HUE050319T2 - Kompozíciók és eljárások alkoholfogyasztással kapcsolatos rendellenességek, fájdalom és más betegségek kezelésére - Google Patents

Kompozíciók és eljárások alkoholfogyasztással kapcsolatos rendellenességek, fájdalom és más betegségek kezelésére

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Publication number
HUE050319T2
HUE050319T2 HUE16187663A HUE16187663A HUE050319T2 HU E050319 T2 HUE050319 T2 HU E050319T2 HU E16187663 A HUE16187663 A HU E16187663A HU E16187663 A HUE16187663 A HU E16187663A HU E050319 T2 HUE050319 T2 HU E050319T2
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HU
Hungary
Prior art keywords
pain
diseases
compositions
methods
alcohol use
Prior art date
Application number
HUE16187663A
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English (en)
Inventor
Jay Jie-Qiang Wu
Original Assignee
Vm Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vm Discovery Inc filed Critical Vm Discovery Inc
Publication of HUE050319T2 publication Critical patent/HUE050319T2/hu

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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HUE16187663A 2008-10-10 2009-10-12 Kompozíciók és eljárások alkoholfogyasztással kapcsolatos rendellenességek, fájdalom és más betegségek kezelésére HUE050319T2 (hu)

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US10467208P 2008-10-10 2008-10-10

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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3135672T (lt) 2008-10-10 2020-05-25 Vm Discovery, Inc. Kompozicijos ir būdai skirti gydyti alkoholio vartojimo sutrikimus, skausmą ir kitas ligas
CA2814503A1 (en) 2010-10-11 2012-04-19 The Board Of Trustees Of The Leland Stanford Junior Unversity Substituted benzamides and their uses
EP2714048A4 (en) * 2011-05-27 2014-11-05 Univ Temple SUBSTITUTED 2-BENZYLIDENE-2H-BENZO [B] [1,4] THIAZIN-3 (4H) -ONES, DERIVED THEREFROM, AND THEIR THERAPEUTIC USES
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
RS59734B1 (sr) 2012-01-23 2020-02-28 Sage Therapeutics Inc Formulacije neuroaktivnog steroida koje uključuju kompleks alopregnanolona i sulfobutil etar beta-ciklodekstrina
EP2838534A4 (en) * 2012-04-12 2015-11-11 Univ Leland Stanford Junior SUBSTITUTED BENZAMIDES AND USES THEREOF
US20140057885A1 (en) * 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
PT2906221T (pt) * 2012-10-11 2019-07-23 Southern Res Inst Derivados de amida e ureia de aminoalquilpiperazinas e sua utilização
US20150313915A1 (en) 2012-11-30 2015-11-05 The Regents Of The University Of California Anticonvulsant activity of steroids
AP2015008721A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CA2936886A1 (en) 2014-02-27 2015-08-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof
AU2015274333A1 (en) * 2014-06-12 2017-01-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Heterocyclic compounds and methods of use thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
RU2766155C2 (ru) 2016-03-08 2022-02-08 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, их композиции и применения
ES2696516B2 (es) * 2017-07-12 2019-06-19 Consejo Superior Investigacion Compuestos derivados de piperidina como inhibidores de PDE8A
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
JP2023524806A (ja) 2020-05-04 2023-06-13 アムジェン インコーポレイテッド ミエロイド細胞に発現するトリガー受容体２アゴニストとしての複素環化合物及び使用方法
TW202208355A (zh) 2020-05-04 2022-03-01 美商安進公司 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
DE2711655A1 (de) 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
JP2002053566A (ja) * 2000-08-11 2002-02-19 Japan Tobacco Inc チアゾール化合物及びその医薬用途
EP1394154A4 (en) * 2001-03-23 2005-05-18 Takeda Pharmaceutical HETEROCYCLIC DERIVATIVE WITH FIVE MEMBERS OF ALKANOIC ACID
ATE292633T1 (de) 2001-07-19 2005-04-15 Cv Therapeutics Inc Substituierte piperazinderivate und ihre verwendung als fettsaüreoxidationsinhibitoren
US7595343B2 (en) * 2001-09-14 2009-09-29 Methylgene, Inc. Inhibitors of histone deacetylase
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
JP4313678B2 (ja) * 2001-12-27 2009-08-12 大日本住友製薬株式会社 ヒドロキサム酸誘導体およびそれを有効成分とするｍｍｐ阻害剤
AU2003262023A1 (en) * 2002-09-10 2004-04-30 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
US20050038078A1 (en) * 2003-08-11 2005-02-17 Agouron Pharmaceuticals, Inc. Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use
JP2007509185A (ja) * 2003-10-27 2007-04-12 ノバルティス アクチエンゲゼルシャフト βアミロイド産生および／または凝集と関係がある神経障害および血管障害の処置のためのインドリル−ピロールジオン誘導体
GB0403635D0 (en) 2004-02-18 2004-03-24 Devgen Nv Pyridinocarboxamides with improved activity as kinase inhibitors
DE602004004631D1 (de) * 2004-04-01 2007-03-22 Sanofi Aventis Deutschland Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika
AU2006228690A1 (en) * 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
KR20080014075A (ko) * 2005-05-25 2008-02-13 닛뽕 케미파 가부시키가이샤 페록시좀 증식제 활성화 수용체의 활성화제
JP2009505948A (ja) * 2005-07-11 2009-02-12 デブジェン エヌブイ キナーゼ阻害剤としてのアミド誘導体
JPWO2007013694A1 (ja) * 2005-07-29 2009-02-12 武田薬品工業株式会社 フェノキシアルカン酸化合物
WO2007084391A2 (en) * 2006-01-18 2007-07-26 Amgen Inc. Thiazole compounds as protein kinase b ( pkb) inhibitors
NZ571271A (en) * 2006-03-23 2011-10-28 Biota Europe Ltd The use of benzamide or pyridinamide derivatives as antibacterial agents
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
WO2008038841A1 (fr) * 2006-09-30 2008-04-03 Japan Tobacco Inc. Dérivé de thiadiazolone et utilisation de celui-ci
WO2008053863A1 (fr) 2006-10-30 2008-05-08 Santen Pharmaceutical Co., Ltd. Nouveau composé ayant un squelette de 1,4-benzothiazin-3-one ou un squelette de 3,4-dihydroquinolin-2-one
JP2008231088A (ja) * 2006-10-30 2008-10-02 Santen Pharmaceut Co Ltd １，４−ベンゾオキサジン−３−オン骨格を有する新規化合物
WO2008117982A1 (en) 2007-03-28 2008-10-02 Crystal Genomics, Inc. Heterocyclic carboxylic acid derivatives and pharmaceutical composition for inhibiting lipid accumulation containing same
EP2190466A4 (en) * 2007-08-10 2011-12-21 Burnham Inst Medical Research Tissue-specific alkaline phosphatase (TNAP) activators and their use
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
LT3135672T (lt) 2008-10-10 2020-05-25 Vm Discovery, Inc. Kompozicijos ir būdai skirti gydyti alkoholio vartojimo sutrikimus, skausmą ir kitas ligas
JP6643807B2 (ja) 2015-03-09 2020-02-12 キヤノン株式会社 文書管理クライアント装置、文書管理方法

