IT1264765B1 - Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la - Google Patents

Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la

Info

Publication number
IT1264765B1
IT1264765B1 IT93TO000167A ITTO930167A IT1264765B1 IT 1264765 B1 IT1264765 B1 IT 1264765B1 IT 93TO000167 A IT93TO000167 A IT 93TO000167A IT TO930167 A ITTO930167 A IT TO930167A IT 1264765 B1 IT1264765 B1 IT 1264765B1
Authority
IT
Italy
Prior art keywords
group
pct
dicyclic
derivatives
procedure
Prior art date
Application number
IT93TO000167A
Other languages
English (en)
Inventor
Francesco Makovec
Walter Peris
Lucio Rovati
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ITTO930167A0 publication Critical patent/ITTO930167A0/it
Priority to IT93TO000167A priority Critical patent/IT1264765B1/it
Priority to EP94909905A priority patent/EP0688312B1/en
Priority to CA002156432A priority patent/CA2156432C/en
Priority to AU62573/94A priority patent/AU685438B2/en
Priority to JP51955394A priority patent/JP3957742B2/ja
Priority to US08/513,964 priority patent/US5723494A/en
Priority to AT94909905T priority patent/ATE173461T1/de
Priority to DE69414695T priority patent/DE69414695T2/de
Priority to PCT/EP1994/000604 priority patent/WO1994020454A1/en
Priority to ES94909905T priority patent/ES2128554T3/es
Publication of ITTO930167A1 publication Critical patent/ITTO930167A1/it
Application granted granted Critical
Publication of IT1264765B1 publication Critical patent/IT1264765B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
IT93TO000167A 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la IT1264765B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT93TO000167A IT1264765B1 (it) 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
JP51955394A JP3957742B2 (ja) 1993-03-10 1994-03-02 グルタミン酸およびアスパラギン酸の新規誘導体、その製造方法およびその記憶力および学習力の増強用医薬品としての用途
CA002156432A CA2156432C (en) 1993-03-10 1994-03-02 New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
AU62573/94A AU685438B2 (en) 1993-03-10 1994-03-02 New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
EP94909905A EP0688312B1 (en) 1993-03-10 1994-03-02 New derivatives of glutamic acid, a method of preparing them, and their use as drugs for enhancing memory and learning
US08/513,964 US5723494A (en) 1993-03-10 1994-03-02 Derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
AT94909905T ATE173461T1 (de) 1993-03-10 1994-03-02 Glutaminsäure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung zur steigerung des erinnerungsvermögens und der lernfähigkeit
DE69414695T DE69414695T2 (de) 1993-03-10 1994-03-02 Glutaminsäure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung zur steigerung des erinnerungsvermögens und der lernfähigkeit
PCT/EP1994/000604 WO1994020454A1 (en) 1993-03-10 1994-03-02 New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
ES94909905T ES2128554T3 (es) 1993-03-10 1994-03-02 Nuevos derivados del acido glutamico, procedimiento para su preparacion y su utilizacion como medicamentos para el aumento de la memoria y aprendizaje.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93TO000167A IT1264765B1 (it) 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la

Publications (3)

Publication Number Publication Date
ITTO930167A0 ITTO930167A0 (it) 1993-03-10
ITTO930167A1 ITTO930167A1 (it) 1994-09-10
IT1264765B1 true IT1264765B1 (it) 1996-10-04

Family

ID=11411249

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93TO000167A IT1264765B1 (it) 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la

Country Status (10)

Country Link
US (1) US5723494A (it)
EP (1) EP0688312B1 (it)
JP (1) JP3957742B2 (it)
AT (1) ATE173461T1 (it)
AU (1) AU685438B2 (it)
CA (1) CA2156432C (it)
DE (1) DE69414695T2 (it)
ES (1) ES2128554T3 (it)
IT (1) IT1264765B1 (it)
WO (1) WO1994020454A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276462B1 (it) * 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
US6218383B1 (en) * 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US20100222316A1 (en) * 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
ITTO20040343A1 (it) * 2004-05-24 2004-08-24 Rotta Res Lab Spa Uso di neboglamine (cr2249) come neuropsicotico e neuroprotettivo
JP4564375B2 (ja) * 2004-08-18 2010-10-20 太陽化学株式会社 テアニンの製造方法
US20060183803A1 (en) * 2005-02-17 2006-08-17 Instituto Del Metabolismo Celular, S.L. L-aspartic acid for the treatment of assorted health problems
ITTO20050691A1 (it) 2005-10-04 2007-04-05 Rottapharm Spa Uso di neboglamine nella terapia delle tossicodipendenze
EP1903028A1 (en) * 2006-09-22 2008-03-26 Werner Tschollar Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects
KR102239629B1 (ko) * 2019-05-24 2021-04-12 이지원 실크 펩타이드의 제조방법 및 이를 이용하여 제조된 기억력 및 인지능력 개선용 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1228271A (it) * 1968-02-09 1971-04-15
US4053609A (en) * 1975-09-12 1977-10-11 Tanabe Seiyaku Co., Ltd. Penicillins and processes for preparing the same
JPS56131554A (en) * 1980-03-17 1981-10-15 Kaken Pharmaceut Co Ltd Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component
JPH06504031A (ja) * 1988-09-30 1994-05-12 オーストレイリアン・コマーシヤル・リサーチ・アンド・デイベロツプメント・リミテツド アミノ酸輸送蛋白質、アミノ酸アナログ、アッセイ装置並びにその癌の治療及び診断への使用
WO1991012232A1 (en) * 1990-02-06 1991-08-22 Australian Commercial Research & Development Limited Compounds and methods for the treatment and diagnosis of cancer
JPH03294253A (ja) * 1990-04-12 1991-12-25 Shionogi & Co Ltd 消化管ホルモン拮抗物質
AU8844891A (en) * 1990-10-22 1992-05-20 Universidad De Granada Hydrolisis method and utilization of aminoacil-2-naphtylamide as diagnosis reagent
IT1241029B (it) * 1990-12-11 1993-12-27 Rotta Research Lab Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione

Also Published As

Publication number Publication date
ES2128554T3 (es) 1999-05-16
DE69414695T2 (de) 1999-06-10
CA2156432A1 (en) 1994-09-15
EP0688312A1 (en) 1995-12-27
EP0688312B1 (en) 1998-11-18
ITTO930167A1 (it) 1994-09-10
US5723494A (en) 1998-03-03
ITTO930167A0 (it) 1993-03-10
AU6257394A (en) 1994-09-26
ATE173461T1 (de) 1998-12-15
JPH08507502A (ja) 1996-08-13
CA2156432C (en) 2006-11-14
WO1994020454A1 (en) 1994-09-15
JP3957742B2 (ja) 2007-08-15
AU685438B2 (en) 1998-01-22
DE69414695D1 (de) 1998-12-24

Similar Documents

Publication Publication Date Title
DK0687268T3 (da) Spiroazacykliske derivater som substans P-antagonister
ITTO920325A1 (it) Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico
CA2269807A1 (en) Substituted aminoalkanephosphonic acids
DE69412250T2 (de) Pyridobismidazole enthaltendes rigid-rod-Polymer
ITMI921601A1 (it) Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.
EA200400432A1 (ru) Производные мочевины
DE59009351D1 (de) Neue arylpyridazine, ihre herstellung, verwendung und sie enthaltende arzneimittel.
ES2150489T3 (es) 1-amidinofenil-pirrolidonas, -piperidinonas, -azetinonas como inhibidores de la agregacion de plaquetas.
DE69705829T2 (de) Meta-substituierte phenylsulphonamidderivate
MX9305379A (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene.
IT1264765B1 (it) Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
DE69313051D1 (de) Ethanolamin-derivate mit sympathomimetischer und anti-pollakiuria wirkung
MD1560F2 (en) Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
DK0701449T3 (da) Fremgangsmåde til fremstilling af en oral fast dosisform indeholdende diclofenac
MX9400165A (es) Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen.
MY110004A (en) Biologically active ureido derivatives useful as antimetastatic agents.
DE68906572D1 (de) Peptide mit inhibitorischer wirkung auf enzymatische systeme, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE69412103T2 (de) Polyamidsäure-derivate mit antigastrin wirkung, ihre herstellung und ihre verwendung als arzneimittel
FI950209A (fi) Farmakologisesti aktiiviset alfa-(tertiaarinen-amino-metyyli)-bentseenimetanolijohdannaiset
ATE186214T1 (de) Verwendung von rosmanolderivaten zur herstellung von antiradikalischen und/oder antilipoperoxidativen und/oder hepatotropen arzneistoffen
MX9303607A (es) Derivados de azabicicloheptano sustituidos, su obtencion y uso.
BR0109252A (pt) Composto, processo para produzir um composto, composição farmacêutica, e, uso de um composto ou de uma composição

Legal Events

Date Code Title Description
0001 Granted