MX2010004017A - 5-cianotienopiridinas para el tratamiento de tumores. - Google Patents
5-cianotienopiridinas para el tratamiento de tumores.Info
- Publication number
- MX2010004017A MX2010004017A MX2010004017A MX2010004017A MX2010004017A MX 2010004017 A MX2010004017 A MX 2010004017A MX 2010004017 A MX2010004017 A MX 2010004017A MX 2010004017 A MX2010004017 A MX 2010004017A MX 2010004017 A MX2010004017 A MX 2010004017A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- thienopyridines
- cyano
- tumors
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Las nuevas 5-ciano-tienopiridinas de la f?rmula I (ver f?rmula (I)) en donde R1, R2 y R3 tienen los significados indicados en la reivindicaci?n 1, son inhibidores de la quinasa del receptor TGF-beta, y se pueden emplear, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007049451A DE102007049451A1 (de) | 2007-10-16 | 2007-10-16 | 5-Cyano-thienopyridine |
PCT/EP2008/007888 WO2009049743A1 (de) | 2007-10-16 | 2008-09-19 | 5-cyano-thienopyridine zur behandlung von tumoren |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010004017A true MX2010004017A (es) | 2010-04-27 |
Family
ID=40262956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010004017A MX2010004017A (es) | 2007-10-16 | 2008-09-19 | 5-cianotienopiridinas para el tratamiento de tumores. |
Country Status (16)
Country | Link |
---|---|
US (1) | US8202882B2 (es) |
EP (1) | EP2197886B1 (es) |
JP (1) | JP5480811B2 (es) |
KR (1) | KR20100076026A (es) |
CN (1) | CN101827851A (es) |
AR (1) | AR068872A1 (es) |
AU (1) | AU2008314245B2 (es) |
BR (1) | BRPI0818170A2 (es) |
CA (1) | CA2702551A1 (es) |
DE (1) | DE102007049451A1 (es) |
EA (1) | EA201000618A1 (es) |
ES (1) | ES2401936T3 (es) |
IL (1) | IL205137A0 (es) |
MX (1) | MX2010004017A (es) |
WO (1) | WO2009049743A1 (es) |
ZA (1) | ZA201003425B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7904970B2 (en) | 2009-02-20 | 2011-03-15 | J-Brem, LLC | Headwear with features for holding eyeglasses |
KR20120124469A (ko) | 2010-02-05 | 2012-11-13 | 메르크 파텐트 게엠베하 | 헤트아릴-[1,8]나프티리딘 유도체 |
AU2011217561B2 (en) | 2010-02-22 | 2016-04-21 | Merck Patent Gmbh | Hetarylaminonaphthyridines |
SG11201405918XA (en) * | 2012-03-20 | 2014-10-30 | Seragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
US9801863B2 (en) | 2012-04-16 | 2017-10-31 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis |
WO2014111037A1 (zh) * | 2013-01-18 | 2014-07-24 | 上海昀怡健康管理咨询有限公司 | 五元并六元杂环化合物、其制备方法、药物组合物和应用 |
AU2014342811B2 (en) | 2013-10-15 | 2019-01-03 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
EP3267995A4 (en) | 2015-03-08 | 2019-02-27 | Case Western Reserve University | INHIBITORS OF SHORT CHAIN DEHYDROGENASE ACTIVITY FOR THE TREATMENT OF FIBROSIS |
WO2018102552A1 (en) | 2016-11-30 | 2018-06-07 | Case Western Reserve University | Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof |
CA3052466A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
GB0323810D0 (en) | 2003-10-10 | 2003-11-12 | Cancer Rec Tech Ltd | Pyridothiophene compounds |
WO2005058315A1 (en) | 2003-12-12 | 2005-06-30 | Ribapharm, Inc. | Novel heterocyclic compounds as ikk2 inhibitors with anti-hbv activity |
DE102005009440A1 (de) * | 2005-03-02 | 2006-09-07 | Merck Patent Gmbh | Thienopyridinderivate |
DE102005024245A1 (de) | 2005-05-27 | 2006-11-30 | Merck Patent Gmbh | Thienopyridine |
-
2007
- 2007-10-16 DE DE102007049451A patent/DE102007049451A1/de not_active Withdrawn
-
2008
- 2008-09-19 WO PCT/EP2008/007888 patent/WO2009049743A1/de active Application Filing
- 2008-09-19 US US12/738,158 patent/US8202882B2/en not_active Expired - Fee Related
- 2008-09-19 EA EA201000618A patent/EA201000618A1/ru unknown
- 2008-09-19 BR BRPI0818170A patent/BRPI0818170A2/pt not_active IP Right Cessation
- 2008-09-19 MX MX2010004017A patent/MX2010004017A/es not_active Application Discontinuation
- 2008-09-19 ES ES08802398T patent/ES2401936T3/es active Active
- 2008-09-19 CN CN200880112035A patent/CN101827851A/zh active Pending
- 2008-09-19 AU AU2008314245A patent/AU2008314245B2/en not_active Ceased
- 2008-09-19 JP JP2010529253A patent/JP5480811B2/ja not_active Expired - Fee Related
- 2008-09-19 CA CA2702551A patent/CA2702551A1/en not_active Abandoned
- 2008-09-19 EP EP08802398A patent/EP2197886B1/de not_active Not-in-force
- 2008-09-19 KR KR1020107010661A patent/KR20100076026A/ko not_active Application Discontinuation
- 2008-10-15 AR ARP080104485A patent/AR068872A1/es unknown
-
2010
- 2010-04-15 IL IL205137A patent/IL205137A0/en unknown
- 2010-05-14 ZA ZA2010/03425A patent/ZA201003425B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR068872A1 (es) | 2009-12-09 |
CA2702551A1 (en) | 2009-04-23 |
ZA201003425B (en) | 2011-04-28 |
JP5480811B2 (ja) | 2014-04-23 |
IL205137A0 (en) | 2010-11-30 |
AU2008314245B2 (en) | 2013-07-18 |
BRPI0818170A2 (pt) | 2017-05-16 |
EP2197886A1 (de) | 2010-06-23 |
US20100234369A1 (en) | 2010-09-16 |
KR20100076026A (ko) | 2010-07-05 |
JP2011500610A (ja) | 2011-01-06 |
EP2197886B1 (de) | 2012-12-26 |
DE102007049451A1 (de) | 2009-04-23 |
AU2008314245A1 (en) | 2009-04-23 |
ES2401936T3 (es) | 2013-04-25 |
US8202882B2 (en) | 2012-06-19 |
CN101827851A (zh) | 2010-09-08 |
EA201000618A1 (ru) | 2011-04-29 |
WO2009049743A1 (de) | 2009-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |