ITTO930167A0 - Nuovi derivati dell'acido glutammico ed acido asparico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la memo ria e l'apprendimento. - Google Patents
Nuovi derivati dell'acido glutammico ed acido asparico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la memo ria e l'apprendimento.Info
- Publication number
- ITTO930167A0 ITTO930167A0 ITTO930167A ITTO930167A ITTO930167A0 IT TO930167 A0 ITTO930167 A0 IT TO930167A0 IT TO930167 A ITTO930167 A IT TO930167A IT TO930167 A ITTO930167 A IT TO930167A IT TO930167 A0 ITTO930167 A0 IT TO930167A0
- Authority
- IT
- Italy
- Prior art keywords
- acid
- learning
- drugs
- procedure
- preparation
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93TO000167A IT1264765B1 (it) | 1993-03-10 | 1993-03-10 | Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la |
CA002156432A CA2156432C (en) | 1993-03-10 | 1994-03-02 | New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning |
US08/513,964 US5723494A (en) | 1993-03-10 | 1994-03-02 | Derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning |
AU62573/94A AU685438B2 (en) | 1993-03-10 | 1994-03-02 | New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning |
JP51955394A JP3957742B2 (ja) | 1993-03-10 | 1994-03-02 | グルタミン酸およびアスパラギン酸の新規誘導体、その製造方法およびその記憶力および学習力の増強用医薬品としての用途 |
AT94909905T ATE173461T1 (de) | 1993-03-10 | 1994-03-02 | Glutaminsäure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung zur steigerung des erinnerungsvermögens und der lernfähigkeit |
EP94909905A EP0688312B1 (en) | 1993-03-10 | 1994-03-02 | New derivatives of glutamic acid, a method of preparing them, and their use as drugs for enhancing memory and learning |
DE69414695T DE69414695T2 (de) | 1993-03-10 | 1994-03-02 | Glutaminsäure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung zur steigerung des erinnerungsvermögens und der lernfähigkeit |
PCT/EP1994/000604 WO1994020454A1 (en) | 1993-03-10 | 1994-03-02 | New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning |
ES94909905T ES2128554T3 (es) | 1993-03-10 | 1994-03-02 | Nuevos derivados del acido glutamico, procedimiento para su preparacion y su utilizacion como medicamentos para el aumento de la memoria y aprendizaje. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93TO000167A IT1264765B1 (it) | 1993-03-10 | 1993-03-10 | Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la |
Publications (3)
Publication Number | Publication Date |
---|---|
ITTO930167A0 true ITTO930167A0 (it) | 1993-03-10 |
ITTO930167A1 ITTO930167A1 (it) | 1994-09-10 |
IT1264765B1 IT1264765B1 (it) | 1996-10-04 |
Family
ID=11411249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93TO000167A IT1264765B1 (it) | 1993-03-10 | 1993-03-10 | Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la |
Country Status (10)
Country | Link |
---|---|
US (1) | US5723494A (it) |
EP (1) | EP0688312B1 (it) |
JP (1) | JP3957742B2 (it) |
AT (1) | ATE173461T1 (it) |
AU (1) | AU685438B2 (it) |
CA (1) | CA2156432C (it) |
DE (1) | DE69414695T2 (it) |
ES (1) | ES2128554T3 (it) |
IT (1) | IT1264765B1 (it) |
WO (1) | WO1994020454A1 (it) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1276462B1 (it) * | 1995-07-03 | 1997-10-31 | Rotta Research Lab | Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico |
IT1286141B1 (it) * | 1996-07-02 | 1998-07-07 | Rotta Research Lab | Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico. |
US6218383B1 (en) * | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
US20100222316A1 (en) * | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
ITTO20040343A1 (it) | 2004-05-24 | 2004-08-24 | Rotta Res Lab Spa | Uso di neboglamine (cr2249) come neuropsicotico e neuroprotettivo |
JP4564375B2 (ja) * | 2004-08-18 | 2010-10-20 | 太陽化学株式会社 | テアニンの製造方法 |
WO2006087232A1 (en) * | 2005-02-17 | 2006-08-24 | Instituto Del Metabolismo Celular, S.L. | L-aspartic acid for the treatment of problems in connection with the fat or glucose metabolism |
ITTO20050691A1 (it) | 2005-10-04 | 2007-04-05 | Rottapharm Spa | Uso di neboglamine nella terapia delle tossicodipendenze |
EP1903028A1 (en) * | 2006-09-22 | 2008-03-26 | Werner Tschollar | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects |
KR102239629B1 (ko) * | 2019-05-24 | 2021-04-12 | 이지원 | 실크 펩타이드의 제조방법 및 이를 이용하여 제조된 기억력 및 인지능력 개선용 조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1228272A (it) * | 1968-02-09 | 1971-04-15 | ||
US4053609A (en) * | 1975-09-12 | 1977-10-11 | Tanabe Seiyaku Co., Ltd. | Penicillins and processes for preparing the same |
JPS56131554A (en) * | 1980-03-17 | 1981-10-15 | Kaken Pharmaceut Co Ltd | Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component |
JPH06504031A (ja) * | 1988-09-30 | 1994-05-12 | オーストレイリアン・コマーシヤル・リサーチ・アンド・デイベロツプメント・リミテツド | アミノ酸輸送蛋白質、アミノ酸アナログ、アッセイ装置並びにその癌の治療及び診断への使用 |
WO1991012232A1 (en) * | 1990-02-06 | 1991-08-22 | Australian Commercial Research & Development Limited | Compounds and methods for the treatment and diagnosis of cancer |
JPH03294253A (ja) * | 1990-04-12 | 1991-12-25 | Shionogi & Co Ltd | 消化管ホルモン拮抗物質 |
AU8844891A (en) * | 1990-10-22 | 1992-05-20 | Universidad De Granada | Hydrolisis method and utilization of aminoacil-2-naphtylamide as diagnosis reagent |
IT1241029B (it) * | 1990-12-11 | 1993-12-27 | Rotta Research Lab | Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione |
-
1993
- 1993-03-10 IT IT93TO000167A patent/IT1264765B1/it active IP Right Grant
-
1994
- 1994-03-02 JP JP51955394A patent/JP3957742B2/ja not_active Expired - Fee Related
- 1994-03-02 AT AT94909905T patent/ATE173461T1/de not_active IP Right Cessation
- 1994-03-02 CA CA002156432A patent/CA2156432C/en not_active Expired - Fee Related
- 1994-03-02 ES ES94909905T patent/ES2128554T3/es not_active Expired - Lifetime
- 1994-03-02 EP EP94909905A patent/EP0688312B1/en not_active Expired - Lifetime
- 1994-03-02 AU AU62573/94A patent/AU685438B2/en not_active Ceased
- 1994-03-02 WO PCT/EP1994/000604 patent/WO1994020454A1/en active IP Right Grant
- 1994-03-02 US US08/513,964 patent/US5723494A/en not_active Expired - Lifetime
- 1994-03-02 DE DE69414695T patent/DE69414695T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3957742B2 (ja) | 2007-08-15 |
DE69414695T2 (de) | 1999-06-10 |
JPH08507502A (ja) | 1996-08-13 |
ITTO930167A1 (it) | 1994-09-10 |
DE69414695D1 (de) | 1998-12-24 |
EP0688312A1 (en) | 1995-12-27 |
CA2156432A1 (en) | 1994-09-15 |
WO1994020454A1 (en) | 1994-09-15 |
AU685438B2 (en) | 1998-01-22 |
IT1264765B1 (it) | 1996-10-04 |
ATE173461T1 (de) | 1998-12-15 |
ES2128554T3 (es) | 1999-05-16 |
AU6257394A (en) | 1994-09-26 |
EP0688312B1 (en) | 1998-11-18 |
US5723494A (en) | 1998-03-03 |
CA2156432C (en) | 2006-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |