AR040352A1 - Derivados de indolinfenilsulfonamida - Google Patents

Derivados de indolinfenilsulfonamida

Info

Publication number
AR040352A1
AR040352A1 ARP030102373A ARP030102373A AR040352A1 AR 040352 A1 AR040352 A1 AR 040352A1 AR P030102373 A ARP030102373 A AR P030102373A AR P030102373 A ARP030102373 A AR P030102373A AR 040352 A1 AR040352 A1 AR 040352A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
represents hydrogen
alkoxy
amino
Prior art date
Application number
ARP030102373A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of AR040352A1 publication Critical patent/AR040352A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se refiere a derivados sustituidos de indolinfenilsulfonamida, a procedimientos para su preparación así como a su uso en medicamentos, especialmente como potentes compuestos activadores de PPAR-d, para la profilaxis y/o el tratamiento de enfermedades cardiovasculares, especialmente de dislipidemias y enfermedades cardíacas coronarias. Reivindicación 1: Compuestos de fórmula general (1) en la que A representa el grupo C-R11 o N, en la que R11 representa hidrógeno o alquilo (C1-4), X representa O, S o CH2, R1 representa arilo (C6-10) o heteroarilo de 5 a 10 miembros con hasta tres heteroátomos del grupo de N, O y S, que pueden estar sustituidos a su vez respectivamente una a tres veces de forma igual o distinta con sustituyentes seleccionados del grupo de halógeno, ciano, nitro, alquilo (C1-6) que a su vez puede estar sustituido con hidroxi, alcoxi (C1-6), fenoxi, benciloxi, trifluormetilo, trifluormetoxi, alquelino (C2-6), fenilo, bencilo, alquil (C1-6)tio, alquil (C1-6)sulfonilo, alcanoilo (C1-6), alcoxi (C1-6)carbonilo, carboxilo, amino, acil (C1-6)amino, mono- y dialquil (C1-6)amino y heterociclilo de 5 a 6 miembros con hasta dos heteroátomos del grupo de N, O y/o S, o representa un grupo de la fórmula (2), R2 y R3 son iguales o distintos y representan independientemente entre sí hidrógeno o alquilo (C1-6) o, conjuntamente con el átomo de carbono al que están unidos, forman un anillo cicloalquilo con unión espiro de 3 a 7 miembros, R4 representa hidrógeno o alquilo (C1-6), R5 representa hidrógeno o alquilo (C1-6), R6 representa hidrógeno o alquilo (C1-6), R7 representa hidrógeno, alquilo (C1-6), alcoxi (C1-6) o halógeno, R8 y R9 son iguales o distintos y representan independientemente entre sí hidrógeno o alquilo (C1-4), y R10 representa hidrógeno o un grupo hidrolizable que puede degradarse al correspondiente ácido carboxílico, así como sus sales, solvatos y solvatos de las sales farmacéuticamente aceptables.
ARP030102373A 2002-07-03 2003-06-30 Derivados de indolinfenilsulfonamida AR040352A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10229777A DE10229777A1 (de) 2002-07-03 2002-07-03 Indolin-Phenylsulfonamid-Derivate

Publications (1)

Publication Number Publication Date
AR040352A1 true AR040352A1 (es) 2005-03-30

Family

ID=29796112

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030102373A AR040352A1 (es) 2002-07-03 2003-06-30 Derivados de indolinfenilsulfonamida

Country Status (26)

Country Link
US (1) US20060100230A1 (es)
EP (1) EP1519919A1 (es)
JP (1) JP2005535649A (es)
CN (1) CN1678581A (es)
AR (1) AR040352A1 (es)
AU (1) AU2003246638A1 (es)
BR (1) BR0312549A (es)
CA (1) CA2491477A1 (es)
DE (1) DE10229777A1 (es)
EC (1) ECSP055524A (es)
GT (1) GT200300135A (es)
HN (1) HN2003000196A (es)
HR (1) HRP20050108A2 (es)
IL (1) IL165924A0 (es)
MA (1) MA27316A1 (es)
MX (1) MXPA05000133A (es)
MY (1) MY134641A (es)
NO (1) NO20050579L (es)
NZ (1) NZ537486A (es)
PE (1) PE20040645A1 (es)
RU (1) RU2328485C2 (es)
TW (1) TW200418794A (es)
UA (1) UA79003C2 (es)
UY (1) UY27878A1 (es)
WO (1) WO2004005253A1 (es)
ZA (1) ZA200500013B (es)