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PL2356109T3 (pl) 2017-07-31
HRP20170357T1 (hr) 2017-05-05
CN102177153A (zh) 2011-09-07
EP3135672B1 (en) 2020-02-19
PT3135672T (pt) 2020-04-02
EP2356109A4 (en) 2012-05-30
CN106243100B (zh) 2019-04-09
EP3135672A1 (en) 2017-03-01
DK3135672T3 (da) 2020-05-04
DK2356109T3 (en) 2017-03-13
WO2010042925A3 (en) 2010-07-29
LT3135672T (lt) 2020-05-25
EP2356109B1 (en) 2016-12-07
EP3135672B9 (en) 2020-05-20
CN106243100A (zh) 2016-12-21
EP2356109A2 (en) 2011-08-17
CN102177153B (zh) 2016-09-21
CY1118665T1 (el) 2017-07-12
WO2010042925A2 (en) 2010-04-15
PL3135672T3 (pl) 2020-11-16
SI3135672T1 (sl) 2020-07-31
HRP20200552T1 (hr) 2020-07-10
HUE033711T2 (hu) 2017-12-28
ES2782376T3 (es) 2020-09-14
SI2356109T1 (sl) 2017-04-26
CY1123625T1 (el) 2022-03-24
ES2617873T3 (es) 2017-06-20
PT2356109T (pt) 2017-03-10
LT2356109T (lt) 2017-03-27
US20110301149A1 (en) 2011-12-08

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