PE20040645A1 - Derivados de indolinfenilsulfonamida - Google Patents
Derivados de indolinfenilsulfonamidaInfo
- Publication number
- PE20040645A1 PE20040645A1 PE2003000668A PE2003000668A PE20040645A1 PE 20040645 A1 PE20040645 A1 PE 20040645A1 PE 2003000668 A PE2003000668 A PE 2003000668A PE 2003000668 A PE2003000668 A PE 2003000668A PE 20040645 A1 PE20040645 A1 PE 20040645A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- indolinfenylsulfonamide
- derivatives
- compounds
- alcoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE INDOLINFENILSULFONAMIDA DE FORMULA I DONDE A ES -CH-, N, C-ALQUILO C1-C4; X ES O, S, CH2; R1 ES ARILO C6-C10 O HETEROARILO DE 5-10 MIEMBROS, ENTRE OTROS; R2 Y R3 SON CADA UNO H, ALQUILO C1-C6, ENTRE OTROS; R4, R5 Y R6 SON CADA UNO H O ALQUILO C1-C6; R7 ES H, ALQUILO C1-C6, ALCOXI C1-C6, HALOGENO; R8 Y R9 SON CADA UNO H O ALQUILO C1-C4; R10 ES H O UN GRUPO HIDROLIZABLE A ACIDO CARBOXILICO. DICHOS COMPUESTOS SON UTILES EN LA PROFILAXIS Y TRATAMIENTO DE ARTERIOSCLEROSIS, INFARTO DE MIOCARDIO Y DISLIPIDEMIAS, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10229777A DE10229777A1 (de) | 2002-07-03 | 2002-07-03 | Indolin-Phenylsulfonamid-Derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040645A1 true PE20040645A1 (es) | 2004-10-29 |
Family
ID=29796112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000668A PE20040645A1 (es) | 2002-07-03 | 2003-07-02 | Derivados de indolinfenilsulfonamida |
Country Status (26)
Country | Link |
---|---|
US (1) | US20060100230A1 (es) |
EP (1) | EP1519919A1 (es) |
JP (1) | JP2005535649A (es) |
CN (1) | CN1678581A (es) |
AR (1) | AR040352A1 (es) |
AU (1) | AU2003246638A1 (es) |
BR (1) | BR0312549A (es) |
CA (1) | CA2491477A1 (es) |
DE (1) | DE10229777A1 (es) |
EC (1) | ECSP055524A (es) |
GT (1) | GT200300135A (es) |
HN (1) | HN2003000196A (es) |
HR (1) | HRP20050108A2 (es) |
IL (1) | IL165924A0 (es) |
MA (1) | MA27316A1 (es) |
MX (1) | MXPA05000133A (es) |
MY (1) | MY134641A (es) |
NO (1) | NO20050579L (es) |
NZ (1) | NZ537486A (es) |
PE (1) | PE20040645A1 (es) |
RU (1) | RU2328485C2 (es) |
TW (1) | TW200418794A (es) |
UA (1) | UA79003C2 (es) |
UY (1) | UY27878A1 (es) |
WO (1) | WO2004005253A1 (es) |
ZA (1) | ZA200500013B (es) |
Families Citing this family (58)
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DE10335450A1 (de) * | 2003-08-02 | 2005-02-17 | Bayer Ag | Indolin-Sulfanilsäureamide |
DE10337839A1 (de) * | 2003-08-18 | 2005-03-17 | Bayer Healthcare Ag | Indolin-Derivate |
CN1878773A (zh) * | 2003-09-05 | 2006-12-13 | 神经能质公司 | 作为crf1受体配位体的杂芳基稠合的吡啶,吡嗪及嘧啶 |
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US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
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FR2873694B1 (fr) * | 2004-07-27 | 2006-12-08 | Merck Sante Soc Par Actions Si | Nouveaux aza-indoles inhibiteurs de la mtp et apob |
CN101421258B (zh) * | 2004-10-29 | 2013-08-21 | 凯利普西斯公司 | 作为ppar调节剂的磺酰基取代的双环化合物 |
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US20080131475A1 (en) * | 2005-01-18 | 2008-06-05 | David Saul Cohen | Methods of Use of Dual Ppar Agonist Compounds and Drug Delivery Devices Containing Such Compounds |
DE102005020229A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
DE102005020230A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
FR2886293B1 (fr) * | 2005-05-30 | 2007-08-24 | Fournier S A Sa Lab | Nouveaux composes de l'indoline |
EP2298742B1 (en) | 2005-06-30 | 2014-01-08 | High Point Pharmaceuticals, LLC | phenoxy acetic acids as PPAR delta activators |
FR2890072A1 (fr) | 2005-09-01 | 2007-03-02 | Fournier S A Sa Lab | Nouveaux composesde pyrrolopyridine |
BRPI0620468A2 (pt) | 2005-12-22 | 2011-11-08 | Transtech Pharma Inc | ácidos fenóxi acéticos como ativadores de ppar delta |
CA2645719A1 (en) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
TWI315304B (en) * | 2006-08-31 | 2009-10-01 | Univ Taipei Medical | Indoline-sulfonamides compounds |
EP1932843A1 (en) * | 2006-12-14 | 2008-06-18 | sanofi-aventis | Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals |
US20080176861A1 (en) | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
WO2010000353A1 (en) * | 2008-06-09 | 2010-01-07 | Sanofi-Aventis | Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
MX2010013264A (es) * | 2008-06-09 | 2011-02-25 | Sanofi Aventis | Sulfonamidas n-heterociclicas aneladas con grupo de cabeza de oxadiazolona, procesos para su preparacion y su uso como sustancias farmaceuticas. |
EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US20130196990A1 (en) | 2010-10-06 | 2013-08-01 | Junya Qu | Benzimidazole Derivatives As PI3 Kinase Inhibitors |
JP6063870B2 (ja) | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | RORγ活性の阻害用のN−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
MX348131B (es) | 2011-02-25 | 2017-05-26 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos. |
CA2871514C (en) | 2012-05-08 | 2020-08-25 | Merck Sharp & Dohme Corp. | Tetrahydronaphthyridine and related bicyclic compounds for inhibition of ror.gamma.activity and the treatment of disease |
US9394315B2 (en) | 2012-05-08 | 2016-07-19 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US9840512B2 (en) | 2013-02-22 | 2017-12-12 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
JP6192836B2 (ja) * | 2013-07-30 | 2017-09-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Rorcモジュレーターとしてのアザインドール化合物 |
WO2015035171A1 (en) | 2013-09-09 | 2015-03-12 | High Point Pharmaceuticals, Llc | Use of a ppar-delta agonist for treating muscle atrophy |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
CN103626767A (zh) * | 2013-12-04 | 2014-03-12 | 上海药明康德新药开发有限公司 | 区域选择性的氮杂吲哚及其合成方法 |
WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
US9663502B2 (en) | 2013-12-20 | 2017-05-30 | Lycera Corporation | 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease |
WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
CN106132422A (zh) | 2014-02-27 | 2016-11-16 | 莱斯拉公司 | 使用视黄酸受体相关孤儿受体γ的激动剂的过继细胞疗法&相关治疗方法 |
JP6523337B2 (ja) | 2014-05-05 | 2019-05-29 | リセラ・コーポレイションLycera Corporation | RORγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物 |
US9896441B2 (en) | 2014-05-05 | 2018-02-20 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
JP2018510135A (ja) | 2015-02-11 | 2018-04-12 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγT阻害剤としての置換ピラゾール化合物及びその使用 |
JP2018515491A (ja) | 2015-05-05 | 2018-06-14 | リセラ・コーポレイションLycera Corporation | RORγの作動薬及び疾患の療法として使用するジヒドロ−2H−ベンゾ[b][1,4]オキサジンスルホンアミド及び関連化合物 |
CN107980042B (zh) | 2015-06-11 | 2021-10-08 | 莱斯拉公司 | 用作RORγ激动剂和用于治疗疾病的芳基二氢-2H-苯并[b][1,4]噁嗪磺酰胺和相关化合物 |
JP2018535958A (ja) | 2015-10-27 | 2018-12-06 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγT阻害薬としての置換インダゾール化合物及びその使用 |
AU2016344111A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof |
EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
CN110483509B (zh) * | 2019-09-04 | 2020-08-25 | 温州大学 | 一种合成含氮杂环衍生物的方法 |
CN110627785B (zh) * | 2019-09-19 | 2021-06-25 | 温州大学 | 一种1,5-四氢萘啶衍生物的制备方法 |
WO2021126779A1 (en) * | 2019-12-18 | 2021-06-24 | The Regents Of The University Of California | Inhibitors of lin28 and methods of use thereof |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US5795890A (en) * | 1995-09-27 | 1998-08-18 | Ono Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
JP4790969B2 (ja) * | 2000-08-11 | 2011-10-12 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
-
2002
- 2002-07-03 DE DE10229777A patent/DE10229777A1/de not_active Withdrawn
-
2003
- 2003-06-30 CA CA002491477A patent/CA2491477A1/en not_active Abandoned
- 2003-06-30 US US10/519,125 patent/US20060100230A1/en not_active Abandoned
- 2003-06-30 CN CNA038209446A patent/CN1678581A/zh active Pending
- 2003-06-30 WO PCT/EP2003/006896 patent/WO2004005253A1/de not_active Application Discontinuation
- 2003-06-30 RU RU2005102592/04A patent/RU2328485C2/ru not_active IP Right Cessation
- 2003-06-30 AR ARP030102373A patent/AR040352A1/es not_active Application Discontinuation
- 2003-06-30 JP JP2004518622A patent/JP2005535649A/ja not_active Withdrawn
- 2003-06-30 AU AU2003246638A patent/AU2003246638A1/en not_active Abandoned
- 2003-06-30 UA UAA200500952A patent/UA79003C2/uk unknown
- 2003-06-30 MX MXPA05000133A patent/MXPA05000133A/es unknown
- 2003-06-30 NZ NZ537486A patent/NZ537486A/en unknown
- 2003-06-30 EP EP03762547A patent/EP1519919A1/de not_active Withdrawn
- 2003-06-30 BR BR0312549-1A patent/BR0312549A/pt not_active IP Right Cessation
- 2003-07-01 MY MYPI20032474A patent/MY134641A/en unknown
- 2003-07-02 TW TW092118027A patent/TW200418794A/zh unknown
- 2003-07-02 PE PE2003000668A patent/PE20040645A1/es not_active Application Discontinuation
- 2003-07-02 UY UY27878A patent/UY27878A1/es not_active Application Discontinuation
- 2003-07-02 HN HN2003000196A patent/HN2003000196A/es unknown
- 2003-07-02 GT GT200300135A patent/GT200300135A/es unknown
-
2004
- 2004-12-22 IL IL16592404A patent/IL165924A0/xx unknown
-
2005
- 2005-01-03 EC EC2005005524A patent/ECSP055524A/es unknown
- 2005-01-03 ZA ZA200500013A patent/ZA200500013B/en unknown
- 2005-01-03 MA MA28032A patent/MA27316A1/fr unknown
- 2005-02-02 HR HR20050108A patent/HRP20050108A2/hr not_active Application Discontinuation
- 2005-02-02 NO NO20050579A patent/NO20050579L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1519919A1 (de) | 2005-04-06 |
CA2491477A1 (en) | 2004-01-15 |
RU2005102592A (ru) | 2005-07-10 |
HRP20050108A2 (hr) | 2006-04-30 |
UY27878A1 (es) | 2004-02-27 |
DE10229777A1 (de) | 2004-01-29 |
CN1678581A (zh) | 2005-10-05 |
MXPA05000133A (es) | 2005-04-11 |
UA79003C2 (en) | 2007-05-10 |
WO2004005253A1 (de) | 2004-01-15 |
NO20050579L (no) | 2005-02-02 |
GT200300135A (es) | 2004-03-17 |
IL165924A0 (en) | 2006-01-15 |
MY134641A (en) | 2007-12-31 |
HN2003000196A (es) | 2004-11-22 |
TW200418794A (en) | 2004-10-01 |
NZ537486A (en) | 2006-07-28 |
JP2005535649A (ja) | 2005-11-24 |
RU2328485C2 (ru) | 2008-07-10 |
MA27316A1 (fr) | 2005-05-02 |
US20060100230A1 (en) | 2006-05-11 |
ZA200500013B (en) | 2006-03-29 |
AU2003246638A1 (en) | 2004-01-23 |
AR040352A1 (es) | 2005-03-30 |
BR0312549A (pt) | 2005-04-26 |
ECSP055524A (es) | 2005-03-10 |
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