ATE542800T1 - Kinasehemmer und ihre anwendungsverfahren - Google Patents
Kinasehemmer und ihre anwendungsverfahrenInfo
- Publication number
- ATE542800T1 ATE542800T1 AT07762713T AT07762713T ATE542800T1 AT E542800 T1 ATE542800 T1 AT E542800T1 AT 07762713 T AT07762713 T AT 07762713T AT 07762713 T AT07762713 T AT 07762713T AT E542800 T1 ATE542800 T1 AT E542800T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- application
- kinase inhibitors
- kinases
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76371206P | 2006-01-31 | 2006-01-31 | |
PCT/US2007/002272 WO2007089646A1 (en) | 2006-01-31 | 2007-01-26 | Kinase inhibitors and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE542800T1 true ATE542800T1 (de) | 2012-02-15 |
Family
ID=38037453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07762713T ATE542800T1 (de) | 2006-01-31 | 2007-01-26 | Kinasehemmer und ihre anwendungsverfahren |
Country Status (27)
Country | Link |
---|---|
US (2) | US8044083B2 (de) |
EP (1) | EP1981851B1 (de) |
JP (1) | JP5131990B2 (de) |
KR (1) | KR101357465B1 (de) |
CN (1) | CN101415685B (de) |
AT (1) | ATE542800T1 (de) |
AU (1) | AU2007210073B2 (de) |
BR (1) | BRPI0707401B8 (de) |
CA (1) | CA2635813C (de) |
CY (1) | CY1112770T1 (de) |
DK (1) | DK1981851T3 (de) |
ES (1) | ES2379656T3 (de) |
HK (1) | HK1123548A1 (de) |
HR (1) | HRP20120256T1 (de) |
IL (3) | IL192949A (de) |
MY (1) | MY151835A (de) |
NZ (1) | NZ570846A (de) |
PL (1) | PL1981851T3 (de) |
PT (1) | PT1981851E (de) |
RS (1) | RS52298B (de) |
RU (1) | RU2442777C2 (de) |
SG (1) | SG175599A1 (de) |
SI (1) | SI1981851T1 (de) |
TW (1) | TWI388557B (de) |
UA (1) | UA94733C2 (de) |
WO (1) | WO2007089646A1 (de) |
ZA (1) | ZA200806507B (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
UA94733C2 (ru) | 2006-01-31 | 2011-06-10 | Эррей Биофарма Инк. | Ингибиторы киназы и способы их использования |
WO2009015000A1 (en) * | 2007-07-25 | 2009-01-29 | Array Biopharma Inc. | Pyrazole urea derivatives used as kinase inhibitors |
EP2196461A1 (de) | 2008-12-15 | 2010-06-16 | Bayer CropScience AG | 4-Amino-1,2,3-benzoxathiazin-Derivate als Pestizide |
CN103649076B (zh) | 2011-05-13 | 2015-09-09 | 阵列生物制药公司 | 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物 |
KR102477065B1 (ko) * | 2012-03-01 | 2022-12-13 | 어레이 바이오파마 인크. | 1-(3-tert-부틸-1-p-톨릴-1H-피라졸-5-일)-3-(5-플루오로-2-(1-(2-하이드록시에틸)-1H-인다졸-5-일옥시)벤질)우레아 하이드로클로라이드의 결정 형태 |
WO2014134313A1 (en) | 2013-02-27 | 2014-09-04 | Array Biopharma Inc. | Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof |
PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
WO2019114792A1 (zh) | 2017-12-13 | 2019-06-20 | 劲方医药科技(上海)有限公司 | 一种TGF-βRI抑制剂的晶型、盐型及其制备方法 |
WO2023084459A1 (en) | 2021-11-15 | 2023-05-19 | Pfizer Inc. | Methods of treating sars-cov-2 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3755332A (en) | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
JPS5998060A (ja) | 1982-11-27 | 1984-06-06 | Fujisawa Pharmaceut Co Ltd | インダゾ−ル誘導体、その製造法および農薬 |
US4571255A (en) | 1983-12-29 | 1986-02-18 | Ppg Industries, Inc. | Subsituted phenoxybenzisoxazole herbicides |
US5234942A (en) | 1984-10-19 | 1993-08-10 | Ici Americas Inc. | Heterocyclic amides and leucotriene antagonistic use thereof |
SU1545940A3 (ru) | 1984-10-19 | 1990-02-23 | Ай-Си-Ай Америказ Инк (Фирма) | Способ получени гетероциклических кислот или их солей |
GB8524157D0 (en) | 1984-10-19 | 1985-11-06 | Ici America Inc | Heterocyclic amides |
PL265549A1 (en) | 1985-03-26 | 1988-09-01 | The method of manufacture of new heterocyclic amides | |
JPS6368568A (ja) | 1986-09-10 | 1988-03-28 | Otsuka Pharmaceut Factory Inc | p−アミノフエノ−ル誘導体 |
NZ224714A (en) | 1987-06-01 | 1990-03-27 | Janssen Pharmaceutica Nv | Substituted benzotriazole derivatives and pharmaceutical compositions |
IE910278A1 (en) | 1990-02-16 | 1991-08-28 | Ici Plc | Heterocyclic compounds |
US6194439B1 (en) | 1991-05-29 | 2001-02-27 | Pfizer Inc. | Tricyclic polyhydroxylic tyrosine kinase inhibitors |
CA2116863A1 (en) | 1992-07-03 | 1994-01-20 | Sumio Yokota | Condensed heterocyclic derivatives and herbicides |
US5587392A (en) | 1994-05-27 | 1996-12-24 | Mochida Pharmaceutical Co., Ltd. | Azolyl methyl phenyl derivatives having aromatase inhibitory activity |
US6083949A (en) | 1995-10-06 | 2000-07-04 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
AU702146B2 (en) | 1995-10-06 | 1999-02-11 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
EA002113B1 (ru) | 1996-09-04 | 2001-12-24 | Пфайзер Инк. | Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно) |
AU733551B2 (en) | 1996-09-25 | 2001-05-17 | Astrazeneca Ab | Qinoline derivatives inhibiting the effect of growth factors such as VEGF |
US6218386B1 (en) | 1996-11-08 | 2001-04-17 | Dupont Pharmaceuticals | A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor |
CN1235602A (zh) | 1996-11-08 | 1999-11-17 | 杜邦药品公司 | 1-(3-氨基吲唑-5-基)-3-苯甲基-环脲作为hiv蛋白酶抑制剂 |
US5932570A (en) | 1996-11-08 | 1999-08-03 | Dupont Pharmaceuticals Company | 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors |
US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
IL132318A0 (en) | 1997-04-24 | 2001-03-19 | Ortho Mcneil Pharm Inc | Substituted imidazoles useful in the treatment of inflammatory diseases |
JP2002502380A (ja) | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | p38キナーゼ阻害剤としてのピラゾール誘導体 |
US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
EP1025102B1 (de) | 1997-10-20 | 2004-05-19 | F. Hoffmann-La Roche Ag | Bicyclische kinase inhibitoren |
AU1367599A (en) | 1997-11-03 | 1999-05-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
JP2001521926A (ja) | 1997-11-04 | 2001-11-13 | ファイザー・プロダクツ・インク | 治療上活性の化合物におけるカテコールのインダゾール生物学的等価物置換 |
NZ503995A (en) | 1997-11-04 | 2003-02-28 | Pfizer Prod Inc | Indazole compounds, and pharmaceutical compositions and uses thereof, based on indazole bioisostere replacement of catechol in PDE4 inhibitors |
US6329412B1 (en) | 1997-11-04 | 2001-12-11 | Pfizer Inc | Bisamidine compounds as antiproliferative agents |
US6589954B1 (en) | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
GB9820767D0 (en) | 1998-09-23 | 1998-11-18 | Cerebrus Ltd | Chemical compounds VIII |
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
JP2002537397A (ja) | 1999-02-22 | 2002-11-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症剤としての多環ヘテロ環式誘導体 |
ATE309237T1 (de) | 1999-03-12 | 2005-11-15 | Boehringer Ingelheim Pharma | Aromatische heterozyklische verbindungen als antientzündungwirkstoffe |
CZ20013289A3 (cs) | 1999-03-12 | 2002-01-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Sloučeniny výhodné jako protizánětové prostředky |
DK1165096T3 (da) | 1999-03-29 | 2010-01-25 | Shire Canada Inc | Anvendelse af cytidinderivater til behandling af leukæmi |
WO2000059930A1 (en) | 1999-04-05 | 2000-10-12 | Merck & Co., Inc. | A method of treating cancer |
US6355636B1 (en) | 1999-04-21 | 2002-03-12 | American Cyanamid Company | Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases |
AU776962B2 (en) | 1999-04-21 | 2004-09-30 | Wyeth Holdings Corporation | Substituted 3-cyano-(1.7), (1.5), and (1.8)-naphthyridine inhibitors of tyrosine kinases |
NZ515285A (en) | 1999-05-21 | 2004-01-30 | Scios Inc | Indole-type derivatives as inhibitors of p38 kinase |
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
WO2001004115A2 (en) | 1999-07-09 | 2001-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel process for synthesis of heteroaryl-substituted urea compounds |
AU1899501A (en) | 1999-11-27 | 2001-06-04 | Dong Wha Pharmaceutical Industrial Co., Ltd. | Novel 3-nitropyridine derivatives and the pharmaceutical compositions containingsaid derivatives |
JP2003523952A (ja) | 1999-11-27 | 2003-08-12 | ドン ファ ファーマシューティカル インダストリアル カンパニー リミテッド | 新規な3−ニトロピリジン誘導体及び該誘導体を含む製薬組成物 |
US6608058B2 (en) | 2000-04-17 | 2003-08-19 | Dong Wha Pharm. Ind. Co., Ltd. | 6-methylnicotinamide derivatives as antiviral agents |
WO2002042292A2 (en) | 2000-11-20 | 2002-05-30 | Scios Inc. | Indol derivative and their use as inhibitors of p38 kinase |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
NZ526528A (en) | 2001-03-09 | 2005-02-25 | Pfizer Prod Inc | Triazolopyridines as anti-inflammatory agents |
US7199147B2 (en) | 2001-06-12 | 2007-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Rho kinase inhibitors |
EP1432416B1 (de) | 2001-09-26 | 2011-01-19 | Pfizer Italia S.r.l. | Aminoindazolderivate mit kinaseinhibierender wirkung, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
WO2003032989A1 (en) | 2001-10-18 | 2003-04-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
WO2003051847A1 (en) | 2001-12-19 | 2003-06-26 | Smithkline Beecham P.L.C. | (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors |
CA2473634C (en) | 2002-02-25 | 2011-11-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
FR2836914B1 (fr) | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
AU2003221184A1 (en) | 2002-03-29 | 2003-10-27 | Mochida Pharmaceutical Co., Ltd. | Therapeutic agent for endothelial disorder |
MXPA05000825A (es) | 2002-07-19 | 2005-08-29 | Memory Pharm Corp | Compuestos de 6-amino-1h-indazol y 4-aminobenzofurano como inhibidores de fosfodiesterasa 4. |
AU2003278249B8 (en) | 2002-09-05 | 2010-11-18 | Aventis Pharma S.A. | Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same |
KR20050071598A (ko) | 2002-10-24 | 2005-07-07 | 메르크 파텐트 게엠베하 | 라프-키나아제 억제제로서의 메틸렌 우레아 유도체 |
ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
US7196082B2 (en) | 2002-11-08 | 2007-03-27 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
AU2003293376A1 (en) | 2002-12-10 | 2004-06-30 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
JP4617299B2 (ja) | 2003-03-03 | 2011-01-19 | アレイ バイオファーマ、インコーポレイテッド | p38阻害剤及びその使用法 |
GB0320244D0 (en) | 2003-05-06 | 2003-10-01 | Aventis Pharma Inc | Pyrazoles as inhibitors of tumour necrosis factor |
US7129252B2 (en) | 2003-06-16 | 2006-10-31 | Guoqing P Chen | Six membered amino-amide derivatives an angiogenisis inhibitors |
SE0301906D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | New compounds |
WO2005004818A2 (en) | 2003-07-09 | 2005-01-20 | Imclone Systems Incorporated | Heterocyclic compounds and their use as anticancer agents |
JP4895811B2 (ja) | 2003-09-11 | 2012-03-14 | ケミア,インコーポレイテッド | サイトカイン阻害剤 |
WO2005063715A1 (en) | 2003-12-18 | 2005-07-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Polymorph of birb 796, a p38map kinase inhibitor |
EP1699783B1 (de) | 2003-12-22 | 2012-07-25 | Eli Lilly And Company | Antagonisten des opioidrezeptors |
TW200716561A (en) | 2005-05-11 | 2007-05-01 | Array Biopharma Inc | P38 inhibitors and methods of use thereof |
UA94733C2 (ru) | 2006-01-31 | 2011-06-10 | Эррей Биофарма Инк. | Ингибиторы киназы и способы их использования |
-
2007
- 2007-01-26 UA UAA200810690A patent/UA94733C2/ru unknown
- 2007-01-26 NZ NZ570846A patent/NZ570846A/en unknown
- 2007-01-26 RS RS20120119A patent/RS52298B/en unknown
- 2007-01-26 AT AT07762713T patent/ATE542800T1/de active
- 2007-01-26 ES ES07762713T patent/ES2379656T3/es active Active
- 2007-01-26 DK DK07762713.1T patent/DK1981851T3/da active
