PE86599A1 - Inhibidores de la farnesil proteina transferasa - Google Patents
Inhibidores de la farnesil proteina transferasaInfo
- Publication number
- PE86599A1 PE86599A1 PE1998000565A PE00056598A PE86599A1 PE 86599 A1 PE86599 A1 PE 86599A1 PE 1998000565 A PE1998000565 A PE 1998000565A PE 00056598 A PE00056598 A PE 00056598A PE 86599 A1 PE86599 A1 PE 86599A1
- Authority
- PE
- Peru
- Prior art keywords
- farnesil
- compound
- protein transferase
- transferasa
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I o II, DONDE l, m, r, s Y t SON 0-1; n ES 0-2; "Y" ES CHR12, SO2, SO3, CO, NR13, SO2NR14, CONR15, NR17CO, C(NCN)NR16, ENTRE OTROS; "Z" ES CR12, S, SO, SO2, ENTRE OTROS; R7 Y R8 SON H, HALO, CIANO, NITRO Y U-R44; U ES S, O, CO, SO, ENTRE OTROS; R9, R10, R12, R13, R14, R15, R16 Y R17 SON H, ALQUILO, ARILO, HETEROCICLO; R11 Y R44 SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R1, R2, R3, R4, R5 Y R6 SON H, ALQUILO, ALQUENILO, ENTRE OTROS; A, B, C Y D SON CARBONO, O, S o N o D NO ESTA PRESENTE; CUANDO "I" Y m SON CERO, n NO ES CERO; R11 ES H, EXCEPTO CUANDO Z ES SO. UN COMPUESTO PREFERIDO ES N-[6-BROMO-1,2,3,4-TETRAHIDRO-1-(1H-IMIDAZOL-4ILMETIL)-3-QUINOLINIL]-1NAFTALENOSULFONAMIDA; ENTRE OTROS. EL COMPUESTO I o II ES INHIBIDOR DE LA FARNESIL PROTEINA TRANSFERASA, PRENIL TRANSFERASA, PUDIENDO SER UTIL PARA INHIBIR TUMORES, TRATAR ENFERMEDADES ASOCIADAS CON LAS VIAS DE TRANSDUCCION DE SENALES QUE OPERAN A TRAVES DE LA RAS, O ASOCIADAS CON PROTEINAS QUE SE MODIFICAN DESPUES DE LA TRADUCCION POR LA ENZIMA FARNESIL TRANSFERASA, GERANIL TRANSFERASA, ENFERMEDADES AUTOINMUNES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5159497P | 1997-07-02 | 1997-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE86599A1 true PE86599A1 (es) | 1999-11-28 |
Family
ID=21972255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000565A PE86599A1 (es) | 1997-07-02 | 1998-06-26 | Inhibidores de la farnesil proteina transferasa |
Country Status (24)
Country | Link |
---|---|
US (2) | US6387926B1 (es) |
EP (1) | EP0994856A4 (es) |
JP (1) | JP2002507989A (es) |
KR (1) | KR100385941B1 (es) |
CN (1) | CN1261880A (es) |
AR (1) | AR016304A1 (es) |
AU (1) | AU734721B2 (es) |
BR (1) | BR9810465A (es) |
CA (1) | CA2294530A1 (es) |
CO (1) | CO4950556A1 (es) |
HU (1) | HUP0004148A3 (es) |
ID (1) | ID24076A (es) |
IL (1) | IL133470A0 (es) |
MY (1) | MY117961A (es) |
NO (1) | NO316117B1 (es) |
NZ (1) | NZ501293A (es) |
PE (1) | PE86599A1 (es) |
PL (1) | PL337697A1 (es) |
RU (1) | RU2211838C2 (es) |
TR (1) | TR199903331T2 (es) |
TW (1) | TW527355B (es) |
UY (1) | UY25074A1 (es) |
WO (1) | WO1999001434A1 (es) |
ZA (1) | ZA985778B (es) |
Families Citing this family (47)
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US6747023B1 (en) * | 1998-08-11 | 2004-06-08 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
WO2000012077A1 (en) * | 1998-09-01 | 2000-03-09 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
AU2478500A (en) | 1998-12-08 | 2000-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
WO2000034437A2 (en) | 1998-12-08 | 2000-06-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
HUP0203973A3 (en) | 1999-12-28 | 2004-07-28 | Eisai Co Ltd | Heterocyclic compounds having sulfonamide groups, pharmaceutical compositions containing them and their use |
GB0023915D0 (en) * | 2000-09-29 | 2000-11-15 | Inst Of Ophthalmology | Treatment of neuroinflammatory disease |
US20040044032A1 (en) * | 2000-11-28 | 2004-03-04 | End David William | Farnesyl protein transfer inhibitors for the treatment of inflammatory bowel disease |
FR2819512B1 (fr) * | 2001-01-18 | 2003-02-21 | Servier Lab | Nouveaux composes cyclo[d] azepane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2819510B1 (fr) * | 2001-01-18 | 2003-10-31 | Servier Lab | Nouveaux composes cyclo[c] azepane, leur procede de preparation et les compositions pharmaceutiques qui le contiennent |
FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
US6740757B2 (en) * | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
AU2003259717A1 (en) * | 2002-08-07 | 2004-02-25 | Bristol-Myers Squibb Company | Modulators of rabggt and methods of use thereof |
FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
BRPI0306214B1 (pt) * | 2002-11-20 | 2017-08-08 | Japan Tobacco Inc. | 4-oxoquinoline compound and use of this as a hiv integrase inhibitor |
WO2005007111A2 (en) * | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
JP4691041B2 (ja) | 2003-11-20 | 2011-06-01 | チルドレンズ ホスピタル メディカル センター | Gtpアーゼ阻害剤および使用方法 |
WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
US20050272068A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | UCH-L1 expression and cancer therapy |
EP1732549A4 (en) * | 2004-03-18 | 2009-11-11 | Brigham & Womens Hospital | METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
WO2005089502A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
WO2005089504A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
WO2005113509A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
US20060160850A1 (en) | 2005-01-18 | 2006-07-20 | Chongqing Sun | Bicyclic heterocycles as cannabinoid receptor modulators |
US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
US7662824B2 (en) | 2005-03-18 | 2010-02-16 | Janssen Pharmaceutica Nv | Acylhydrazones as kinase modulators |
BRPI0613403A2 (pt) | 2005-07-15 | 2009-02-10 | Amr Technology Inc | tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina |
US7826982B2 (en) | 2005-07-29 | 2010-11-02 | Children's Hospital Medical Center | Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE |
US8003624B2 (en) * | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
WO2007075923A2 (en) * | 2005-12-23 | 2007-07-05 | Link Medicine Corporation | Treatment of synucleinopathies |
IN2014CN00613A (es) * | 2006-03-06 | 2015-08-21 | Japan Tobacco Inc | |
WO2008013589A2 (en) * | 2006-04-24 | 2008-01-31 | Gloucester Pharmaceuticals | Treatment of ras-expressing tumors |
RU2456281C2 (ru) * | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
EP2146720A4 (en) * | 2007-05-10 | 2012-01-18 | Amr Technology Inc | ARYLOXY- AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINE AND THEIR USE FOR THE RECOURSE-INHIBITION OF NOREPINEPHRIN, DOPAMINE AND SEROTONINE |
FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2009079765A1 (en) * | 2007-12-21 | 2009-07-02 | Cascade Therapeutics Inc. | Compounds with activity at the 5-ht2c receptor |
US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
JP2012508768A (ja) * | 2008-11-13 | 2012-04-12 | リンク・メディスン・コーポレーション | アザキノリノン誘導体及びその使用 |
US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
CN103864765B (zh) * | 2014-03-05 | 2016-02-10 | 天津药物研究院 | 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途 |
US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
ES2926579T3 (es) | 2016-05-05 | 2022-10-27 | Laurus Labs Ltd | Proceso para la preparación de compuestos intermedios útiles en la preparación de inhibidores del virus de la Hepatitis C (VHC) |
WO2017213210A1 (ja) * | 2016-06-10 | 2017-12-14 | 武田薬品工業株式会社 | 複素環化合物 |
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-
1998
- 1998-05-26 TW TW087108171A patent/TW527355B/zh not_active IP Right Cessation
- 1998-05-29 US US09/087,179 patent/US6387926B1/en not_active Expired - Lifetime
- 1998-06-16 NZ NZ501293A patent/NZ501293A/en unknown
- 1998-06-16 WO PCT/US1998/012549 patent/WO1999001434A1/en not_active Application Discontinuation
- 1998-06-16 AU AU79719/98A patent/AU734721B2/en not_active Ceased
- 1998-06-16 IL IL13347098A patent/IL133470A0/xx unknown
- 1998-06-16 TR TR1999/03331T patent/TR199903331T2/xx unknown
- 1998-06-16 BR BR9810465-9A patent/BR9810465A/pt not_active IP Right Cessation
- 1998-06-16 EP EP98930299A patent/EP0994856A4/en not_active Withdrawn
- 1998-06-16 KR KR10-1999-7012368A patent/KR100385941B1/ko not_active IP Right Cessation
- 1998-06-16 JP JP50718899A patent/JP2002507989A/ja not_active Ceased
- 1998-06-16 PL PL98337697A patent/PL337697A1/xx unknown
- 1998-06-16 CA CA002294530A patent/CA2294530A1/en not_active Abandoned
- 1998-06-16 CN CN98806818A patent/CN1261880A/zh active Pending
- 1998-06-16 HU HU0004148A patent/HUP0004148A3/hu unknown
- 1998-06-16 RU RU2000102355/04A patent/RU2211838C2/ru not_active IP Right Cessation
- 1998-06-26 MY MYPI98002919A patent/MY117961A/en unknown
- 1998-06-26 PE PE1998000565A patent/PE86599A1/es not_active Application Discontinuation
- 1998-06-30 UY UY25074A patent/UY25074A1/es not_active IP Right Cessation
- 1998-07-01 ZA ZA9805778A patent/ZA985778B/xx unknown
- 1998-07-01 CO CO98037149A patent/CO4950556A1/es unknown
- 1998-07-02 AR ARP980103223A patent/AR016304A1/es unknown
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1999
- 1999-06-16 ID IDW991728A patent/ID24076A/id unknown
- 1999-12-30 NO NO19996571A patent/NO316117B1/no unknown
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2000
- 2000-05-05 US US09/566,396 patent/US6602883B1/en not_active Expired - Fee Related
Also Published As
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AU734721B2 (en) | 2001-06-21 |
EP0994856A4 (en) | 2000-12-06 |
NO996571D0 (no) | 1999-12-30 |
JP2002507989A (ja) | 2002-03-12 |
IL133470A0 (en) | 2001-04-30 |
HUP0004148A3 (en) | 2002-09-30 |
AR016304A1 (es) | 2001-07-04 |
MY117961A (en) | 2004-08-30 |
NO996571L (no) | 2000-02-23 |
AU7971998A (en) | 1999-01-25 |
RU2211838C2 (ru) | 2003-09-10 |
CO4950556A1 (es) | 2000-09-01 |
ID24076A (id) | 2000-07-06 |
US6602883B1 (en) | 2003-08-05 |
HUP0004148A2 (hu) | 2001-10-28 |
NO316117B1 (no) | 2003-12-15 |
CN1261880A (zh) | 2000-08-02 |
KR20010014258A (ko) | 2001-02-26 |
ZA985778B (en) | 2000-01-20 |
CA2294530A1 (en) | 1999-01-14 |
TR199903331T2 (xx) | 2000-06-21 |
WO1999001434A1 (en) | 1999-01-14 |
BR9810465A (pt) | 2002-04-16 |
UY25074A1 (es) | 2000-12-29 |
NZ501293A (en) | 2001-10-26 |
EP0994856A1 (en) | 2000-04-26 |
TW527355B (en) | 2003-04-11 |
PL337697A1 (en) | 2000-08-28 |
US6387926B1 (en) | 2002-05-14 |
KR100385941B1 (ko) | 2003-06-09 |
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