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* Cited by examiner, † Cited by third party
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DE10335450A1 (de) * 2003-08-02 2005-02-17 Bayer Ag Indolin-Sulfanilsäureamide
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ES2352085T3 (es) 2004-05-05 2011-02-15 High Point Pharmaceuticals, Llc Nuevos compuestos, su preparación y uso.
WO2005105736A1 (en) 2004-05-05 2005-11-10 Novo Nordisk A/S Novel compounds, their preparation and use
FR2869904B1 (fr) 2004-05-07 2006-07-28 Fournier S A Sa Lab Modulateurs des recepteurs lxr
FR2873694B1 (fr) * 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si Nouveaux aza-indoles inhibiteurs de la mtp et apob
CN101421258B (zh) * 2004-10-29 2013-08-21 凯利普西斯公司 作为ppar调节剂的磺酰基取代的双环化合物
EP1805158B1 (en) * 2004-10-29 2018-06-27 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
BRPI0606492A2 (pt) * 2005-01-18 2009-06-30 Novartis Ag método de uso de compostos agonistas duplos de ppars e dispositivos para distribuição de fármacos que contêm tais compostos
DE102005020229A1 (de) * 2005-04-30 2006-11-09 Bayer Healthcare Ag Verwendung von Indolin-Phenylsulfonamid-Derivaten
DE102005020230A1 (de) * 2005-04-30 2006-11-09 Bayer Healthcare Ag Verwendung von Indolin-Phenylsulfonamid-Derivaten
FR2886293B1 (fr) * 2005-05-30 2007-08-24 Fournier S A Sa Lab Nouveaux composes de l'indoline
BRPI0612730A2 (pt) 2005-06-30 2010-11-30 Novo Nordisk As compostos, suas preparações e uso
FR2890072A1 (fr) * 2005-09-01 2007-03-02 Fournier S A Sa Lab Nouveaux composesde pyrrolopyridine
US7943613B2 (en) 2005-12-22 2011-05-17 High Point Pharmaceuticals, Llc Compounds, their preparation and use
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EP1932843A1 (en) 2006-12-14 2008-06-18 sanofi-aventis Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals
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TW200848021A (en) 2007-03-06 2008-12-16 Wyeth Corp Sulfonylated heterocycles useful for modulation of the progesterone receptor
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EP2288607B1 (en) 2008-06-09 2014-09-24 Sanofi Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals
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CN102264228A (zh) 2008-10-22 2011-11-30 默沙东公司 用于抗糖尿病药的新的环状苯并咪唑衍生物
AU2009309037A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EA022623B1 (ru) 2010-10-06 2016-02-29 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Производные бензимидазола в качестве ингибиторов pi3-киназ
EP2638014B1 (en) 2010-11-08 2017-01-04 Lycera Corporation N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases
ES2652662T3 (es) 2011-02-25 2018-02-05 Merck Sharp & Dohme Corp. Novedosos derivados de azabencimidazol cíclicos útiles como agentes antidiabéticos
US9657033B2 (en) * 2012-05-08 2017-05-23 Lycera Corporation Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease
WO2013169864A2 (en) * 2012-05-08 2013-11-14 Lycera Corporation TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE
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JP2017507950A (ja) 2014-02-27 2017-03-23 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法
AU2015256190B2 (en) 2014-05-05 2019-08-15 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease
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US10421751B2 (en) 2015-05-05 2019-09-24 Lycera Corporation Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
CN107980042B (zh) 2015-06-11 2021-10-08 莱斯拉公司 用作RORγ激动剂和用于治疗疾病的芳基二氢-2H-苯并[b][1,4]噁嗪磺酰胺和相关化合物
US10344000B2 (en) 2015-10-27 2019-07-09 Merck Sharp & Dohme Corp. Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
RU2018117503A (ru) 2015-10-27 2019-11-28 Мерк Шарп И Доум Корп. ЗАМЕЩЕННЫЕ ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORγТ И ИХ ПРИМЕНЕНИЕ
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CN110627785B (zh) * 2019-09-19 2021-06-25 温州大学 一种1,5-四氢萘啶衍生物的制备方法
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KR100266467B1 (ko) * 1995-09-27 2000-10-02 우에노 도시오 설폰아미드 유도체
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
US6787552B2 (en) * 2000-08-11 2004-09-07 Nippon Chemiphar Co., Ltd. PPAR delta activators

Also Published As

Publication number Publication date
US20060100230A1 (en) 2006-05-11
NZ537486A (en) 2006-07-28
TW200418794A (en) 2004-10-01
MXPA05000133A (es) 2005-04-11
IL165924A0 (en) 2006-01-15
HRP20050108A2 (hr) 2006-04-30
CN1678581A (zh) 2005-10-05
BR0312549A (pt) 2005-04-26
MA27316A1 (fr) 2005-05-02
CA2491477A1 (en) 2004-01-15
RU2005102592A (ru) 2005-07-10
MY134641A (en) 2007-12-31
ECSP055524A (es) 2005-03-10
EP1519919A1 (de) 2005-04-06
GT200300135A (es) 2004-03-17
UA79003C2 (en) 2007-05-10
AU2003246638A1 (en) 2004-01-23
DE10229777A1 (de) 2004-01-29
PE20040645A1 (es) 2004-10-29
NO20050579L (no) 2005-02-02
UY27878A1 (es) 2004-02-27
JP2005535649A (ja) 2005-11-24
WO2004005253A1 (de) 2004-01-15
HN2003000196A (es) 2004-11-22
ZA200500013B (en) 2006-03-29
RU2328485C2 (ru) 2008-07-10

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