- 2007-01-26 RU RU2008135332/04A patent/RU2442777C2/ru active
- 2007-01-26 CN CN2007800120196A patent/CN101415685B/zh active Active
- 2007-01-26 CA CA2635813A patent/CA2635813C/en active Active
- 2007-01-26 KR KR1020087021184A patent/KR101357465B1/ko active IP Right Grant
- 2007-01-26 MY MYPI20082836 patent/MY151835A/en unknown
- 2007-01-26 SI SI200730895T patent/SI1981851T1/sl unknown
- 2007-01-26 WO PCT/US2007/002272 patent/WO2007089646A1/en active Application Filing
- 2007-01-26 PT PT07762713T patent/PT1981851E/pt unknown
- 2007-01-26 JP JP2008553277A patent/JP5131990B2/ja active Active
- 2007-01-26 BR BRPI0707401A patent/BRPI0707401B8/pt active IP Right Grant
- 2007-01-26 PL PL07762713T patent/PL1981851T3/pl unknown
- 2007-01-26 AU AU2007210073A patent/AU2007210073B2/en active Active
- 2007-01-26 SG SG2011073152A patent/SG175599A1/en unknown
- 2007-01-26 EP EP07762713A patent/EP1981851B1/de active Active
- 2007-01-26 US US12/161,412 patent/US8044083B2/en active Active
- 2007-01-30 TW TW096103341A patent/TWI388557B/zh active
-
2008
- 2008-07-22 IL IL192949A patent/IL192949A/en active IP Right Grant
- 2008-07-25 ZA ZA200806507A patent/ZA200806507B/xx unknown
-
2009
- 2009-01-23 HK HK09100807.4A patent/HK1123548A1/xx unknown
-
2011
- 2011-02-03 US US13/020,578 patent/US8039639B2/en active Active
-
2012
- 2012-03-19 CY CY20121100291T patent/CY1112770T1/el unknown
- 2012-03-21 HR HR20120256T patent/HRP20120256T1/hr unknown
- 2012-05-08 IL IL219644A patent/IL219644A/en active IP Right Grant
- 2012-05-08 IL IL219643A patent/IL219643A/en active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE542800T1 (de) | Kinasehemmer und ihre anwendungsverfahren | |
EA201200049A1 (ru) | 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17 | |
EA200970447A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
NO20084418L (no) | Azolopyridin-3-on derivater som inhibitorer av endoteliallipase | |
EA200900821A1 (ru) | Производные 1-аминометил-l-фенилциклогексана как ингибиторы дпп-iv (дипептидилпептидазы-iv) | |
EA201490949A1 (ru) | Ингибиторы киназ | |
PT1940839E (pt) | Inibidores de piridopirimidinona pi3k alfa | |
MX2009011950A (es) | Derivados de pirimidina y composiciones como inhibidores de cinasa c-kit y pdgfr. | |
TNSN08178A1 (en) | Triazolopyridine derivatives as inhibitors of lipases and phospholipases | |
EA201000554A1 (ru) | Ингибиторы протеинкиназ | |
MX2009006535A (es) | Derivados de indol-4-il-pirimidinil-2-il-amina y su uso como inhibidores de cinasa dependiente de ciclina. | |
WO2006123113A3 (en) | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | |
EA201100580A1 (ru) | Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
MY149512A (en) | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | |
MY155719A (en) | 2-benzylpyridazinone derivatives as met kinase inhibitors | |
HK1133012A1 (en) | Pyrimidinones as casein kinase ii (ck2) modulators | |
NO20065762L (no) | Prodroger av pyrrolypyrimidin-ERK-proteinkinaseinhibitorer. | |
MX2009010485A (es) | Derivados de imidazolidinacarboxamida como inhibidores de lipasas y fosfolipasas. | |
MX2011011764A (es) | Compuestos de carboxamida y su uso como inhibidores de calpaina. | |
MX2009011952A (es) | Compuestos y composiciones como inhibidores de cinasa c-kit y pdgfr. | |
MX2009002842A (es) | Inhibidores heterociclicos de c-met y usos de los mismos. | |
UA107675C2 (en) | N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer | |
ATE502935T1 (de) | C-met-proteinkinasehemmer | |
EA200801200A1 (ru) | ПРОИЗВОДНЫЕ ПИРАЗОЛИЗОХИНОЛИНМОЧЕВИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ p38 КИНАЗЫ | |
WO2009015000A8 (en) | Pyrazole urea derivatives used as kinase inhibitors |