AR045113A1 - Derivados sustituidos del dioxido de tiazolbenzoisotiazol, procedimiento para su preparacion y su uso - Google Patents
Derivados sustituidos del dioxido de tiazolbenzoisotiazol, procedimiento para su preparacion y su usoInfo
- Publication number
- AR045113A1 AR045113A1 ARP040102644A ARP040102644A AR045113A1 AR 045113 A1 AR045113 A1 AR 045113A1 AR P040102644 A ARP040102644 A AR P040102644A AR P040102644 A ARP040102644 A AR P040102644A AR 045113 A1 AR045113 A1 AR 045113A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- cooh
- coo
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a compuestos de derivados sustituidos del dióxido de tiazol-benzoisotiazol, y a sus sales fisiológicamente aceptables, que son adecuados como medicamentos para producir la glucosa en sangre y para la prevención y el tratamiento de la diabetes. También se refiere al procedimiento para su preparación. Reivindicación 1: Un compuesto de la fórmula (1) en la que los significados son R1, R2 independientemente entre sí, H, arilo, COOH, alquilen(C1-6)-COOH, -COO-alquilo (C1-6), alquilen(C1-6)-COO-alquilo (C1-6), alquilo (C1-6), alquenilo (C2-6), alquilen (C1-6)-arilo, heterociclo, alquilen (C1-6)-heterociclo, CF3, OCF3, CN, (CH2)1-6-OH, O-alquilo (C1-6), CO-alquilo (C1-6), -C(O)O-alquilo, COOH,, CON(R9)(R10), en donde los radicales arilo y los radicales heterociclo pueden estar sustituidos una o más veces con F, Cl, Br, (CH2)0-2-OH, alquilo (C1-6), alquenilo (C2-6), alquinilo (C2-6), CF3, OCF3, N(R9)(R10), piperidinona, piperazina, piperazinona, N-(alquilen-(C1-6)-piperazina, N-(alquilen (C1-6))-piperazinona, morfolina, tiomorfolina, NO2, CN, O-alquilo (C1-6), S(O)0-2-alquilo(C1-6). SO2-N(R9(R10), CO-alquilo (C1-6), -COOH, alquilen (C1-6)-COOH, COO-alquilo (C1-6), alquilen (C1-6)-COO-alquilo (C1-6), cicloalquilo (C3-10), fenilo, en donde estas piperidinona, piperazina, piperazinona, N-alquilen (C1-6-piperazina, N-(alquilen (C1-6)-piperazinona, morfolina, tiomorfolina y anillos fenilo pueden estar sustituidos una o más veces con F, Cl, Br, (CH2)0-2-OH, COOH, CN, NO2, -O-alquilo (C1-6), -NH-O-alquilo(C1-6), -(CO)-NH-O-alquilen (C1-6)-N-(R9)(R10), -(CO)-alquilo (C1-6), -alquilo (C1-6), CF3, OCF3, N(R9)(R10); R3 H, alquilo (C1-6), alquilen (C1-6)-arilo, -C(O)-arilo, alquilen (C1-6)-heterociclo, CO-alquilo (C1-6), en donde los radicales arilo y heterociclo pueden estar sustituidos una i más veces con F, Cl, Br, alquilo (C1-6), COOH, COO-alquilo(C1-6), CF3 u OCF3; R4, R5 independientemente entre sí: H, F, Cl, Br, alquilo(C1-6), CF3, OCF3, NO2, N(R9)(R10), CN, O-alquilo-(C1-6), CO-alquilo(C1-6), COOH, alquilen(C1-6)-COOH, CON(R9)(R10), alquilen(C1-6)-CON(R9)(R10), COO-alquilo(C1-6), alquilen(C1-6)-COO-alquilo (C1-6), S(O)0-2-alquilo (C1-6), S(O)2-N(R9)(R10), CH2OH, CH2OCH3; R6, R7 independientemente entre sí, H, F, CL, Br, alquilo (C1-6), ciclopropilo, tetrafluoro-ciclopropilo, difluoro-ciclopropilo, o R6 y R7 forman, juntos, el grupo =CH2; R8 H, CH3, CF3, CH2OH; R9 H, alquilo(C1-4); R10 H, alquilo(C1-4); o R9 y R10 forman, junto con el átomo N al que están unidos, un sistema de anillo de 3-9 miembros; y sus sales fisiológicamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10334309A DE10334309A1 (de) | 2003-07-28 | 2003-07-28 | Substituierte Thiazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045113A1 true AR045113A1 (es) | 2005-10-19 |
Family
ID=34111694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102644A AR045113A1 (es) | 2003-07-28 | 2004-07-26 | Derivados sustituidos del dioxido de tiazolbenzoisotiazol, procedimiento para su preparacion y su uso |
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP1651644B1 (es) |
| JP (1) | JP2007500145A (es) |
| KR (1) | KR20060052886A (es) |
| CN (1) | CN100413862C (es) |
| AR (1) | AR045113A1 (es) |
| AT (1) | ATE346065T1 (es) |
| AU (1) | AU2004261370B2 (es) |
| BR (1) | BRPI0412997A (es) |
| CA (1) | CA2533673A1 (es) |
| CR (1) | CR8202A (es) |
| CY (1) | CY1105962T1 (es) |
| DE (2) | DE10334309A1 (es) |
| DK (1) | DK1651644T3 (es) |
| EC (1) | ECSP066326A (es) |
| ES (1) | ES2276319T3 (es) |
| GT (1) | GT200400146A (es) |
| HK (1) | HK1091825A1 (es) |
| IL (1) | IL173289A0 (es) |
| JO (1) | JO2449B1 (es) |
| MA (1) | MA27932A1 (es) |
| MY (1) | MY141197A (es) |
| NO (1) | NO20060908L (es) |
| NZ (1) | NZ544975A (es) |
| OA (1) | OA13198A (es) |
| PA (1) | PA8607201A1 (es) |
| PE (1) | PE20050326A1 (es) |
| PL (1) | PL1651644T3 (es) |
| PT (1) | PT1651644E (es) |
| RS (1) | RS20060015A (es) |
| RU (1) | RU2350613C2 (es) |
| SA (1) | SA04250332B1 (es) |
| SI (1) | SI1651644T1 (es) |
| TN (1) | TNSN06030A1 (es) |
| TW (1) | TW200524923A (es) |
| UA (1) | UA83057C2 (es) |
| UY (1) | UY28443A1 (es) |
| WO (1) | WO2005012295A1 (es) |
| ZA (1) | ZA200510378B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004026532A1 (de) * | 2004-05-29 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Oxazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| DK2402317T3 (da) | 2006-03-31 | 2013-10-07 | Novartis Ag | DGAT-inhibitor |
| EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| CN102482312A (zh) | 2009-08-26 | 2012-05-30 | 赛诺菲 | 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539584A (en) * | 1967-11-14 | 1970-11-10 | Colgate Palmolive Co | 5-substituted-2,1-benzisothiazolines |
| JPH04128276A (ja) * | 1990-09-19 | 1992-04-28 | Pfizer Pharmaceut Co Ltd | アミノベンゾサルタム誘導体およびその用途 |
| CO5190696A1 (es) * | 1999-06-16 | 2002-08-29 | Smithkline Beecham Corp | Antagonistas de los receptores il-8 |
| DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
-
2003
- 2003-07-28 DE DE10334309A patent/DE10334309A1/de not_active Withdrawn
-
2004
- 2004-06-14 JO JO200481A patent/JO2449B1/en active
- 2004-07-13 PE PE2004000664A patent/PE20050326A1/es not_active Application Discontinuation
- 2004-07-15 BR BRPI0412997-0A patent/BRPI0412997A/pt not_active IP Right Cessation
- 2004-07-15 WO PCT/EP2004/007847 patent/WO2005012295A1/de active IP Right Grant
- 2004-07-15 KR KR1020067001721A patent/KR20060052886A/ko not_active Application Discontinuation
- 2004-07-15 DK DK04741034T patent/DK1651644T3/da active
- 2004-07-15 ES ES04741034T patent/ES2276319T3/es not_active Expired - Lifetime
- 2004-07-15 RS YUP-2006/0015A patent/RS20060015A/sr unknown
- 2004-07-15 CN CNB2004800220877A patent/CN100413862C/zh not_active Expired - Fee Related
- 2004-07-15 JP JP2006521446A patent/JP2007500145A/ja not_active Abandoned
- 2004-07-15 PA PA20048607201A patent/PA8607201A1/es unknown
- 2004-07-15 PT PT04741034T patent/PT1651644E/pt unknown
- 2004-07-15 AU AU2004261370A patent/AU2004261370B2/en not_active Ceased
- 2004-07-15 CA CA002533673A patent/CA2533673A1/en not_active Abandoned
- 2004-07-15 EP EP04741034A patent/EP1651644B1/de not_active Expired - Lifetime
- 2004-07-15 UA UAA200602134A patent/UA83057C2/ru unknown
- 2004-07-15 OA OA1200600026A patent/OA13198A/en unknown
- 2004-07-15 DE DE502004002117T patent/DE502004002117D1/de not_active Expired - Lifetime
- 2004-07-15 NZ NZ544975A patent/NZ544975A/en unknown
- 2004-07-15 PL PL04741034T patent/PL1651644T3/pl unknown
- 2004-07-15 RU RU2006106231/04A patent/RU2350613C2/ru not_active IP Right Cessation
- 2004-07-15 AT AT04741034T patent/ATE346065T1/de not_active IP Right Cessation
- 2004-07-15 SI SI200430126T patent/SI1651644T1/sl unknown
- 2004-07-23 GT GT200400146A patent/GT200400146A/es unknown
- 2004-07-26 TW TW093122232A patent/TW200524923A/zh unknown
- 2004-07-26 AR ARP040102644A patent/AR045113A1/es not_active Application Discontinuation
- 2004-07-27 MY MYPI20043005A patent/MY141197A/en unknown
- 2004-07-28 UY UY28443A patent/UY28443A1/es unknown
- 2004-10-11 SA SA04250332A patent/SA04250332B1/ar unknown
-
2005
- 2005-12-21 ZA ZA200510378A patent/ZA200510378B/xx unknown
-
2006
- 2006-01-18 CR CR8202A patent/CR8202A/es not_active Application Discontinuation
- 2006-01-22 IL IL173289A patent/IL173289A0/en unknown
- 2006-01-26 MA MA28753A patent/MA27932A1/fr unknown
- 2006-01-26 EC EC2006006326A patent/ECSP066326A/es unknown
- 2006-01-27 TN TNP2006000030A patent/TNSN06030A1/en unknown
- 2006-02-24 NO NO20060908A patent/NO20060908L/no not_active Application Discontinuation
- 2006-11-10 HK HK06112382A patent/HK1091825A1/xx not_active IP Right Cessation
-
2007
- 2007-01-29 CY CY20071100112T patent/CY1105962T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |