PE106199A1 - 4-aminopirrol (3,2-d) pirimidinas como antagonistas del receptor del neuropeptido y - Google Patents

4-aminopirrol (3,2-d) pirimidinas como antagonistas del receptor del neuropeptido y

Info

Publication number
PE106199A1
PE106199A1 PE1998000678A PE00067898A PE106199A1 PE 106199 A1 PE106199 A1 PE 106199A1 PE 1998000678 A PE1998000678 A PE 1998000678A PE 00067898 A PE00067898 A PE 00067898A PE 106199 A1 PE106199 A1 PE 106199A1
Authority
PE
Peru
Prior art keywords
alkyl
compound
group
disorders
aryl
Prior art date
Application number
PE1998000678A
Other languages
English (en)
Inventor
Robert Lee Dow
Marlys Hammond
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE106199A1 publication Critical patent/PE106199A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO I, DONDE B, D Y E SON CR1, CR9 o N, UNO DE B, D o E ES CR1 Y AL MENOS UNO ES N; F Y G SON N, NR4, CR5; F o G ES N o NR4; CUANDO B Y E SON AMBOS N; F o G ES CR5; R1, R3, R4, R5 Y R9 SON H, ALQUILO C1-C6, ALCOXI C1-C6, (CH2)n-Ar ENTRE OTROS; R2 ES NR6R7, GRUPO a, NH(CH2)nPh, ENTRE OTROS; CUANDO R2 ES GRUPO a, UNO DE m Y n ES CERO Y EL OTRO ES 2; G ES S, O, NR8 o UN ENLACE; R8 ES H, ALQUILO C1-C6 o ARILO, (ALQUILO C1-C6)-CO-, o ARILO-CO-, R6 Y R7 SON H, ALQUILO C1-C6, (CH2)kOH; n ES 0-6; m ES 0-2; k ES 0-4; Ar ES GRUPO AROMATICO DE 3-7 MIEMBROS o UN HETEROCICLO BICICLICO; SI F ES NR4, G ES CR5, B Y E SON N, D ES CR1, R1 ES METILO; R3 ES FENILO; R4 Y R5 SON H, ENTONCES R2 NO SERA NET2, HN(CH2)2NET2, HN(CH3)2COOH, ENTRE OTROS. UN COMPUESTO PREFERIDO ES 2-METIL-4-ISOPROPILAMINO-6-FENILPIRROLO[3,2-d]PIRIMIDINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS UN �3-ADRENERGICO O UN AGENTE TIROMIMETICO. EL COMPUESTO I ES UN INHIBIDOR DEL NEUROPEPTIDO Y, POR LO QUE PUEDE SER UTIL PARA TRATAR TRASTORNOS DE LA ALIMENTACION COMO OBESIDAD O BULIMIA, TRASTORNOS O ENFERMEDAES DEL CORAZON, TRASTORNOS RELACIONADOS CON UNA MAYOR ACTIVIDAD DEL NERVIO SIMPATICO, ENFERMEDADES RELACIONADAS CON EL SISTEMA NERVIOSO CENTRAL, ENFERMEDADES RELACIONADAS CON EL DOLOR O LA NOCICEPCION
PE1998000678A 1997-08-05 1998-07-30 4-aminopirrol (3,2-d) pirimidinas como antagonistas del receptor del neuropeptido y PE106199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5473497P 1997-08-05 1997-08-05

Publications (1)

Publication Number Publication Date
PE106199A1 true PE106199A1 (es) 1999-11-02

Family

ID=21993163

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000678A PE106199A1 (es) 1997-08-05 1998-07-30 4-aminopirrol (3,2-d) pirimidinas como antagonistas del receptor del neuropeptido y

Country Status (32)

Country Link
US (1) US6187778B1 (es)
EP (1) EP1003744B1 (es)
JP (1) JP3711238B2 (es)
KR (1) KR20010022583A (es)
CN (1) CN1264381A (es)
AP (1) AP9801312A0 (es)
AT (1) ATE296825T1 (es)
AU (1) AU7927498A (es)
BG (1) BG104107A (es)
BR (1) BR9811844A (es)
CA (1) CA2293621C (es)
CO (1) CO4960634A1 (es)
DE (1) DE69830409T2 (es)
EA (1) EA200000098A1 (es)
ES (1) ES2241146T3 (es)
GT (1) GT199800114A (es)
HR (1) HRP980434A2 (es)
HU (1) HUP0002956A3 (es)
ID (1) ID24300A (es)
IL (1) IL133430A0 (es)
IS (1) IS5294A (es)
MA (1) MA24629A1 (es)
NO (1) NO996178L (es)
OA (1) OA11277A (es)
PA (1) PA8456601A1 (es)
PE (1) PE106199A1 (es)
PL (1) PL338575A1 (es)
SA (1) SA98190435A (es)
TN (1) TNSN98148A1 (es)
TR (1) TR200000333T2 (es)
WO (1) WO1999007703A1 (es)
ZA (1) ZA986968B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
CN1377355A (zh) * 1999-09-30 2002-10-30 纽罗杰有限公司 氨基取代的吡唑并[1,5－a]－1,5－嘧啶和吡唑并[1,5－a]－1,3,5－三嗪
OA12514A (en) * 1999-12-24 2006-05-29 Aventis Pharma Ltd Azaindoles.
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
MXPA06013996A (es) 2004-06-02 2007-02-08 Takeda Pharmaceutical Compuesto heterociclico fusionado.
NZ552093A (en) 2004-06-17 2009-06-26 Wyeth Corp Processes for preparing gonadotropin releasing hormone receptor antagonists
WO2006009734A1 (en) 2004-06-17 2006-01-26 Wyeth Gonadotropin releasing hormone receptor antagonists
US7465726B2 (en) * 2004-08-02 2008-12-16 Osi Pharmaceuticals, Inc. Substituted pyrrolo[2.3-B]pyridines
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
AU2006209117B2 (en) * 2005-01-28 2009-12-10 Daewoong Pharmaceutical Co., Ltd. Novel benzoimidazole derivatives and pharmaceutical composition comprising the same
KR20060087386A (ko) 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
AU2006235200A1 (en) * 2005-04-15 2006-10-19 Regenertech Pty Limited Use of Neuropeptide Y (NPY) and agonists and antagonists thereof for tissue regeneration
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
JP5281287B2 (ja) * 2005-07-13 2013-09-04 Ｍｓｄ株式会社 ヘテロ環置換ベンズイミダゾール誘導体
UY29823A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
EP1963320A1 (en) * 2005-12-07 2008-09-03 OSI Pharmaceuticals, Inc. Pyrrolopyridine kinase inhibiting compounds
ES2526813T3 (es) * 2005-12-22 2015-01-15 Cancer Research Technology Limited Inhibidores de enzimas
MX2008010611A (es) 2006-02-17 2008-11-12 Pfizer Ltd Derivados de 3-desazapurina como moduladores de receptores similares a toll.
WO2007125321A2 (en) 2006-04-25 2007-11-08 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
CA2656810C (en) * 2006-07-11 2012-03-13 Daewoong Pharmaceutical Co., Ltd. Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
KR101134239B1 (ko) 2006-07-11 2012-04-10 주식회사 대웅제약 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
WO2008121064A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
RS53552B1 (en) 2007-10-11 2015-02-27 Astrazeneca Ab DERIVATI PIROLO [2,3-D] PIRIMIDINA KAO INHIBITORI PROTEIN KINAZE B
CN101965350A (zh) 2008-01-11 2011-02-02 纳科法尔马有限公司 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物
AU2012235902B2 (en) 2011-04-01 2015-08-27 Astrazeneca Ab Therapeutic treatment
JP6309454B2 (ja) 2011-11-30 2018-04-11 アストラゼネカ アクチボラグ 癌の併用処置
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
US11053241B2 (en) * 2018-11-30 2021-07-06 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274213A (en) 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
DE2818676A1 (de) * 1978-04-27 1979-11-08 Troponwerke Gmbh & Co Kg Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9022644D0 (en) * 1990-10-18 1990-11-28 Ici Plc Heterocyclic compounds
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5284971A (en) 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
ATE159515T1 (de) 1992-07-21 1997-11-15 Ciba Geigy Ag Oxamidsäure-derivate als hypocholesterämische mittel
DE59500788D1 (de) * 1994-05-03 1997-11-20 Ciba Geigy Ag Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
CN1046731C (zh) * 1994-09-29 1999-11-24 诺瓦蒂斯有限公司 吡咯并[2,3-d]嘧啶类化合物及其应用
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
PL321136A1 (en) 1994-11-07 1997-11-24 Pfizer Some substituted derivatives of bencylamine as a new class of specific ligands of neuropeptide y1
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
EP0759441A3 (en) 1995-06-30 1999-06-30 Eli Lilly And Company Methods of treating neuropeptide Y-associated conditions
AU2242197A (en) 1996-01-09 1997-08-01 Eli Lilly And Company Benzimidzolyl neuropeptide y receptor antagonists

