AR055669A1 - Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales. - Google Patents
Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.Info
- Publication number
- AR055669A1 AR055669A1 ARP060104308A ARP060104308A AR055669A1 AR 055669 A1 AR055669 A1 AR 055669A1 AR P060104308 A ARP060104308 A AR P060104308A AR P060104308 A ARP060104308 A AR P060104308A AR 055669 A1 AR055669 A1 AR 055669A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- optionally substituted
- ora
- nrbrc
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Un proceso para su preparacion y con intermediarios utilizados en los mismos, con formulaciones farmacéuticas que contienen dichos compuestos terapéuticamente activos y con el uso de dichos compuestos activos en terapia de enfermedades mentales y neurodegenerativas. Reivindicacion 1: un compuesto de la formula (1) en la cual X es como se muestra en el compuesto de formula (2) o Y; R1 está seleccionado entre H, halogeno, CN, CO2H, NO2, alquilo C1-3, haloalquilo C1-3, ORa, SO2NRbRc, C(O)NRbRc, CH2NRbRc, CH2ORh, SO2Ri y C(O)Rj; R2 y R4 están seleccionados de manera independiente entre H, halo, CN, NO2, alquilo C1-3, haloalquilo C1-3, ORa, SO2NRbRc, C(O)NRbRc, CH2NRbRc, CH2ORh, SO2Ri y C(O)Rj; R3 y R5 están seleccionados de manera independiente entre H, alquilo C1-3 y haloalquilo C1-3; A es arilo o heteroarilo optativamente sustituido con uno o más CN, CO2H, alquilo C1-6, haloalquilo C1-6, halo, C(O)Ra, ORk, ORa, C(O)NRbRc, o S(O)nRm, donde dicho alquilo C1-6 o haloalquilo C1-6 está optativamente sustituido con por lo menos un CN, ORa o NRbRc; Y está seleccionado entre Z, alquilo C1-6, CH2ORd y CH2Z; Z es heteroarilo optativamente sustituido con uno o más CN, alquilo C1-6, haloalquilo C1-6, halo, C(O)Ra, ORk, C(O)NRbRc, o S(O)nRm, donde dicho alquilo C1-6 o haloalquilo C1-6 está optativamente sustituido con por lo menos un CN, ORa o NRbRc; Ra está seleccionado entre H, alquilo C1-3 y haloalquilo C1-3, donde dicho alquilo C1-3 o haloalquilo C1-3 está optativamente sustituido con uno o más alcoxi C1-3; Rb y Rc están seleccionados de manera independiente entre H, heteroarilo, alquilo C1-6 y haloalquilo C1-6, donde dicho alquilo C1-6 o haloalquilo C1-6 está optativamente sustituido con uno o más CN, ORa o NRdRe; o Rb y Rc pueden formar, junto con el átomo al cual están unidos, un anillo heterocíclico de 4, 5, 6 o 7 miembros que contiene uno o más heteroátomos seleccionados entre N, O o S, donde dicho anillo heterocíclico está optativamente sustituido con uno o más halo, ORa, NRdRe, alquilo C1-3 o haloalquilo C1-3, donde dicho alquilo C1-3 o haloalquilo C1-3 está optativamente sustituido a su vez con uno o más alcoxi C1-3; Rd y Re están seleccionados de manera independiente entre H, alquilo C1-6 o haloalquilo C1-6, donde dicho alquilo C1-6 o haloalquilo C1-6 está optativamente sustituido con uno o más ORa; o Rd y Re pueden formar, junto con el átomo al cual están unidos, un anillo heterocíclico de 4, 5, 6 o 7 miembros que contiene uno o más heteroátomos seleccionados entre N, O o S, donde dicho anillo heterocíclico está optativamente sustituido con uno o más halo, alquilo C1-3 o haloalquilo C1-3, donde dicho alquilo C1-3 o haloalquilo C1-3 está optativamente sustituido a su vez con uno o más alcoxi C1-3; Rh es H, alquilo C1-3 o haloalquilo C1-3 optativamente sustituido con uno o más alcoxi C1-3; Ri es alquilo C1-3 o haloalquilo C1-3, donde dicho alquilo C1-3 o haloalquilo C1-3 está optativamente sustituido con uno o más ORa; Rj es arilo o heteroarilo, donde dicho arilo o heteroarilo está optativamente sustituido con uno o más de alquilo C1-3, ORa, halo o CN; Rk es alquilo C1-6 o haloalquilo C1-6, donde dicho alquilo C1-6 o haloalquilo C1-6 está optativamente sustituido con por lo menos un CN, ORa, NRbRc, C(O)NRbRc o NRbC(O)Rc; Rm es alquilo C1-3 optativamente sustituido con por lo menos un halo, CN, ORa, NRbRc o C(O)NRbRc; n es 0 a 2; en forma de base libre o de una sal, solvato o solvato de la sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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SE0502172 | 2005-10-03 |
Publications (1)
Publication Number | Publication Date |
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AR055669A1 true AR055669A1 (es) | 2007-08-29 |
Family
ID=37906577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104308A AR055669A1 (es) | 2005-10-03 | 2006-09-29 | Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080255085A1 (es) |
EP (1) | EP1937680A4 (es) |
JP (1) | JP2009510161A (es) |
KR (1) | KR20080059285A (es) |
CN (1) | CN101321753A (es) |
AR (1) | AR055669A1 (es) |
AU (1) | AU2006297948B2 (es) |
BR (1) | BRPI0616672A2 (es) |
CA (1) | CA2624649A1 (es) |
EC (1) | ECSP088404A (es) |
IL (1) | IL189980A0 (es) |
NO (1) | NO20082065L (es) |
RU (1) | RU2008110913A (es) |
TW (1) | TW200745111A (es) |
UY (1) | UY29825A1 (es) |
WO (1) | WO2007040438A2 (es) |
ZA (1) | ZA200802898B (es) |
Families Citing this family (63)
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UY29823A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones |
ATE533485T1 (de) † | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
KR20090071662A (ko) | 2006-10-21 | 2009-07-01 | 애보트 게엠베하 운트 콤파니 카게 | 헤테로사이클릭 화합물 및 글리코겐 신타제 키나제 3 억제제로서의 이의 용도 |
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WO2009017453A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | New therapeutic combination of an antipsychotic and a gsk3 inhibitor 958 |
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DK3562487T3 (da) * | 2016-12-29 | 2024-01-02 | Ji Xing Pharmaceuticals Hong Kong Ltd | Metalloenzyminhibitorforbindelser |
EP3562306A4 (en) | 2016-12-29 | 2020-06-24 | Selenity Therapeutics (Bermuda), Ltd. | METALLOENZYME INHIBITOR COMPOUNDS |
US11447488B2 (en) | 2017-10-06 | 2022-09-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
WO2019108418A1 (en) | 2017-11-30 | 2019-06-06 | Landos Biopharma, Inc. | Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith |
EP3976612A4 (en) * | 2019-05-28 | 2023-04-26 | Mankind Pharma Ltd | NEW COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 |
WO2021127472A1 (en) | 2019-12-20 | 2021-06-24 | Landos Biopharma, Inc. | Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same |
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ATE296825T1 (de) * | 1997-08-05 | 2005-06-15 | Pfizer Prod Inc | 4-aminopyrrole(3,2-d)pyrimidine als neuropeptid rezeptor antagonisten |
US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
MXPA04006614A (es) * | 2002-01-07 | 2004-10-04 | Eisai Co Ltd | Deazapurinas y usos de las mismas. |
KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Gsk-3의 억제제로서 유용한 헤테로아릴 화합물 |
MXPA04009283A (es) * | 2002-03-27 | 2005-01-25 | Altana Pharma Ag | Nuevos derivados de alcoxipiridina. |
SE0202462D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel use |
KR100791252B1 (ko) * | 2003-01-23 | 2008-01-03 | 크리스탈지노믹스(주) | 글리코겐 합성효소 키나아제 3β 활성 억제제, 이의제조방법 및 이를 유효성분으로 함유하는 약학 조성물 |
US7279488B2 (en) * | 2003-10-01 | 2007-10-09 | Nycomed Gmbh | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
KR20060092220A (ko) * | 2003-10-01 | 2006-08-22 | 알타나 파마 아게 | 유도성 no-신타아제 저해제로서의 이미다조피리딘 유도체 |
UY29823A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones |
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2006
- 2006-09-29 AR ARP060104308A patent/AR055669A1/es not_active Application Discontinuation
- 2006-09-29 UY UY29825A patent/UY29825A1/es unknown
- 2006-10-02 AU AU2006297948A patent/AU2006297948B2/en not_active Ceased
- 2006-10-02 JP JP2008534484A patent/JP2009510161A/ja active Pending
- 2006-10-02 EP EP06799714A patent/EP1937680A4/en not_active Withdrawn
- 2006-10-02 CN CNA2006800453113A patent/CN101321753A/zh active Pending
- 2006-10-02 CA CA002624649A patent/CA2624649A1/en not_active Abandoned
- 2006-10-02 US US12/089,002 patent/US20080255085A1/en not_active Abandoned
- 2006-10-02 RU RU2008110913/04A patent/RU2008110913A/ru not_active Application Discontinuation
- 2006-10-02 WO PCT/SE2006/001114 patent/WO2007040438A2/en active Application Filing
- 2006-10-02 BR BRPI0616672-5A patent/BRPI0616672A2/pt not_active IP Right Cessation
- 2006-10-02 KR KR1020087010753A patent/KR20080059285A/ko not_active Application Discontinuation
- 2006-10-03 TW TW095136775A patent/TW200745111A/zh unknown
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2008
- 2008-03-06 IL IL189980A patent/IL189980A0/en unknown
- 2008-04-02 ZA ZA200802898A patent/ZA200802898B/xx unknown
- 2008-04-28 EC EC2008008404A patent/ECSP088404A/es unknown
- 2008-04-30 NO NO20082065A patent/NO20082065L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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EP1937680A4 (en) | 2010-08-18 |
CN101321753A (zh) | 2008-12-10 |
EP1937680A2 (en) | 2008-07-02 |
US20080255085A1 (en) | 2008-10-16 |
JP2009510161A (ja) | 2009-03-12 |
UY29825A1 (es) | 2007-05-31 |
AU2006297948A1 (en) | 2007-04-12 |
ECSP088404A (es) | 2008-05-30 |
TW200745111A (en) | 2007-12-16 |
CA2624649A1 (en) | 2007-04-12 |
WO2007040438A3 (en) | 2007-05-31 |
AU2006297948B2 (en) | 2010-02-11 |
BRPI0616672A2 (pt) | 2011-06-28 |
WO2007040438A2 (en) | 2007-04-12 |
IL189980A0 (en) | 2008-08-07 |
KR20080059285A (ko) | 2008-06-26 |
RU2008110913A (ru) | 2009-11-10 |
ZA200802898B (en) | 2009-02-25 |
NO20082065L (no) | 2008-07-02 |
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