OA11277A - 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists. - Google Patents

4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists. Download PDF

Info

Publication number
OA11277A
OA11277A OA1200000007A OA1200000007A OA11277A OA 11277 A OA11277 A OA 11277A OA 1200000007 A OA1200000007 A OA 1200000007A OA 1200000007 A OA1200000007 A OA 1200000007A OA 11277 A OA11277 A OA 11277A
Authority
OA
OAPI
Prior art keywords
alkyl
methyl
phenyl
imidazo
pyridine
Prior art date
Application number
OA1200000007A
Other languages
English (en)
Inventor
Robert Lee Dow
Marlys Hammond
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11277A publication Critical patent/OA11277A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
OA1200000007A 1997-08-05 2000-01-14 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists. OA11277A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5473497P 1997-08-05 1997-08-05

Publications (1)

Publication Number Publication Date
OA11277A true OA11277A (en) 2003-07-29

Family

ID=21993163

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000007A OA11277A (en) 1997-08-05 2000-01-14 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists.

Country Status (32)

Country Link
US (1) US6187778B1 (de)
EP (1) EP1003744B1 (de)
JP (1) JP3711238B2 (de)
KR (1) KR20010022583A (de)
CN (1) CN1264381A (de)
AP (1) AP9801312A0 (de)
AT (1) ATE296825T1 (de)
AU (1) AU7927498A (de)
BG (1) BG104107A (de)
BR (1) BR9811844A (de)
CA (1) CA2293621C (de)
CO (1) CO4960634A1 (de)
DE (1) DE69830409T2 (de)
EA (1) EA200000098A1 (de)
ES (1) ES2241146T3 (de)
GT (1) GT199800114A (de)
HR (1) HRP980434A2 (de)
HU (1) HUP0002956A3 (de)
ID (1) ID24300A (de)
IL (1) IL133430A0 (de)
IS (1) IS5294A (de)
MA (1) MA24629A1 (de)
NO (1) NO996178L (de)
OA (1) OA11277A (de)
PA (1) PA8456601A1 (de)
PE (1) PE106199A1 (de)
PL (1) PL338575A1 (de)
SA (1) SA98190435A (de)
TN (1) TNSN98148A1 (de)
TR (1) TR200000333T2 (de)
WO (1) WO1999007703A1 (de)
ZA (1) ZA986968B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
EA200200421A1 (ru) * 1999-09-30 2002-10-31 Ньюроджен Корпорейшн АМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-a]-1,3,5-ТРИАЗИНЫ
CN100379734C (zh) * 1999-12-24 2008-04-09 阿文蒂斯药物有限公司 氮杂吲哚类化合物
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
GEP20105024B (en) 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound
JP2008503469A (ja) 2004-06-17 2008-02-07 ワイス ゴナドトロピン放出ホルモン受容体アンタゴニスト
RU2007101509A (ru) 2004-06-17 2008-07-27 Уайт (Us) Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин
AR050365A1 (es) * 2004-08-02 2006-10-18 Osi Pharm Inc Compuestos inhibidores de multi- quinasa pirrolopirimidina aril- amino sustituidos.
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
KR20060087386A (ko) * 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
WO2006080821A1 (en) * 2005-01-28 2006-08-03 Daewoong Pharmaceutical Co., Ltd. Novel benzoimidazole derivatives and pharmaceutical composition comprising the same
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US20090213731A1 (en) * 2005-04-15 2009-08-27 Regenertech Pty Limited Use of neuropeptide y (npy) and agonists and antagonists thereof for tissue regeneration
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
WO2007007910A1 (ja) * 2005-07-13 2007-01-18 Banyu Pharmaceutical Co., Ltd. ヘテロ環置換ベンズイミダゾール誘導体
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
AR057525A1 (es) * 2005-10-03 2007-12-05 Astrazeneca Ab Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
EP1963320A1 (de) * 2005-12-07 2008-09-03 OSI Pharmaceuticals, Inc. Pyrrolopyridinkinasehemmende verbindungen
WO2007072017A2 (en) * 2005-12-22 2007-06-28 The Institute Of Cancer Research Enzyme inhibitors
KR20080085232A (ko) 2006-02-17 2008-09-23 화이자 리미티드 Ｔｌｒ7 조절제로서 3-데아자퓨린 유도체
DK3421471T3 (da) 2006-04-25 2021-06-14 Astex Therapeutics Ltd Purin- og deazapurinderivater som farmaceutiske forbindelser
CA2656810C (en) 2006-07-11 2012-03-13 Daewoong Pharmaceutical Co., Ltd. Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
KR101134239B1 (ko) 2006-07-11 2012-04-10 주식회사 대웅제약 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
WO2008121064A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
SI2201012T1 (sl) 2007-10-11 2014-10-30 Astrazeneca Ab Derivati pirolo(2,3-D)pirimidina kot inhibitorji proteina kinaze B
AU2009211004C1 (en) 2008-01-11 2013-08-01 Natco Pharma Limited Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
DK2694056T3 (da) 2011-04-01 2020-01-02 Astrazeneca Ab Terapeutisk behandling
MY175800A (en) 2011-11-30 2020-07-09 Astrazeneca Ab Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274213A (en) 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
DE2818676A1 (de) * 1978-04-27 1979-11-08 Troponwerke Gmbh & Co Kg Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9022644D0 (en) * 1990-10-18 1990-11-28 Ici Plc Heterocyclic compounds
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5284971A (en) 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
ES2108855T3 (es) 1992-07-21 1998-01-01 Ciba Geigy Ag Derivados de acido oxamico como agentes hipocolesteremicos.
ES2109796T3 (es) * 1994-05-03 1998-01-16 Ciba Geigy Ag Derivados de pirrolopirimidilo con efecto antiproliferante.
NZ293249A (en) * 1994-09-29 1999-04-29 Novartis Ag 4-amino-5,7-diaryl-pyrrolo[2,3-d]pyrimidines and their use
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
BR9509610A (pt) 1994-11-07 1997-10-28 Pfizer Ligandos específicos de neuropeptideo Y1
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
EP0759441A3 (de) 1995-06-30 1999-06-30 Eli Lilly And Company Verfahren zur Behandlung von mit Neuropeptid Y assozierten Zuständen
JP2000501107A (ja) * 1996-01-09 2000-02-02 イーライ・リリー・アンド・カンパニー ベンズイミダゾリル神経ペプチドｙ受容体アンタゴニスト