Also Published As

Publication number Publication date
AP9801312A0 (en) 2000-01-30
EP1003744A1 (en) 2000-05-31
CA2293621A1 (en) 1999-02-18
OA11277A (en) 2003-07-29
HUP0002956A3 (en) 2002-01-28
DE69830409T2 (de) 2006-01-26
ID24300A (id) 2000-07-13
NO996178D0 (no) 1999-12-14
CN1264381A (zh) 2000-08-23
ATE296825T1 (de) 2005-06-15
CO4960634A1 (es) 2000-09-25
CA2293621C (en) 2003-12-30
IL133430A0 (en) 2001-04-30
HRP980434A2 (en) 1999-04-30
US6187778B1 (en) 2001-02-13
GT199800114A (es) 2000-01-18
NO996178L (no) 2000-02-14
EP1003744B1 (en) 2005-06-01
AU7927498A (en) 1999-03-01
ZA986968B (en) 2000-02-04
EA200000098A1 (ru) 2000-08-28
BR9811844A (pt) 2000-08-08
MA24629A1 (fr) 1999-04-01
JP2001512729A (ja) 2001-08-28
KR20010022583A (ko) 2001-03-26
PA8456601A1 (es) 2000-05-24
TR200000333T2 (tr) 2000-05-22
IS5294A (is) 1999-12-10
DE69830409D1 (de) 2005-07-07
HUP0002956A2 (hu) 2001-08-28
SA98190435A (ar) 2005-12-03
TNSN98148A1 (fr) 2005-03-15
BG104107A (bg) 2000-08-31
PL338575A1 (en) 2000-11-06
JP3711238B2 (ja) 2005-11-02
ES2241146T3 (es) 2005-10-16
WO1999007703A1 (en) 1999-02-18

Similar Documents

Publication Publication Date Title
PE106199A1 (es) 4-aminopirrol (3,2-d) pirimidinas como antagonistas del receptor del neuropeptido y
PE20010613A1 (es) Antagonistas de la hormona concentradora de la melanina
PE106499A1 (es) Antagonistas del receptor ccr-3
DK0641328T3 (da) Broforbundne, azabicykliske derivater som substans P-antagonister
ATE166650T1 (de) Spiroazacyclischderivate als substanz p antagonisten
ES2184772T3 (es) Derivados de bifenilo, procedimiento para su preparacion y su utilizacion como medicamentos.
PE108898A1 (es) Derivados 6,5-heterobiciclicos sustituidos
ES2059327T3 (es) Derivados de tetrahidronaftaleno y de indano, obtencion de los mismos y utilizacion en preparados farmaceuticos.
DE59204623D1 (de) Lagerstabile, permanent wasserbenetzbare vulkanisate ergebende polysiloxanmasse.
ATE203515T1 (de) Meta-substituierte phenylsulphonamidderivate
DK0736039T3 (da) Forbindelser med væksthormon-frigivende egenskaber
DK0607164T3 (da) Kondenserede tricykliske nitrogenholdige heterocykliske forbindelser som substans P-receptorantagonister
AR246275A1 (es) Composiciones de catalizador, procedimiento para la preparacion de polimeros de monoxido de carbono, y eteno y nuevo compuesto.
DK0626974T3 (da) Mitogenfrit stof, fremstilling samt anvendelse af dette
PE52799A1 (es) Cicloalquilo, lactama, lactona y compuestos relacionados, composiciones farmaceuticas que comprenden los mismos, como inhibidores de la liberacion de peptido �-amiloide y no cicloalquilo, lactama, lactona y compuestos relacionados, como inhibidores de la liberacion del peptido �-amiloide
PE20000864A1 (es) Benzocicloheptenos, un procedimiento para su preparacion y las composiciones farmaceuticas que los contienen
PT89346A (pt) Processo para a preparacao de novas lactamas triciclicas contendo grupos sulfridilo e de composicoes farmaceuticas que as contem
ES2059335T3 (es) Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento.
PE74899A1 (es) Derivados de ergolina
HUP0003624A2 (hu) 1,2,3,4-Tetrahidro-benzofuro[3,2-c]piridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
NO842482L (no) Fremgangsmaate til fremstilling av beta-karbolinderivater
IT1264765B1 (it) Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
ECSP941050A (es) Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene
DE69011054D1 (de) Substituierte cyclohexene mit zentraler Nervensystem-Wirkung.
UA41350C2 (uk) Похідна морфоліну або її фармацевтично прийнятна сіль та фармацевтична композиція на її основі

Legal Events

Date Code Title Description
FD Application declared void or lapsed