AR051485A1 - Pirazolo pirimidinas 1,4-sustituidas como inhibidores de quinasa - Google Patents

Pirazolo pirimidinas 1,4-sustituidas como inhibidores de quinasa

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Publication number
AR051485A1
AR051485A1 ARP050104725A ARP050104725A AR051485A1 AR 051485 A1 AR051485 A1 AR 051485A1 AR P050104725 A ARP050104725 A AR P050104725A AR P050104725 A ARP050104725 A AR P050104725A AR 051485 A1 AR051485 A1 AR 051485A1
Authority
AR
Argentina
Prior art keywords
unsubstituted
methyl
pirimidinas
pirazolo
replaced
Prior art date
Application number
ARP050104725A
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English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR051485A1 publication Critical patent/AR051485A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P37/02—Immunomodulators
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Reivindicacion 1: Un compuesto de la formula (1) en donde R1 es una fraccion de la formula (2) en donde Ra es metilo, etilo, metoxilo, halogeno, o trifluoro-metilo; Re es H, metilo, etilo, metoxilo, halogeno, o trifluoro-metilo, y Rb, Rc, y Rd se seleccionan independientemente a partir de los sustituyentes de H y fenilo; R2 es arilo insustituido o sustituido; R3 es H, alquilo insustituido o sustituido, arilo insustituido o sustituido, o heterociclo insustituido o sustituido; y R4 es H o alquilo insustituido o sustituido; o una sal farmacéuticamente aceptable del mismo, en donde estén presentes uno o más grupos formadores de sales, para utilizarse en el diagnostico o en el tratamiento terapéutico de un animal de sangre caliente.
ARP050104725A 2004-11-12 2005-11-11 Pirazolo pirimidinas 1,4-sustituidas como inhibidores de quinasa AR051485A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0425035A GB0425035D0 (en) 2004-11-12 2004-11-12 Organic compounds

Publications (1)

Publication Number Publication Date
AR051485A1 true AR051485A1 (es) 2007-01-17

Family

ID=33523649

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104725A AR051485A1 (es) 2004-11-12 2005-11-11 Pirazolo pirimidinas 1,4-sustituidas como inhibidores de quinasa

Country Status (15)

Country Link
US (1) US20080096868A1 (es)
EP (1) EP1812441A1 (es)
JP (1) JP2008519790A (es)
KR (1) KR20070084191A (es)
CN (1) CN101098873A (es)
AR (1) AR051485A1 (es)
AU (1) AU2005303965A1 (es)
BR (1) BRPI0517803A (es)
CA (1) CA2585660A1 (es)
GB (1) GB0425035D0 (es)
GT (1) GT200500325A (es)
MX (1) MX2007005644A (es)
RU (1) RU2007121846A (es)
TW (1) TW200621783A (es)
WO (1) WO2006050946A1 (es)

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