AR048195A1 - Uso de un derivado de fenotiazina para la prevencion y/o tratamiento de la perdida de audicion - Google Patents
Uso de un derivado de fenotiazina para la prevencion y/o tratamiento de la perdida de audicionInfo
- Publication number
- AR048195A1 AR048195A1 ARP050101212A ARP050101212A AR048195A1 AR 048195 A1 AR048195 A1 AR 048195A1 AR P050101212 A ARP050101212 A AR P050101212A AR P050101212 A ARP050101212 A AR P050101212A AR 048195 A1 AR048195 A1 AR 048195A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hearing loss
- atom
- prevention
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B21/00—Thiazine dyes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: El uso de un derivado heterocíclico correspondiente a la formula (1) bajo la forma de un diastereoisomero o de cualquier combinacion de éstas formas, donde R representa un átomo de H, un radical alquilo C1-6, arilalquilo o -C(O)R', donde R' representa un radical heterocicloalquilo, alquilo C1-6, arilo o aralquilo; donde los radicales alquilo, arilo o heterocicloalquilo están opcionalmente sustituidos por uno o más sustituyentes idénticos o diferentes seleccionados entre alquilo C1-6, hidroxilo, alcoxilo C1-6, nitro, ciano, halogeno o NR1R2; R1 y R2 representan independientemente un átomo de H o un radical alquilo C1-6, o R1 y R2, junto con el átomo de N al que están unidos, forman un heterociclo opcionalmente sustituido, caracterizado porque es para la preparacion de un medicamento dirigido a la prevencion y/o el tratamiento de la pérdida de audicion. Reivindicacion 22: Un producto caracterizado porque comprende un derivado heterocíclico de formula (1), como se define en una de las reivindicaciones 1 a 9, y al menos una sustancia con actividad terapéutica, como un producto de combinacion para un uso que es simultáneo, separado o extendido en el tiempo, para prevenir y/o tratar la pérdida de audicion
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0403203A FR2867979B1 (fr) | 2004-03-29 | 2004-03-29 | Nouvelle application therapeutique d'un derive de la phenothiazine |
| FR0406404 | 2004-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048195A1 true AR048195A1 (es) | 2006-04-05 |
Family
ID=34968214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101212A AR048195A1 (es) | 2004-03-29 | 2005-03-30 | Uso de un derivado de fenotiazina para la prevencion y/o tratamiento de la perdida de audicion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7696197B2 (es) |
| EP (1) | EP1732567B1 (es) |
| JP (1) | JP5066444B2 (es) |
| AR (1) | AR048195A1 (es) |
| AT (1) | ATE410169T1 (es) |
| CA (1) | CA2560988A1 (es) |
| DE (1) | DE602005010222D1 (es) |
| DK (1) | DK1732567T3 (es) |
| ES (1) | ES2315868T3 (es) |
| HK (1) | HK1101545A1 (es) |
| PL (1) | PL1732567T3 (es) |
| PT (1) | PT1732567E (es) |
| RU (1) | RU2377992C2 (es) |
| WO (1) | WO2005092345A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007045761A1 (fr) * | 2005-10-21 | 2007-04-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derives d'amidine et leurs applications a titre de medicament |
| FR2892415B1 (fr) * | 2005-10-21 | 2007-11-30 | Sod Conseils Rech Applic | Derives d'amidine et leurs applications a titre de medicament |
| FR2898274B1 (fr) * | 2006-03-07 | 2008-10-03 | Sod Conseils Rech Applic | Composition contenant des derives d'amidine ou de carboxamide et des steroides a titre de medicament |
| EP2428230A1 (en) * | 2008-12-25 | 2012-03-14 | Canon Kabushiki Kaisha | Probe for auditory hair cells. |
| GB2467561A (en) * | 2009-02-06 | 2010-08-11 | Summit Corp Plc | Dual calpain-ROS inhibitors |
| US20150150843A1 (en) * | 2012-05-21 | 2015-06-04 | Randall T. Peterson | Cardioprotective compounds, their use with chemotherapy, and methods for identifying them |
| EP2970311A4 (en) | 2013-03-14 | 2016-11-23 | Brigham & Womens Hospital | BMP INHIBITORS AND METHODS OF USE |
| RU2529700C1 (ru) * | 2013-04-12 | 2014-09-27 | Закрытое Акционерное Общество "Клинский институт охраны и условий труда "ОЛС-Комплект" | Способ профилактики профессиональной потери слуха |
| US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
| US20180161459A1 (en) * | 2014-08-29 | 2018-06-14 | Sound Pharmaceuticals Incorporated | Methods of Screening for Drugs to Prevent Noise-Induced Hearing Loss |
| JP6999896B2 (ja) | 2017-09-21 | 2022-01-19 | 学校法人慶應義塾 | 音響外傷難聴モデル動物の作製方法及びそれにより作製される音響外傷難聴モデル動物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2389685C (fr) * | 1999-11-05 | 2011-07-12 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R) | Nouveaux composes heterocycliques et leur application a titre de medicaments |
| FR2816509B1 (fr) * | 2000-11-15 | 2004-02-06 | Sod Conseils Rech Applic | Association d'inhibiteurs de calpaine et de piegeurs des formes reactives de l'oxygene |
| FR2863268B1 (fr) | 2003-12-09 | 2006-02-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments |
-
2005
- 2005-03-25 JP JP2007505576A patent/JP5066444B2/ja not_active Expired - Fee Related
- 2005-03-25 DK DK05744629T patent/DK1732567T3/da active
- 2005-03-25 ES ES05744629T patent/ES2315868T3/es active Active
- 2005-03-25 EP EP05744629A patent/EP1732567B1/fr not_active Not-in-force
- 2005-03-25 RU RU2006138035/15A patent/RU2377992C2/ru not_active IP Right Cessation
- 2005-03-25 PT PT05744629T patent/PT1732567E/pt unknown
- 2005-03-25 WO PCT/FR2005/000713 patent/WO2005092345A1/fr active Application Filing
- 2005-03-25 US US10/594,960 patent/US7696197B2/en not_active Expired - Fee Related
- 2005-03-25 CA CA002560988A patent/CA2560988A1/fr not_active Abandoned
- 2005-03-25 AT AT05744629T patent/ATE410169T1/de active
- 2005-03-25 DE DE602005010222T patent/DE602005010222D1/de active Active
- 2005-03-25 PL PL05744629T patent/PL1732567T3/pl unknown
- 2005-03-30 AR ARP050101212A patent/AR048195A1/es not_active Application Discontinuation
-
2007
- 2007-06-12 HK HK07106266.7A patent/HK1101545A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2560988A1 (fr) | 2005-10-06 |
| RU2006138035A (ru) | 2008-05-10 |
| US7696197B2 (en) | 2010-04-13 |
| DK1732567T3 (da) | 2009-02-09 |
| RU2377992C2 (ru) | 2010-01-10 |
| US20080275034A1 (en) | 2008-11-06 |
| ES2315868T3 (es) | 2009-04-01 |
| PT1732567E (pt) | 2009-01-14 |
| DE602005010222D1 (de) | 2008-11-20 |
| ATE410169T1 (de) | 2008-10-15 |
| EP1732567B1 (fr) | 2008-10-08 |
| PL1732567T3 (pl) | 2009-04-30 |
| EP1732567A1 (fr) | 2006-12-20 |
| JP5066444B2 (ja) | 2012-11-07 |
| HK1101545A1 (en) | 2007-10-18 |
| JP2007530640A (ja) | 2007-11-01 |
| WO2005092345A1 (fr) | 2005-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |