GT199800114A - 4 - aminopirrol (3, 2-d) pirimidas como antagonistas del receptor del neuropeptido y. - Google Patents

4 - aminopirrol (3, 2-d) pirimidas como antagonistas del receptor del neuropeptido y.

Info

Publication number
GT199800114A
GT199800114A GT199800114A GT199800114A GT199800114A GT 199800114 A GT199800114 A GT 199800114A GT 199800114 A GT199800114 A GT 199800114A GT 199800114 A GT199800114 A GT 199800114A GT 199800114 A GT199800114 A GT 199800114A
Authority
GT
Guatemala
Prior art keywords
aminopyrol
pyrimids
antagonists
neuropeptide receptor
compounds
Prior art date
Application number
GT199800114A
Other languages
English (en)
Inventor
Robert Lee Dow
Marlyss Hammond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800114A publication Critical patent/GT199800114A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTA INVENCION SE REFIERE AL USO DE CIERTOS DERIVADOS DE 4 AMINOPIRROL (3, 2D) PIRIMIDA SUSTITUIDOS QUE SE UNEN DE FORMA SELECTIVA A RECEPTORES DE NEUROPEPTIDOS DE MAMIFEROS. SE REFIERE ADEMAS AL USO DE TALES COMPUESTOS Y COMPOSICIONES EN EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON UN EXCESO DE NEUROPEPTIDO Y, TALES COMO TRASTORNOS DE LA ALIMENTACION Y CIERTAS ENFERMEDADES CARDIOVASCULARES. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA QUIMICA ( I ), EN LA QUE B, D, E, F, G, R2 Y R3, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.
GT199800114A 1997-08-05 1998-07-27 4 - aminopirrol (3, 2-d) pirimidas como antagonistas del receptor del neuropeptido y. GT199800114A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5473497P 1997-08-05 1997-08-05

Publications (1)

Publication Number Publication Date
GT199800114A true GT199800114A (es) 2000-01-18

Family

ID=21993163

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800114A GT199800114A (es) 1997-08-05 1998-07-27 4 - aminopirrol (3, 2-d) pirimidas como antagonistas del receptor del neuropeptido y.

Country Status (32)

Country Link
US (1) US6187778B1 (es)
EP (1) EP1003744B1 (es)
JP (1) JP3711238B2 (es)
KR (1) KR20010022583A (es)
CN (1) CN1264381A (es)
AP (1) AP9801312A0 (es)
AT (1) ATE296825T1 (es)
AU (1) AU7927498A (es)
BG (1) BG104107A (es)
BR (1) BR9811844A (es)
CA (1) CA2293621C (es)
CO (1) CO4960634A1 (es)
DE (1) DE69830409T2 (es)
EA (1) EA200000098A1 (es)
ES (1) ES2241146T3 (es)
GT (1) GT199800114A (es)
HR (1) HRP980434A2 (es)
HU (1) HUP0002956A3 (es)
ID (1) ID24300A (es)
IL (1) IL133430A0 (es)
IS (1) IS5294A (es)
MA (1) MA24629A1 (es)
NO (1) NO996178L (es)
OA (1) OA11277A (es)
PA (1) PA8456601A1 (es)
PE (1) PE106199A1 (es)
PL (1) PL338575A1 (es)
SA (1) SA98190435A (es)
TN (1) TNSN98148A1 (es)
TR (1) TR200000333T2 (es)
WO (1) WO1999007703A1 (es)
ZA (1) ZA986968B (es)

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GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
MXPA06013996A (es) 2004-06-02 2007-02-08 Takeda Pharmaceutical Compuesto heterociclico fusionado.
NZ552093A (en) 2004-06-17 2009-06-26 Wyeth Corp Processes for preparing gonadotropin releasing hormone receptor antagonists
WO2006009734A1 (en) 2004-06-17 2006-01-26 Wyeth Gonadotropin releasing hormone receptor antagonists
US7465726B2 (en) * 2004-08-02 2008-12-16 Osi Pharmaceuticals, Inc. Substituted pyrrolo[2.3-B]pyridines
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
AU2006209117B2 (en) * 2005-01-28 2009-12-10 Daewoong Pharmaceutical Co., Ltd. Novel benzoimidazole derivatives and pharmaceutical composition comprising the same
KR20060087386A (ko) 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
AU2006235200A1 (en) * 2005-04-15 2006-10-19 Regenertech Pty Limited Use of Neuropeptide Y (NPY) and agonists and antagonists thereof for tissue regeneration
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
JP5281287B2 (ja) * 2005-07-13 2013-09-04 Ｍｓｄ株式会社 ヘテロ環置換ベンズイミダゾール誘導体
UY29823A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
EP1963320A1 (en) * 2005-12-07 2008-09-03 OSI Pharmaceuticals, Inc. Pyrrolopyridine kinase inhibiting compounds
ES2526813T3 (es) * 2005-12-22 2015-01-15 Cancer Research Technology Limited Inhibidores de enzimas
MX2008010611A (es) 2006-02-17 2008-11-12 Pfizer Ltd Derivados de 3-desazapurina como moduladores de receptores similares a toll.
WO2007125321A2 (en) 2006-04-25 2007-11-08 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
CA2656810C (en) * 2006-07-11 2012-03-13 Daewoong Pharmaceutical Co., Ltd. Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
KR101134239B1 (ko) 2006-07-11 2012-04-10 주식회사 대웅제약 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
WO2008121064A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
RS53552B1 (en) 2007-10-11 2015-02-27 Astrazeneca Ab DERIVATI PIROLO [2,3-D] PIRIMIDINA KAO INHIBITORI PROTEIN KINAZE B
CN101965350A (zh) 2008-01-11 2011-02-02 纳科法尔马有限公司 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物
AU2012235902B2 (en) 2011-04-01 2015-08-27 Astrazeneca Ab Therapeutic treatment
JP6309454B2 (ja) 2011-11-30 2018-04-11 アストラゼネカ アクチボラグ 癌の併用処置
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
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Also Published As

Publication number Publication date
AP9801312A0 (en) 2000-01-30
EP1003744A1 (en) 2000-05-31
CA2293621A1 (en) 1999-02-18
OA11277A (en) 2003-07-29
HUP0002956A3 (en) 2002-01-28
DE69830409T2 (de) 2006-01-26
ID24300A (id) 2000-07-13
NO996178D0 (no) 1999-12-14
CN1264381A (zh) 2000-08-23
ATE296825T1 (de) 2005-06-15
CO4960634A1 (es) 2000-09-25
CA2293621C (en) 2003-12-30
IL133430A0 (en) 2001-04-30
HRP980434A2 (en) 1999-04-30
US6187778B1 (en) 2001-02-13
NO996178L (no) 2000-02-14
EP1003744B1 (en) 2005-06-01
AU7927498A (en) 1999-03-01
ZA986968B (en) 2000-02-04
PE106199A1 (es) 1999-11-02
EA200000098A1 (ru) 2000-08-28
BR9811844A (pt) 2000-08-08
MA24629A1 (fr) 1999-04-01
JP2001512729A (ja) 2001-08-28
KR20010022583A (ko) 2001-03-26
PA8456601A1 (es) 2000-05-24
TR200000333T2 (tr) 2000-05-22
IS5294A (is) 1999-12-10
DE69830409D1 (de) 2005-07-07
HUP0002956A2 (hu) 2001-08-28
SA98190435A (ar) 2005-12-03
TNSN98148A1 (fr) 2005-03-15
BG104107A (bg) 2000-08-31
PL338575A1 (en) 2000-11-06
JP3711238B2 (ja) 2005-11-02
ES2241146T3 (es) 2005-10-16
WO1999007703A1 (en) 1999-02-18

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