010811A MXPA03010811A MXPA03010811A MXPA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A
Authority
MX
Mexico
Prior art keywords
agent
alkyl
remedy
same meaning
heterocyclic compound
Prior art date
Application number
MXPA03010811A
Other languages
English (en)
Inventor
Matsui Hiroshi
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of MXPA03010811A publication Critical patent/MXPA03010811A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El nuevo compuesto heterociclico de la presente invencion es un nuevo compuesto heterociclico que tiene la formula (I) (ver formula) donde R1 es H o alquilo C1-6, R7 es H, -CO-C(R4)=C(R4)-R5, donde R4 es H o alquilo C1-4, y R5 es alquilo C4-8, alquenilo C2-8 y similares, y otros, y es el siguiente grupo, donde X es O u S, R7, es el mismo que R4, R8 es R10-C(R9)=C(R9)-, donde R9 es el mismo que R4, R10 es C1-6 alquilo y similares, y otros, R14 es el mismo que R4 y R15 es arilo y similares, Y-(CH7)n-O- esta enlazado a la posicion 6 o 7 del esqueleto de la tetrahidroisoquinolina, y n es un numero entero de 1 a 4, o una sal farmaceuticamente aceptable del mismo. El compuesto (I) de la presente invencion es util como agente hipoglucemico, agente hipolipidemico, mejorador de la resistencia a la insulina, agente terapeutico de la diabetes, agente terapeutico de complicaciones diabeticas, mejorador de la tolerancia a la glucosa, agente antiarterioesclerosis, agente antiobesidad, agente antiinflamatorio, agente para la profilaxis o tratamiento de enfermedades mediadas por PPAR o agente para la profilaxis o el tratamiento del sindrome X.
MXPA03010811A 2001-05-29 2002-05-27 Compuestos heterociclico y uso farmaceutico. MXPA03010811A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001161489 2001-05-29
PCT/JP2002/005097 WO2002096880A1 (fr) 2001-05-29 2002-05-27 Nouveau compose heterocyclique et son utilisation medicinale

Publications (1)

Publication Number Publication Date
MXPA03010811A true MXPA03010811A (es) 2004-02-27

Family

ID=19004756

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010811A MXPA03010811A (es) 2001-05-29 2002-05-27 Compuestos heterociclico y uso farmaceutico.

Country Status (23)

Country Link
US (1) US7557123B2 (es)
EP (1) EP1403253A4 (es)
JP (1) JP4279136B2 (es)
KR (2) KR100898358B1 (es)
CN (1) CN1242994C (es)
AR (1) AR036036A1 (es)
AU (1) AU2002308889B2 (es)
BR (1) BR0209711A (es)
CA (1) CA2448634A1 (es)
CO (1) CO5540342A2 (es)
CZ (1) CZ20033450A3 (es)
HK (1) HK1069385A1 (es)
HU (1) HUP0401862A3 (es)
IL (1) IL159085A0 (es)
MX (1) MXPA03010811A (es)
NO (1) NO326688B1 (es)
NZ (1) NZ530358A (es)
PL (1) PL367639A1 (es)
RU (1) RU2299197C2 (es)
TW (1) TWI297008B (es)
WO (1) WO2002096880A1 (es)
YU (1) YU94003A (es)
ZA (1) ZA200309757B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1522253A (zh) 2001-05-29 2004-08-18 ����ҩƷ��ҵ��ʽ���� 新颖的杂环衍生物及其医疗用途
US7816385B2 (en) * 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
JPWO2004106542A1 (ja) * 2003-05-29 2006-07-20 三共株式会社 インスリン抵抗性改善剤及びそのスクリーニング方法
TWI359810B (en) * 2004-11-04 2012-03-11 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivative containing thiazole rin
US7790745B2 (en) * 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
WO2007058504A1 (en) * 2005-11-21 2007-05-24 Lg Life Sciences, Ltd. Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same
JPWO2012033195A1 (ja) * 2010-09-10 2014-01-20 京都薬品工業株式会社 複素環化合物
CN102807526B (zh) * 2011-06-21 2015-12-02 寿光富康制药有限公司 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用
WO2020013116A1 (ja) * 2018-07-10 2020-01-16 京都薬品工業株式会社 Ptp-1b阻害剤およびその用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
DE10199003I1 (de) * 1987-09-04 2003-06-12 Beecham Group Plc Substituierte Thiazolidinionderivate
US5246943A (en) 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
IL121202A (en) 1996-07-01 2001-08-26 Lilly Co Eli Hypoglycemic and hypolipidemic compounds, process for their preparation, pharmaceutial compositions comprising same, and uses thereof
DE69731003D1 (de) * 1996-07-01 2004-11-04 Lilly Co Eli Blutzuckersenkende und lipidsenkende verbindungen
GB9817118D0 (en) 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
AU782631C (en) 1999-12-03 2006-08-17 Kyoto Pharmaceutical Industries, Ltd. Novel heterocyclic compounds and salts thereof and medicinal use of the same
US20020037897A1 (en) * 2000-08-07 2002-03-28 3-Dimensional Pharmaceuticals, Inc. Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
CN1522253A (zh) 2001-05-29 2004-08-18 ����ҩƷ��ҵ��ʽ���� 新颖的杂环衍生物及其医疗用途

Also Published As

Publication number Publication date
NO326688B1 (no) 2009-01-26
JP4279136B2 (ja) 2009-06-17
CN1242994C (zh) 2006-02-22
CZ20033450A3 (cs) 2004-05-12
US20040220215A1 (en) 2004-11-04
HUP0401862A3 (en) 2009-03-30
NZ530358A (en) 2005-04-29
KR20080093076A (ko) 2008-10-17
RU2003137574A (ru) 2005-05-20
YU94003A (sh) 2006-08-17
CO5540342A2 (es) 2005-07-29
AR036036A1 (es) 2004-08-04
US7557123B2 (en) 2009-07-07
AU2002308889B2 (en) 2007-09-06
WO2002096880A1 (fr) 2002-12-05
HK1069385A1 (en) 2005-05-20
ZA200309757B (en) 2004-12-22
BR0209711A (pt) 2004-11-03
HUP0401862A2 (hu) 2004-12-28
EP1403253A1 (en) 2004-03-31
EP1403253A4 (en) 2005-03-30
NO20035331D0 (no) 2003-11-28
IL159085A0 (en) 2004-05-12
JPWO2002096880A1 (ja) 2004-09-09
PL367639A1 (en) 2005-03-07
TWI297008B (en) 2008-05-21
CA2448634A1 (en) 2002-12-05
CN1527819A (zh) 2004-09-08
RU2299197C2 (ru) 2007-05-20
KR20040030647A (ko) 2004-04-09
KR100898358B1 (ko) 2009-05-20

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