PE20090770A1 - Derivados de benzoxazolona - Google Patents

Derivados de benzoxazolona

Info

Publication number
PE20090770A1
PE20090770A1 PE2008000958A PE2008000958A PE20090770A1 PE 20090770 A1 PE20090770 A1 PE 20090770A1 PE 2008000958 A PE2008000958 A PE 2008000958A PE 2008000958 A PE2008000958 A PE 2008000958A PE 20090770 A1 PE20090770 A1 PE 20090770A1
Authority
PE
Peru
Prior art keywords
ilmethyl
piperazin
hal
oxo
phenyl
Prior art date
Application number
PE2008000958A
Other languages
English (en)
Inventor
Oliver Schadt
Dieter Dorsch
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PE20090770A1 publication Critical patent/PE20090770A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE E, E', E'', E''' SON CADA UNO C, N; R1 Y R2 SON CADA UNO H, A, ENTRE OTROS; R3 ES H, A, OH, OA, ENTRE OTROS; R3' ES H, HAL; R4 ES HETEROCICLO AROMATICO MONOCICLICO CON 1-4 ATOMOS DE N, O, S, NO2, ENTRE OTROS; R4' ES H, HAL; A ES ALQUILO RAMIFICADO O NO, CICLOALQUILO C3-C7, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ESTER 3-(4-METIL-PIPERAZIN-1-IL)-PROPILICO DEL ACIDO [3-(5-METOXI-2-OXO-BENZOXAZOL-3-ILMETIL)-FENIL]-CARBAMICO; ESTER 3-(4-METIL-PIPERAZIN-1-IL)-PROPILICO DEL ACIDO [3-(5-PROPILCARBAMOIL-2-OXO-BENZOXAZOLL-3-ILMETIL)-FENIL]-CARBAMICO; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE TIROSINA QUINASAS UTIL EN EL TRATAMIENTO DE TUMORES
PE2008000958A 2007-06-06 2008-06-05 Derivados de benzoxazolona PE20090770A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007026341A DE102007026341A1 (de) 2007-06-06 2007-06-06 Benzoxazolonderivate

Publications (1)

Publication Number Publication Date
PE20090770A1 true PE20090770A1 (es) 2009-06-24

Family

ID=39739806

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000958A PE20090770A1 (es) 2007-06-06 2008-06-05 Derivados de benzoxazolona

Country Status (18)

Country Link
US (2) US8071593B2 (es)
EP (1) EP2150551B1 (es)
JP (1) JP5662143B2 (es)
KR (1) KR20100031531A (es)
CN (1) CN101679401B (es)
AR (1) AR066892A1 (es)
AU (1) AU2008258366B2 (es)
BR (1) BRPI0812293A2 (es)
CA (1) CA2689554C (es)
DE (1) DE102007026341A1 (es)
EA (1) EA200901611A1 (es)
ES (1) ES2402540T3 (es)
IL (1) IL202505A (es)
MX (1) MX2009013077A (es)
PE (1) PE20090770A1 (es)
TW (1) TW200848030A (es)
WO (1) WO2008148449A1 (es)
ZA (1) ZA201000085B (es)

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WO2014200872A1 (en) * 2013-06-09 2014-12-18 Rjs Biologics Llc Pharmaceutical compounds targeted by mif affinity-tethered moieties
WO2016091891A1 (en) 2014-12-09 2016-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies against axl
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
JP2020524718A (ja) * 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ ヒトｓｔｉｎｇの複素環式小分子調節因子
US11180480B2 (en) 2017-10-17 2021-11-23 Sensorion Synthesis of 4-aminopyrimidine compounds
WO2020186202A1 (en) * 2019-03-14 2020-09-17 Board Of Regents, The University Of Texas System Small molecule grb2 stabilizers for ras map kinase inhibition
CN115490578B (zh) * 2022-09-23 2023-12-22 江苏理工学院 一种碳同位素标记的三氯生的制备方法

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Also Published As

Publication number Publication date
AU2008258366B2 (en) 2013-02-21
TW200848030A (en) 2008-12-16
DE102007026341A1 (de) 2008-12-11
AU2008258366A1 (en) 2008-12-11
EP2150551B1 (de) 2013-01-16
CA2689554C (en) 2015-12-01
EA200901611A1 (ru) 2010-06-30
AR066892A1 (es) 2009-09-16
EP2150551A1 (de) 2010-02-10
CN101679401B (zh) 2012-12-12
CA2689554A1 (en) 2008-12-11
US8431572B2 (en) 2013-04-30
BRPI0812293A2 (pt) 2014-11-25
IL202505A (en) 2014-11-30
MX2009013077A (es) 2010-01-15
US20110263596A1 (en) 2011-10-27
CN101679401A (zh) 2010-03-24
ZA201000085B (en) 2010-09-29
US8071593B2 (en) 2011-12-06
IL202505A0 (en) 2010-06-30
US20100280030A1 (en) 2010-11-04
WO2008148449A1 (de) 2008-12-11
JP2010529051A (ja) 2010-08-26
JP5662143B2 (ja) 2015-01-28
ES2402540T3 (es) 2013-05-06
KR20100031531A (ko) 2010-03-22

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