ATE327751T1 - Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz - Google Patents
Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienzInfo
- Publication number
- ATE327751T1 ATE327751T1 AT01300690T AT01300690T ATE327751T1 AT E327751 T1 ATE327751 T1 AT E327751T1 AT 01300690 T AT01300690 T AT 01300690T AT 01300690 T AT01300690 T AT 01300690T AT E327751 T1 ATE327751 T1 AT E327751T1
- Authority
- AT
- Austria
- Prior art keywords
- acute
- receptor
- chronic renal
- prostagland
- activators
- Prior art date
Links
- 208000009304 Acute Kidney Injury Diseases 0.000 title abstract 2
- 208000033626 Renal failure acute Diseases 0.000 title abstract 2
- 230000001154 acute effect Effects 0.000 title abstract 2
- 208000020832 chronic kidney disease Diseases 0.000 title abstract 2
- 239000012190 activator Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 101150109738 Ptger4 gene Proteins 0.000 abstract 1
- 201000011040 acute kidney failure Diseases 0.000 abstract 1
- 208000012998 acute renal failure Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17896800P | 2000-01-31 | 2000-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE327751T1 true ATE327751T1 (de) | 2006-06-15 |
Family
ID=22654657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01300690T ATE327751T1 (de) | 2000-01-31 | 2001-01-25 | Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6610719B2 (de) |
| EP (1) | EP1132086B1 (de) |
| JP (2) | JP3839261B2 (de) |
| KR (1) | KR100419684B1 (de) |
| AT (1) | ATE327751T1 (de) |
| AU (1) | AU774569B2 (de) |
| CA (1) | CA2332687A1 (de) |
| CO (1) | CO5261529A1 (de) |
| CY (1) | CY1105299T1 (de) |
| DE (1) | DE60120007T2 (de) |
| DK (1) | DK1132086T3 (de) |
| ES (1) | ES2263557T3 (de) |
| HU (1) | HUP0100495A3 (de) |
| IL (1) | IL141120A0 (de) |
| NZ (1) | NZ509632A (de) |
| PE (1) | PE20011048A1 (de) |
| PT (1) | PT1132086E (de) |
| ZA (1) | ZA200100827B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001290250A1 (en) * | 2000-09-21 | 2002-04-02 | Ono Pharmaceutical Co. Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| IL155368A0 (en) | 2000-11-27 | 2003-11-23 | Pfizer Prod Inc | Ep4 receptor selective agonists in the treatment of osteoporosis |
| JP4211605B2 (ja) * | 2001-07-16 | 2009-01-21 | 小野薬品工業株式会社 | プロスタノイドアゴニストとしての2ピロリドン誘導体 |
| US7608637B2 (en) | 2001-07-23 | 2009-10-27 | Ono Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient |
| EP1439837B1 (de) | 2001-10-23 | 2008-04-09 | Laboratoires Serono SA | Pyrazolidinon-verbindungen als liganden des ep2 und/oder ep4 prostaglandin-rezeptoren |
| US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
| NZ535024A (en) | 2002-03-05 | 2006-10-27 | Ono Pharmaceutical Co | 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient |
| BR0308493A (pt) * | 2002-03-18 | 2005-01-11 | Pfizer Prod Inc | Uso de agonistas de receptor seletivo de ep4 para o tratamento da insuficiência hepática, perda de permeabilidade do canal arterial, glaucoma ou hipertensão ocular |
| US6573294B1 (en) | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| WO2003103772A1 (en) | 2002-06-06 | 2003-12-18 | Merck Frosst Canada & Co. | 1,5-distributed pyrrolid-2-one derivatives for use as ep4 receptor agonists in the teatment of eye diseases such as glaucoma |
| CA2483555A1 (en) * | 2002-06-10 | 2003-12-18 | Applied Research Systems Ars Holding N.V. | Gamma lactams as prostaglandin agonists and use thereof |
| ES2393321T3 (es) | 2002-10-10 | 2012-12-20 | Ono Pharmaceutical Co., Ltd. | Promotores de la producción de factores de reparación endógenos |
| FI20030015A0 (fi) * | 2003-01-03 | 2003-01-03 | Orion Corp | Menetelmä munuaisten vajaatoiminnan hoitamiseksi |
| JP4582456B2 (ja) * | 2003-01-21 | 2010-11-17 | 小野薬品工業株式会社 | 8−アザプロスタグランジン誘導体およびその医薬用途 |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| US6734206B1 (en) | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| US6734201B1 (en) | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents |
| GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| US20080306155A1 (en) * | 2004-09-16 | 2008-12-11 | Roman Richard J | Method for treating renal disease |
| US7893107B2 (en) * | 2005-11-30 | 2011-02-22 | Allergan, Inc. | Therapeutic methods using prostaglandin EP4 agonist components |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| WO2008073748A1 (en) | 2006-12-08 | 2008-06-19 | University Of Rochester | Expansion of hematopoietic stem cells |
| EP1952823A1 (de) * | 2007-01-30 | 2008-08-06 | AM-Pharma B.V. | Verwendung von alkalischer Phosphatase bei der Behandlung eingeschränkter Nierenfunktion |
| EP3533445A1 (de) | 2009-03-19 | 2019-09-04 | Fate Therapeutics, Inc. | Zusammensetzungen mit cyclischen amp-verstärkern und/oder ep-liganden sowie verfahren zu ihrer herstellung und verwendung |
| CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
| RU2711531C2 (ru) | 2010-06-17 | 2020-01-17 | Нитто Денко Корпорейшн | Средство для лечения фиброза почек |
| US20140030232A1 (en) | 2010-08-12 | 2014-01-30 | Fate Therapeutics, Inc. | Hematopoietic stem and progenitor cell therapy |
| EP2740475A4 (de) * | 2011-08-02 | 2015-02-25 | Ono Pharmaceutical Co | Wirkstoff zur verbesserung der linksventrikulären diastolischen funktion |
| AU2012315699B2 (en) | 2011-09-30 | 2017-08-17 | Bluebird Bio, Inc. | Compounds for improved viral transduction |
| ES2682255T3 (es) | 2011-12-02 | 2018-09-19 | Fate Therapeutics, Inc. | Métodos mejorados de tratamiento de isquemia |
| AU2012321088B8 (en) | 2011-12-02 | 2016-12-15 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| US20150272874A1 (en) | 2012-10-29 | 2015-10-01 | Cardio Incorporated | Pulmonary disease-specific therapeutic agent |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| EP2968416A4 (de) | 2013-03-15 | 2016-08-17 | Fate Therapeutics Inc | Zellpotenztest für therapeutisches potenzial |
| JP6449166B2 (ja) | 2013-10-15 | 2019-01-09 | 小野薬品工業株式会社 | 薬剤溶出性ステントグラフト |
| PT3461891T (pt) | 2014-01-24 | 2020-07-30 | Am Pharma Bv | Processamento a jusante de uma fosfatase alcalina |
| CN106164262B (zh) | 2014-01-24 | 2020-08-07 | 安-法玛公司 | 嵌合型碱性磷酸酶样蛋白 |
| US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
| JP2018504122A (ja) | 2015-01-26 | 2018-02-15 | フェイト セラピューティクス,インコーポレイテッド | 免疫調節特性が増加した細胞ならびにその使用および製造のための方法 |
| EP3307747A4 (de) | 2015-06-12 | 2019-02-27 | Simon Fraser University | Amid-verlinkte ep4-agonist-bisphosphonatverbindungen und verwendungen davon |
| KR20180033537A (ko) | 2015-07-21 | 2018-04-03 | 더 칠드런스 메디칼 센터 코포레이션 | Pd-l1 발현 조혈 줄기 세포 및 용도 |
| ES2992295T3 (es) | 2016-02-12 | 2024-12-11 | Bluebird Bio Inc | Composiciones potenciadoras de Vcn y métodos de uso de las mismas |
| WO2017139561A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| CN109072186B (zh) | 2016-03-04 | 2023-06-23 | 莱兰斯坦福初级大学评议会 | 利用前列腺素e2进行肌肉再生的组合物和方法 |
| CA3065945A1 (en) | 2017-06-09 | 2018-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for preventing or treating muscle conditions |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| EP4146797A1 (de) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Behandlung von neurodegenerativen erkrankungen |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066692A (en) | 1972-10-30 | 1978-01-03 | Merck & Co., Inc. | 11,12-secoprostaglandins |
| US3987091A (en) | 1973-04-12 | 1976-10-19 | Merck & Co., Inc. | 11,12-secoprostaglandins |
| US4033996A (en) | 1973-04-25 | 1977-07-05 | Merck & Co., Inc. | 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins |
| SE7414770L (de) | 1973-12-13 | 1975-06-16 | Merck & Co Inc | |
| US3991087A (en) | 1973-12-13 | 1976-11-09 | Merck & Co., Inc. | 8-Halo-11,12-secoprostaglandins |
| DK366475A (da) | 1974-08-30 | 1976-03-01 | Merck & Co Inc | Fremgangsmade til fremstilling af aryloxy- eller arylthioholdige secoprostaglandiner |
| US4055596A (en) | 1974-09-13 | 1977-10-25 | Merck & Co., Inc. | 11,12-Seco-prostaglandins |
| US3991106A (en) | 1974-09-13 | 1976-11-09 | Merck & Co., Inc. | 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins |
| CA1077948A (en) * | 1976-08-06 | 1980-05-20 | Albin J. Nelson | 1,-5 disubstituted-2-pyrrolidones and processes for their production |
| US4177346A (en) | 1976-08-06 | 1979-12-04 | Pfizer Inc. | 1,5-Disubstituted-2-pyrrolidones |