Also Published As

Publication number Publication date
CA2293621C (en) 2003-12-30
AP9801312A0 (en) 2000-01-30
TR200000333T2 (tr) 2000-05-22
PA8456601A1 (es) 2000-05-24
AU7927498A (en) 1999-03-01
DE69830409D1 (de) 2005-07-07
EA200000098A1 (ru) 2000-08-28
GT199800114A (es) 2000-01-18
CO4960634A1 (es) 2000-09-25
KR20010022583A (ko) 2001-03-26
IL133430A0 (en) 2001-04-30
ID24300A (id) 2000-07-13
IS5294A (is) 1999-12-10
HUP0002956A2 (hu) 2001-08-28
EP1003744B1 (de) 2005-06-01
BG104107A (bg) 2000-08-31
CN1264381A (zh) 2000-08-23
ZA986968B (en) 2000-02-04
MA24629A1 (fr) 1999-04-01
PE106199A1 (es) 1999-11-02
SA98190435A (ar) 2005-12-03
TNSN98148A1 (fr) 2005-03-15
BR9811844A (pt) 2000-08-08
HUP0002956A3 (en) 2002-01-28
ATE296825T1 (de) 2005-06-15
JP2001512729A (ja) 2001-08-28
NO996178D0 (no) 1999-12-14
DE69830409T2 (de) 2006-01-26
JP3711238B2 (ja) 2005-11-02
WO1999007703A1 (en) 1999-02-18
PL338575A1 (en) 2000-11-06
CA2293621A1 (en) 1999-02-18
HRP980434A2 (en) 1999-04-30
ES2241146T3 (es) 2005-10-16
NO996178L (no) 2000-02-14
EP1003744A1 (de) 2000-05-31
US6187778B1 (en) 2001-02-13

Similar Documents

Publication Publication Date Title
OA11277A (en) 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists.
US6337332B1 (en) Neuropeptide Y receptor antagonists
EP0923581B1 (de) 4-substituierte beta-carboline als immunomodulatoren
US20070275990A1 (en) Heterocyclic Spiro Compound
US20080249154A1 (en) Preventive and/or Therapeutic Agent For Disease In Which Mitochondrial Benzodiazephine Receptor Participates
DE10233817A1 (de) Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2007521328A (ja) アンドロゲン受容体モジュレーター
DE19756036A1 (de) Amid- und Harnstoffderivate
US8748422B2 (en) Pharmaceutical compositions containing quinazoline derivatives for treating as serotonin receptor antagonist
US6407120B1 (en) Neuropeptide Y antagonists
AU726676B2 (en) 4-aminopyrrole (3,2-d) pyrimidines as Neuropeptide Y Receptor Antagonists
CA2299013C (en) Neuropeptide y antagonists
US20190175554A1 (en) Method for treating pruritus and/or itch
Cannon et al. 6-Hydroxy-4-[2-di-n-propylaminoethyl] indole: synthesis and dopaminergic actions
US20020058671A1 (en) Neuropeptide Y antagonists
EP1027891B1 (de) Neuropeptid Y Antagonisten
US20080312253A1 (en) Pharmaceutical compositions containing pyrazole derivatives for treating as serotonin antagonist
CZ439199A3 (cs) 4-Aminopyrrol(3^-d)pyrimidiny jako antagonisty receptoru neuropeptidu Y
MXPA99012095A (es) 4-aminopirrol (3,2-d) pirimidinas como antagonistas del receptor del neuropeptido y
AU2011376747A1 (en) Indanyl-substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them
MXPA00001707A (en) Amide derivatives useful as neuropeptide y (npy) antagonists
JP4555685B2 (ja) 肥満およびｃｎｓ障害の処置のための選択的ｄ１／ｄ５レセプターアンタゴニスト
JP2006501244A5 (de)