ATE417841T1 - Furanderivate als ep4-rezeptorantagonisten - Google Patents

Furanderivate als ep4-rezeptorantagonisten

Info

Publication number
ATE417841T1
ATE417841T1 AT04768922T AT04768922T ATE417841T1 AT E417841 T1 ATE417841 T1 AT E417841T1 AT 04768922 T AT04768922 T AT 04768922T AT 04768922 T AT04768922 T AT 04768922T AT E417841 T1 ATE417841 T1 AT E417841T1
Authority
AT
Austria
Prior art keywords
optionally substituted
receptor antagonists
alkyl
group
furan derivatives
Prior art date
Application number
AT04768922T
Other languages
English (en)
Inventor
David Edward Clark
Neil Victor Harris
Garry Fenton
George Hynd
Keith Alfred James Stuttle
Jonathan Mark Sutton
Alexander William Oxford
Richard Jon Davis
Robert Alexander Coleman
Kenneth Lyle Clark
Original Assignee
Asterand Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asterand Uk Ltd filed Critical Asterand Uk Ltd
Application granted granted Critical
Publication of ATE417841T1 publication Critical patent/ATE417841T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
AT04768922T 2003-10-16 2004-10-15 Furanderivate als ep4-rezeptorantagonisten ATE417841T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0324269.0A GB0324269D0 (en) 2003-10-16 2003-10-16 EP4 receptor antagonists
US51220003P 2003-10-20 2003-10-20

Publications (1)

Publication Number Publication Date
ATE417841T1 true ATE417841T1 (de) 2009-01-15

Family

ID=29559424

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04768922T ATE417841T1 (de) 2003-10-16 2004-10-15 Furanderivate als ep4-rezeptorantagonisten

Country Status (9)

Country Link
US (3) US7569602B2 (de)
EP (1) EP1673360B1 (de)
JP (1) JP2007508364A (de)
CN (1) CN1894231B (de)
AT (1) ATE417841T1 (de)
AU (1) AU2004281225B2 (de)
CA (1) CA2542440A1 (de)
GB (1) GB0324269D0 (de)
WO (1) WO2005037812A1 (de)

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WO2010019796A1 (en) * 2008-08-14 2010-02-18 Chemietek, Llc Heterocyclic amide derivatives as ep4 receptor antagonists
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CA2929562A1 (en) * 2013-12-17 2015-06-25 Eli Lilly And Company Dimethylbenzoic acid compounds
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2018210987A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as pge2 receptor modulators
TWI768043B (zh) 2017-05-18 2022-06-21 瑞士商愛杜西亞製藥有限公司 N-取代吲哚衍生物
KR102632028B1 (ko) 2017-05-18 2024-01-31 이도르시아 파마슈티컬스 리미티드 Pge2 수용체 조절제로서의 페닐 유도체
EP3625223B1 (de) 2017-05-18 2021-08-11 Idorsia Pharmaceuticals Ltd Pyrimidinderivate
PE20191811A1 (es) 2017-05-18 2019-12-26 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
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US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

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CN1894231A (zh) 2007-01-10
US20050124676A1 (en) 2005-06-09
US7417068B2 (en) 2008-08-26
WO2005037812A1 (en) 2005-04-28
EP1673360B1 (de) 2008-12-17
US20070135503A1 (en) 2007-06-14
US7569602B2 (en) 2009-08-04
AU2004281225B2 (en) 2010-11-18
GB0324269D0 (en) 2003-11-19
CN1894231B (zh) 2011-10-05
EP1673360A1 (de) 2006-06-28
JP2007508364A (ja) 2007-04-05
US20080306117A1 (en) 2008-12-11
AU2004281225A1 (en) 2005-04-28
CA2542440A1 (en) 2005-04-28

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