| US4175203A (en) | 1976-12-17 | 1979-11-20 | Merck & Co., Inc. | Interphenylene 11,12-secoprostaglandins |
| US4112236A (en) | 1977-04-04 | 1978-09-05 | Merck & Co., Inc. | Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins |
| US5605814A (en) | 1993-08-31 | 1997-02-25 | Merck Frosst Canada Inc. | DNA encoding human prostaglandin receptor EP2 |
| US5716835A (en) | 1994-05-05 | 1998-02-10 | Allergan, Inc. | Nucleic acid encoding a novel human EP prostaglandin receptor |
| US5807895A (en) * | 1994-11-29 | 1998-09-15 | Schwarz Pharma, Inc. | Use of prostaglandin E1, E2 or analogs to prevent renal failure induced by medical tests that utilize contrast media agents |
| UA59384C2 (uk) | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
| JPH10265454A (ja) | 1997-01-27 | 1998-10-06 | Ono Pharmaceut Co Ltd | 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
| WO1998058911A2 (en) | 1997-06-23 | 1998-12-30 | Pfizer Inc. | Prostaglandin agonists |
| SE9702681D0 (sv) | 1997-07-10 | 1997-07-10 | Pharmacia & Upjohn Ab | Method and composition for treatment of impotence |
| UA67754C2 (uk) | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
| US6124314A (en) | 1997-10-10 | 2000-09-26 | Pfizer Inc. | Osteoporosis compounds |
| TWI249520B (en) * | 1998-07-15 | 2006-02-21 | Ono Pharmaceutical Co | 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient |
| EP1114816A4 (de) * | 1998-09-14 | 2002-09-04 | Ono Pharmaceutical Co | $g(v)-SUBSTITUIERTE PHENYL-PROSTAGLANDIN-E-DERIVATE UND SIE ALS AKTIVEN BESTANDTEIL ENTHALTENDE MEDIKAMENTE |
| WO2000054808A1 (fr) * | 1999-03-16 | 2000-09-21 | Toray Industries, Inc. | Agoniste du recepteur ep4 de la prostaglandine et traitement correspondant |
-
2001
- 2001-01-25 DE DE60120007T patent/DE60120007T2/de not_active Expired - Fee Related
- 2001-01-25 PT PT01300690T patent/PT1132086E/pt unknown
- 2001-01-25 DK DK01300690T patent/DK1132086T3/da active
- 2001-01-25 ES ES01300690T patent/ES2263557T3/es not_active Expired - Lifetime
- 2001-01-25 EP EP01300690A patent/EP1132086B1/de not_active Expired - Lifetime
- 2001-01-25 AT AT01300690T patent/ATE327751T1/de not_active IP Right Cessation
- 2001-01-25 IL IL14112001A patent/IL141120A0/xx unknown
- 2001-01-29 CA CA002332687A patent/CA2332687A1/en not_active Abandoned
- 2001-01-29 US US09/771,164 patent/US6610719B2/en not_active Expired - Fee Related
- 2001-01-29 PE PE2001000097A patent/PE20011048A1/es not_active Application Discontinuation
- 2001-01-30 AU AU16722/01A patent/AU774569B2/en not_active Ceased
- 2001-01-30 JP JP2001021534A patent/JP3839261B2/ja not_active Expired - Fee Related
- 2001-01-30 ZA ZA200100827A patent/ZA200100827B/xx unknown
- 2001-01-30 NZ NZ509632A patent/NZ509632A/xx unknown
- 2001-01-30 HU HU0100495A patent/HUP0100495A3/hu unknown
- 2001-01-31 KR KR10-2001-0004590A patent/KR100419684B1/ko not_active Expired - Fee Related
- 2001-01-31 CO CO01007013A patent/CO5261529A1/es not_active Application Discontinuation
-
2006
- 2006-02-24 JP JP2006047746A patent/JP2006182788A/ja active Pending
- 2006-07-04 CY CY20061100920T patent/CY1105299T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1672201A (en) | 2001-08-02 |
| HUP0100495A3 (en) | 2003-12-29 |
| CA2332687A1 (en) | 2001-07-31 |
| NZ509632A (en) | 2003-01-31 |
| JP2006182788A (ja) | 2006-07-13 |
| EP1132086B1 (de) | 2006-05-31 |
| JP2001233792A (ja) | 2001-08-28 |
| US20010041729A1 (en) | 2001-11-15 |
| ES2263557T3 (es) | 2006-12-16 |
| US6610719B2 (en) | 2003-08-26 |
| DE60120007D1 (de) | 2006-07-06 |
| CY1105299T1 (el) | 2010-03-03 |
| IL141120A0 (en) | 2002-02-10 |
| KR20010078209A (ko) | 2001-08-20 |
| EP1132086A2 (de) | 2001-09-12 |
| EP1132086A3 (de) | 2002-01-09 |
| ZA200100827B (en) | 2002-07-30 |
| HUP0100495A2 (en) | 2002-10-28 |
| KR100419684B1 (ko) | 2004-02-21 |
| HU0100495D0 (en) | 2001-03-28 |
| JP3839261B2 (ja) | 2006-11-01 |
| DK1132086T3 (da) | 2006-08-28 |
| AU774569B2 (en) | 2004-07-01 |
| DE60120007T2 (de) | 2006-11-16 |
| PE20011048A1 (es) | 2001-10-19 |
| PT1132086E (pt) | 2006-09-29 |
| CO5261529A1 (es) | 2003-03-31 |
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