CY1123625T1 - Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων - Google Patents

Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων

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Publication number
CY1123625T1
CY1123625T1 CY20201100404T CY201100404T CY1123625T1 CY 1123625 T1 CY1123625 T1 CY 1123625T1 CY 20201100404 T CY20201100404 T CY 20201100404T CY 201100404 T CY201100404 T CY 201100404T CY 1123625 T1 CY1123625 T1 CY 1123625T1
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CY
Cyprus
Prior art keywords
methods
diseases
pain
compositions
treatment
Prior art date
Application number
CY20201100404T
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English (en)
Inventor
Jay Jie-Qiang Wu
Original Assignee
Vm Discovery, Inc.
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Filing date
Publication date
Application filed by Vm Discovery, Inc. filed Critical Vm Discovery, Inc.
Publication of CY1123625T1 publication Critical patent/CY1123625T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
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    • C07D513/04—Ortho-condensed systems

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις οι οποίες ανταγωνίζονται κινάση C πρωτεΐνης έψιλον (ΡΚCε). Αυτές οι ενώσεις έχουν συντακτικό τύπο (Ia), (Ic) ή (II). Η παρούσα εφεύρεση επίσης παρέχει φαρμακευτικές συνθέσεις που περιέχουν αυτές τις ενώσεις και μεθόδους θεραπείας διαφόρων ασθενειών, καταστάσεων ή/και συμπτωμάτων με χρήση αυτών των ενώσεων.
CY20201100404T 2008-10-10 2020-05-04 Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων CY1123625T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10467208P 2008-10-10 2008-10-10
EP09820030.6A EP2356109B1 (en) 2008-10-10 2009-10-12 Compositions and methods for treating alcohol use disorders, pain and other diseases
PCT/US2009/060367 WO2010042925A2 (en) 2008-10-10 2009-10-12 Compositions and methods for treating alcohol use disorders, pain and other diseases

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CY1123625T1 true CY1123625T1 (el) 2022-03-24

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CY20171100243T CY1118665T1 (el) 2008-10-10 2017-02-22 Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων
CY20201100404T CY1123625T1 (el) 2008-10-10 2020-05-04 Συνθεσεις και μεθοδοι για θεραπεια διαταραχων χρησης αλκοολης, πονου και αλλων ασθενειων

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CN102177153A (zh) 2011-09-07
ES2782376T3 (es) 2020-09-14
LT3135672T (lt) 2020-05-25
CN102177153B (zh) 2016-09-21
CY1118665T1 (el) 2017-07-12
DK2356109T3 (en) 2017-03-13
LT2356109T (lt) 2017-03-27
EP2356109A2 (en) 2011-08-17
EP3135672B1 (en) 2020-02-19
EP2356109B1 (en) 2016-12-07
PT2356109T (pt) 2017-03-10
HUE033711T2 (en) 2017-12-28
PL3135672T3 (pl) 2020-11-16
PL2356109T3 (pl) 2017-07-31
US8729081B2 (en) 2014-05-20
WO2010042925A2 (en) 2010-04-15
CN106243100B (zh) 2019-04-09
HRP20200552T1 (hr) 2020-07-10
SI3135672T1 (sl) 2020-07-31
PT3135672T (pt) 2020-04-02
EP2356109A4 (en) 2012-05-30
EP3135672A1 (en) 2017-03-01
US20110301149A1 (en) 2011-12-08
WO2010042925A3 (en) 2010-07-29
DK3135672T3 (da) 2020-05-04
CN106243100A (zh) 2016-12-21
HRP20170357T1 (hr) 2017-05-05
EP3135672B9 (en) 2020-05-20
ES2617873T3 (es) 2017-06-20
HUE050319T2 (hu) 2020-11-30
SI2356109T1 (sl) 2017-04-26

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