ITMI921601A1 - Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. - Google Patents
Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.Info
- Publication number
- ITMI921601A1 ITMI921601A1 IT001601A ITMI921601A ITMI921601A1 IT MI921601 A1 ITMI921601 A1 IT MI921601A1 IT 001601 A IT001601 A IT 001601A IT MI921601 A ITMI921601 A IT MI921601A IT MI921601 A1 ITMI921601 A1 IT MI921601A1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- pct
- homo
- bile acids
- absorption promoters
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921601A IT1255449B (it) | 1992-06-30 | 1992-06-30 | Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. |
DE69316217T DE69316217T2 (de) | 1992-06-30 | 1993-06-15 | Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel |
AT93912975T ATE161731T1 (de) | 1992-06-30 | 1993-06-15 | Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel |
US08/360,833 US5656277A (en) | 1992-06-30 | 1993-06-15 | Nor- and homo- bile acids derivatives as absorption enhancers for medicaments |
ES93912975T ES2114056T3 (es) | 1992-06-30 | 1993-06-15 | Uso de derivados nor y homo de acidos biliares como potenciadores de absorcion para medicamentos. |
EP93912975A EP0652773B1 (en) | 1992-06-30 | 1993-06-15 | The use of nor- and homo- bile acids derivatives as absorption enhancers for medicaments |
PCT/EP1993/001508 WO1994000155A1 (en) | 1992-06-30 | 1993-06-15 | The use of nor- and homo- bile acids derivatives as absorption enhancers for medicaments |
JP6501998A JPH07508013A (ja) | 1992-06-30 | 1993-06-15 | 医薬物用吸収促進剤としてのノルおよびホモ胆汁酸誘導体の使用 |
DK93912975T DK0652773T3 (da) | 1992-06-30 | 1993-06-15 | Anvendelse af nor- og homo-galdesyrederivater somabsorptionsfremmende bestanddele i lægemidler |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921601A IT1255449B (it) | 1992-06-30 | 1992-06-30 | Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI921601A0 ITMI921601A0 (it) | 1992-06-30 |
ITMI921601A1 true ITMI921601A1 (it) | 1993-12-30 |
IT1255449B IT1255449B (it) | 1995-10-31 |
Family
ID=11363597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI921601A IT1255449B (it) | 1992-06-30 | 1992-06-30 | Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5656277A (it) |
EP (1) | EP0652773B1 (it) |
JP (1) | JPH07508013A (it) |
AT (1) | ATE161731T1 (it) |
DE (1) | DE69316217T2 (it) |
DK (1) | DK0652773T3 (it) |
ES (1) | ES2114056T3 (it) |
IT (1) | IT1255449B (it) |
WO (1) | WO1994000155A1 (it) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0821970A1 (en) * | 1996-08-02 | 1998-02-04 | Edward Henri Charles Verhaeren | Carrier composition for influencing the tight junction permeability |
CA2294988C (en) | 1997-07-01 | 2015-11-24 | Isis Pharmaceuticals Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
WO2000019978A2 (en) * | 1998-10-05 | 2000-04-13 | The Penn State Research Foundation | Compositions and methods for enhancing receptor-mediated cellular internalization |
US6451286B1 (en) | 1998-12-21 | 2002-09-17 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds |
US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
US6849263B2 (en) * | 1998-12-21 | 2005-02-01 | Generex Pharmaceutical Incorporated | Pharmaceutical compositions for buccal delivery of pain relief medications |
US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US20030118547A1 (en) * | 2000-01-27 | 2003-06-26 | Vandenberg Grant William | Composition for intestinal delivery |
JP4452970B2 (ja) * | 2002-03-27 | 2010-04-21 | 日本臓器製薬株式会社 | ジクロフェナクナトリウム経口製剤 |
AU2005323437B2 (en) | 2004-04-30 | 2011-10-06 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a C5-modified pyrimidine |
HUE030010T2 (en) | 2005-05-12 | 2017-04-28 | Medizinische Universität Graz | 24-norUDCA for the treatment of autoimmune hepatitis |
US20100311708A1 (en) * | 2007-07-25 | 2010-12-09 | Tarek Moustafa | Use of nor-bile acids in the treatment of arteriosclerosis |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
SG11201703717SA (en) | 2014-11-06 | 2017-06-29 | Enanta Pharm Inc | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
AU2015353473A1 (en) | 2014-11-26 | 2017-06-08 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
WO2016086115A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
SG11201706089RA (en) | 2015-02-11 | 2017-09-28 | Enanta Pharm Inc | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
MY192135A (en) | 2015-03-31 | 2022-07-29 | Enanta Pharm Inc | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
WO2017147174A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
WO2017147159A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Deuterated bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
EP3544614A4 (en) | 2016-11-28 | 2020-08-05 | Lipocine Inc. | ORAL TESTOSTERONE UNDECANOATE THERAPY |
ES2918698T3 (es) | 2016-11-29 | 2022-07-19 | Enanta Pharm Inc | Proceso para la preparación de derivados del ácido biliar de las sulfonilureas |
WO2018152171A1 (en) | 2017-02-14 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr agonists and methods of use thereof |
US10676500B2 (en) | 2017-04-07 | 2020-06-09 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
GB201911821D0 (en) | 2019-08-16 | 2019-10-02 | Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid | Compounds for use in the treatment of liver disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4746508A (en) * | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
IT1212835B (it) * | 1983-08-18 | 1989-11-30 | Lehner Ag | Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
-
1992
- 1992-06-30 IT ITMI921601A patent/IT1255449B/it active IP Right Grant
-
1993
- 1993-06-15 AT AT93912975T patent/ATE161731T1/de not_active IP Right Cessation
- 1993-06-15 WO PCT/EP1993/001508 patent/WO1994000155A1/en active IP Right Grant
- 1993-06-15 DE DE69316217T patent/DE69316217T2/de not_active Expired - Fee Related
- 1993-06-15 US US08/360,833 patent/US5656277A/en not_active Expired - Fee Related
- 1993-06-15 ES ES93912975T patent/ES2114056T3/es not_active Expired - Lifetime
- 1993-06-15 JP JP6501998A patent/JPH07508013A/ja active Pending
- 1993-06-15 EP EP93912975A patent/EP0652773B1/en not_active Expired - Lifetime
- 1993-06-15 DK DK93912975T patent/DK0652773T3/da active
Also Published As
Publication number | Publication date |
---|---|
EP0652773B1 (en) | 1998-01-07 |
JPH07508013A (ja) | 1995-09-07 |
DE69316217T2 (de) | 1998-08-20 |
WO1994000155A1 (en) | 1994-01-06 |
ES2114056T3 (es) | 1998-05-16 |
DE69316217D1 (de) | 1998-02-12 |
EP0652773A1 (en) | 1995-05-17 |
IT1255449B (it) | 1995-10-31 |
DK0652773T3 (da) | 1998-09-07 |
ITMI921601A0 (it) | 1992-06-30 |
US5656277A (en) | 1997-08-12 |
ATE161731T1 (de) | 1998-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960627 |