ATE296825T1 - 4-aminopyrrole(3,2-d)pyrimidine als neuropeptid rezeptor antagonisten - Google Patents

4-aminopyrrole(3,2-d)pyrimidine als neuropeptid rezeptor antagonisten

Info

Publication number
ATE296825T1
ATE296825T1 AT98929573T AT98929573T ATE296825T1 AT E296825 T1 ATE296825 T1 AT E296825T1 AT 98929573 T AT98929573 T AT 98929573T AT 98929573 T AT98929573 T AT 98929573T AT E296825 T1 ATE296825 T1 AT E296825T1
Authority
AT
Austria
Prior art keywords
aminopyrrole
pyrimidines
receptor antagonists
neuropeptide receptor
neuropeptide
Prior art date
Application number
AT98929573T
Other languages
English (en)
Inventor
Robert Lee Dow
Marlys Hammond
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE296825T1 publication Critical patent/ATE296825T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
AT98929573T 1997-08-05 1998-07-10 4-aminopyrrole(3,2-d)pyrimidine als neuropeptid rezeptor antagonisten ATE296825T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5473497P 1997-08-05 1997-08-05
PCT/IB1998/001053 WO1999007703A1 (en) 1997-08-05 1998-07-10 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
ATE296825T1 true ATE296825T1 (de) 2005-06-15

Family

ID=21993163

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98929573T ATE296825T1 (de) 1997-08-05 1998-07-10 4-aminopyrrole(3,2-d)pyrimidine als neuropeptid rezeptor antagonisten

Country Status (32)

Country Link
US (1) US6187778B1 (de)
EP (1) EP1003744B1 (de)
JP (1) JP3711238B2 (de)
KR (1) KR20010022583A (de)
CN (1) CN1264381A (de)
AP (1) AP9801312A0 (de)
AT (1) ATE296825T1 (de)
AU (1) AU7927498A (de)
BG (1) BG104107A (de)
BR (1) BR9811844A (de)
CA (1) CA2293621C (de)
CO (1) CO4960634A1 (de)
DE (1) DE69830409T2 (de)
EA (1) EA200000098A1 (de)
ES (1) ES2241146T3 (de)
GT (1) GT199800114A (de)
HR (1) HRP980434A2 (de)
HU (1) HUP0002956A3 (de)
ID (1) ID24300A (de)
IL (1) IL133430A0 (de)
IS (1) IS5294A (de)
MA (1) MA24629A1 (de)
NO (1) NO996178L (de)
OA (1) OA11277A (de)
PA (1) PA8456601A1 (de)
PE (1) PE106199A1 (de)
PL (1) PL338575A1 (de)
SA (1) SA98190435A (de)
TN (1) TNSN98148A1 (de)
TR (1) TR200000333T2 (de)
WO (1) WO1999007703A1 (de)
ZA (1) ZA986968B (de)

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HUP0203895A3 (en) * 1999-12-24 2004-09-28 Aventis Pharma Ltd West Mallin Substituted azaindoles and pharmaceutical compositions containing them and their use
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
RU2389731C2 (ru) 2004-06-02 2010-05-20 Такеда Фармасьютикал Компани Лимитед Конденсированное гетероциклическое соединение
NZ552093A (en) 2004-06-17 2009-06-26 Wyeth Corp Processes for preparing gonadotropin releasing hormone receptor antagonists
US7696210B2 (en) 2004-06-17 2010-04-13 Wyeth Gonadotropin releasing hormone receptor antagonists
TW200615268A (en) * 2004-08-02 2006-05-16 Osi Pharm Inc Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
WO2006080821A1 (en) * 2005-01-28 2006-08-03 Daewoong Pharmaceutical Co., Ltd. Novel benzoimidazole derivatives and pharmaceutical composition comprising the same
KR20060087386A (ko) * 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
WO2006108218A1 (en) * 2005-04-15 2006-10-19 Regenertech Pty Limited Use of neuropeptide y (npy) and agonists and antagonists thereof for tissue regeneration
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
EP1905769B1 (de) * 2005-07-13 2017-03-29 Msd K.K. Heterocyclisch substituiertes benzimidazolderivat
AR057525A1 (es) * 2005-10-03 2007-12-05 Astrazeneca Ab Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
UY29825A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones
JP2009531274A (ja) * 2005-12-07 2009-09-03 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド キナーゼ阻害性ピロロピリジン化合物
ES2526813T3 (es) * 2005-12-22 2015-01-15 Cancer Research Technology Limited Inhibidores de enzimas
ES2374455T3 (es) 2006-02-17 2012-02-16 Pfizer Limited Derivados de 3-deazapurinza como moduladores de tlr7.
US8796293B2 (en) 2006-04-25 2014-08-05 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
KR101134239B1 (ko) 2006-07-11 2012-04-10 주식회사 대웅제약 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물
PL2054405T3 (pl) * 2006-07-11 2014-03-31 Dae Woong Pharma Nowe pochodne biarylobenzimidazolu i zawierająca je kompozycja farmaceutyczna
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
WO2008121064A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
NZ585261A (en) 2007-10-11 2011-10-28 Astrazeneca Ab Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors
CN101965350A (zh) 2008-01-11 2011-02-02 纳科法尔马有限公司 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物
BR112013025410A2 (pt) 2011-04-01 2016-12-20 Astrazeneca Ab tratamento terapêutico
HUE046667T2 (hu) 2011-11-30 2020-03-30 Astrazeneca Ab Rák kombinatív kezelése
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms

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DE2818676A1 (de) * 1978-04-27 1979-11-08 Troponwerke Gmbh & Co Kg Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5284971A (en) 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
ATE159515T1 (de) 1992-07-21 1997-11-15 Ciba Geigy Ag Oxamidsäure-derivate als hypocholesterämische mittel
ES2109796T3 (es) * 1994-05-03 1998-01-16 Ciba Geigy Ag Derivados de pirrolopirimidilo con efecto antiproliferante.
JP4145955B2 (ja) * 1994-09-29 2008-09-03 ノバルティス アクチェンゲゼルシャフト ピロロ〔２，３−ｄ〕ピリミジン及びその使用
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
SK57097A3 (en) 1994-11-07 1998-10-07 Pfizer Certain substituted benzylamine derivatives; a new class of neuropeptide y1 specific ligands
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
EP0759441A3 (de) 1995-06-30 1999-06-30 Eli Lilly And Company Verfahren zur Behandlung von mit Neuropeptid Y assozierten Zuständen
AU2242197A (en) 1996-01-09 1997-08-01 Eli Lilly And Company Benzimidzolyl neuropeptide y receptor antagonists

Also Published As

Publication number Publication date
OA11277A (en) 2003-07-29
EA200000098A1 (ru) 2000-08-28
JP2001512729A (ja) 2001-08-28
ZA986968B (en) 2000-02-04
IL133430A0 (en) 2001-04-30
CA2293621C (en) 2003-12-30
TR200000333T2 (tr) 2000-05-22
JP3711238B2 (ja) 2005-11-02
DE69830409D1 (de) 2005-07-07
BG104107A (bg) 2000-08-31
BR9811844A (pt) 2000-08-08
MA24629A1 (fr) 1999-04-01
KR20010022583A (ko) 2001-03-26
NO996178L (no) 2000-02-14
TNSN98148A1 (fr) 2005-03-15
EP1003744A1 (de) 2000-05-31
PE106199A1 (es) 1999-11-02
DE69830409T2 (de) 2006-01-26
NO996178D0 (no) 1999-12-14
GT199800114A (es) 2000-01-18
CA2293621A1 (en) 1999-02-18
SA98190435A (ar) 2005-12-03
IS5294A (is) 1999-12-10
CN1264381A (zh) 2000-08-23
CO4960634A1 (es) 2000-09-25
AP9801312A0 (en) 2000-01-30
HUP0002956A2 (hu) 2001-08-28
PL338575A1 (en) 2000-11-06
ID24300A (id) 2000-07-13
PA8456601A1 (es) 2000-05-24
EP1003744B1 (de) 2005-06-01
HRP980434A2 (en) 1999-04-30
HUP0002956A3 (en) 2002-01-28
ES2241146T3 (es) 2005-10-16
WO1999007703A1 (en) 1999-02-18
AU7927498A (en) 1999-03-01
US6187778B1 (en) 2001-02-13

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