CO5680407A2 - Inhibidores novedosos de cinasas - Google Patents
Inhibidores novedosos de cinasasInfo
- Publication number
- CO5680407A2 CO5680407A2 CO05003967A CO05003967A CO5680407A2 CO 5680407 A2 CO5680407 A2 CO 5680407A2 CO 05003967 A CO05003967 A CO 05003967A CO 05003967 A CO05003967 A CO 05003967A CO 5680407 A2 CO5680407 A2 CO 5680407A2
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- heterocycle
- alkyl
- aryl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
1.- Compuesto de fórmula (I) caracterizado porque Z se selecciona del grupo que consiste de O, S, N, OH, y Cl, con la condición que cuando Z es O u S, R41 está ausente, y cuando Z es OH o Cl, ambos R41 y R42 están ausentes, y cuando Z es N, entonces R41 es H;X e Y son independientemente seleccionados delgrupo que consiste de O, OCO, S, SO, SO2, CO, CO2, NR10, NR11CO, NR12CONR13, NR14CO2, NR15SO2, NR16SO2NR17, SO2NR18, CONR19, halógeno, nitro y ciano, o X o Y están ausentes;R1 es hidrógeno, -CH3, OH, OCH3, SH, SCH3, OCOR21, SOR22, SO2R23, SO2NR24R25, CO2R26, CONR27R28, NH2, NR29SO2NR30R31, NR32SO2R33, NR34COR35, NR36CO2R37, NR38CONR39R40, halógeno, nitro, o ciano;R2 y R3 son independientemente hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, arilo, arilo sustituido, heterociclo, heterociclo sustituido, aralquilo, aralquilo sustituido, heteroarilo, heteroarilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido; con la condición que cuando X es halo, nitro o ciano, R2 está ausente, y, cuando Y es halo, nitro o ciano, R3 está ausente;R6 e s H, alquilo, alquilo sustituido, arilo, arilo sustituido, heterociclo, heterociclo sustituido, NR7R8, OR9 o halógeno;R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R21, R24, R25, R26, R27, R28, R29, R30, R31, R32, R34, R35, R36, R38, R39 y R40 son independientemente seleccionados del grupo que consiste de hidrógeno, alquilo, alquilo sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, o heterociclo sustituido;R22, R23, R33 y R37 son independientemente seleccionados del grupo que consiste de alquilo, alquilo sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, o heterociclo sustituido; ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39725602P | 2002-07-19 | 2002-07-19 | |
| US44721303P | 2003-02-13 | 2003-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5680407A2 true CO5680407A2 (es) | 2006-09-29 |
Family
ID=30773005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05003967A CO5680407A2 (es) | 2002-07-19 | 2005-01-19 | Inhibidores novedosos de cinasas |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US6869952B2 (es) |
| EP (3) | EP2280012A3 (es) |
| JP (2) | JP4361485B2 (es) |
| KR (1) | KR100901939B1 (es) |
| CN (3) | CN101880283B (es) |
| AR (1) | AR040500A1 (es) |
| AT (2) | ATE537843T1 (es) |
| AU (2) | AU2003254017A1 (es) |
| BR (2) | BR0312801A (es) |
| CA (2) | CA2492804C (es) |
| CO (1) | CO5680407A2 (es) |
| CY (1) | CY1112628T1 (es) |
| DE (1) | DE60336732D1 (es) |
| DK (1) | DK1534290T3 (es) |
| ES (1) | ES2377963T3 (es) |
| GE (2) | GEP20074124B (es) |
| HK (1) | HK1072545A1 (es) |
| HR (2) | HRP20050059B8 (es) |
| IL (3) | IL166129A0 (es) |
| IS (2) | IS7646A (es) |
| MX (2) | MXPA05000716A (es) |
| MY (1) | MY134848A (es) |
| NO (2) | NO330132B1 (es) |
| NZ (1) | NZ537523A (es) |
| PE (1) | PE20040680A1 (es) |
| PL (2) | PL375352A1 (es) |
| PT (1) | PT1534290E (es) |
| RS (2) | RS20050041A (es) |
| RU (2) | RU2005104818A (es) |
| SI (1) | SI1534290T1 (es) |
| TW (1) | TWI329112B (es) |
| UA (1) | UA82846C2 (es) |
| WO (2) | WO2004009601A1 (es) |
Families Citing this family (198)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1386922B1 (en) * | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| DE69734871D1 (de) * | 1997-05-30 | 2006-01-19 | St Microelectronics Srl | Verfahren zur Herstellung eines Germanium-implantierten bipolaren Heteroübergangtransistors |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
| US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
| ES2318122T3 (es) | 2002-04-23 | 2009-05-01 | Bristol-Myers Squibb Company | Compuestos de aril cetona pirrolo-triazina utiles como inhibidores de quinasa. |
| WO2003090912A1 (en) * | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Pyrrolo-triazine aniline compounds useful as kinase inhibitors |
| TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
| TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| MXPA05002113A (es) * | 2002-08-23 | 2005-06-03 | Sloan Kettering Inst Cancer | Sintesis de epotilonas, intermediarios para ellas, analogos y usos de los mismos. |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
| WO2004072030A2 (en) | 2003-02-05 | 2004-08-26 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine kinase inhibitors |
| TW201319088A (zh) | 2003-07-18 | 2013-05-16 | Amgen Inc | 對肝細胞生長因子具專一性之結合劑 |
| US7102001B2 (en) | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
| US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
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