BR9810465A - Inibidores da farnesiltransferase de proteìnas - Google Patents
Inibidores da farnesiltransferase de proteìnasInfo
- Publication number
- BR9810465A BR9810465A BR9810465-9A BR9810465A BR9810465A BR 9810465 A BR9810465 A BR 9810465A BR 9810465 A BR9810465 A BR 9810465A BR 9810465 A BR9810465 A BR 9810465A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- farnesyltransferase inhibitors
- protein farnesyltransferase
- compounds
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
"INIBIDORES DA FARNESILTRANSFERASE DE PROTEìNAS" Descreve-se derivados de quinolina e benzazepina que inibem a farnesiltransferase de proteínas (FTase) e a farnesilação da proteína oncogênica Ras. Assim sendo, os compostos são úteis como agentes anticâncer. Os compostos são úteis também no tratamento de doenças que não o câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5159497P | 1997-07-02 | 1997-07-02 | |
PCT/US1998/012549 WO1999001434A1 (en) | 1997-07-02 | 1998-06-16 | Inhibitors of farnesyl protein transferase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810465A true BR9810465A (pt) | 2002-04-16 |
Family
ID=21972255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810465-9A BR9810465A (pt) | 1997-07-02 | 1998-06-16 | Inibidores da farnesiltransferase de proteìnas |
Country Status (24)
Country | Link |
---|---|
US (2) | US6387926B1 (pt) |
EP (1) | EP0994856A4 (pt) |
JP (1) | JP2002507989A (pt) |
KR (1) | KR100385941B1 (pt) |
CN (1) | CN1261880A (pt) |
AR (1) | AR016304A1 (pt) |
AU (1) | AU734721B2 (pt) |
BR (1) | BR9810465A (pt) |
CA (1) | CA2294530A1 (pt) |
CO (1) | CO4950556A1 (pt) |
HU (1) | HUP0004148A3 (pt) |
ID (1) | ID24076A (pt) |
IL (1) | IL133470A0 (pt) |
MY (1) | MY117961A (pt) |
NO (1) | NO316117B1 (pt) |
NZ (1) | NZ501293A (pt) |
PE (1) | PE86599A1 (pt) |
PL (1) | PL337697A1 (pt) |
RU (1) | RU2211838C2 (pt) |
TR (1) | TR199903331T2 (pt) |
TW (1) | TW527355B (pt) |
UY (1) | UY25074A1 (pt) |
WO (1) | WO1999001434A1 (pt) |
ZA (1) | ZA985778B (pt) |
Families Citing this family (47)
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---|---|---|---|---|
WO2000009480A1 (fr) * | 1998-08-11 | 2000-02-24 | Daiichi Pharmaceutical Co., Ltd. | Nouveaux derives sulfonyle |
WO2000012077A1 (en) * | 1998-09-01 | 2000-03-09 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
US6316436B1 (en) | 1998-12-08 | 2001-11-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2477400A (en) | 1998-12-08 | 2000-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
CN1217936C (zh) * | 1999-12-28 | 2005-09-07 | 卫材株式会社 | 含有磺酰胺的杂环化合物 |
GB0023915D0 (en) * | 2000-09-29 | 2000-11-15 | Inst Of Ophthalmology | Treatment of neuroinflammatory disease |
EP1339407B1 (en) * | 2000-11-28 | 2006-04-19 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors for the treatment of inflammatory bowel disease |
FR2819510B1 (fr) * | 2001-01-18 | 2003-10-31 | Servier Lab | Nouveaux composes cyclo[c] azepane, leur procede de preparation et les compositions pharmaceutiques qui le contiennent |
FR2819512B1 (fr) * | 2001-01-18 | 2003-02-21 | Servier Lab | Nouveaux composes cyclo[d] azepane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
US6740757B2 (en) * | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
US20040142888A1 (en) * | 2002-08-07 | 2004-07-22 | Veeraswamy Manne | Modulators of RabGGT and methods of use thereof |
FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
PE20040840A1 (es) * | 2002-11-20 | 2004-12-30 | Japan Tobacco Inc | Derivados de 4-oxoquinolina como inhibidores de la integrasa del vih |
EP1644335A4 (en) * | 2003-07-11 | 2008-06-04 | Bristol Myers Squibb Co | TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS |
WO2005051392A1 (en) | 2003-11-20 | 2005-06-09 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use |
US20050272068A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | UCH-L1 expression and cancer therapy |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
WO2005089504A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
EP1732549A4 (en) * | 2004-03-18 | 2009-11-11 | Brigham & Womens Hospital | METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES |
WO2005089502A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
US7531554B2 (en) * | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
US20060160850A1 (en) | 2005-01-18 | 2006-07-20 | Chongqing Sun | Bicyclic heterocycles as cannabinoid receptor modulators |
US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
WO2006101937A1 (en) | 2005-03-18 | 2006-09-28 | Janssen Pharmaceutica N.V. | Acylhydrazones as kinase modulators |
KR101589551B1 (ko) | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
CA2617056A1 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
US8003624B2 (en) * | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
CA2634598A1 (en) * | 2005-12-23 | 2007-07-05 | Link Medicine Corporation | Treatment of synucleinopathies |
JP4669040B2 (ja) * | 2006-03-06 | 2011-04-13 | 日本たばこ産業株式会社 | 4−オキソキノリン化合物の製造方法 |
CA2650520A1 (en) * | 2006-04-24 | 2008-01-31 | Gloucester Pharmaceuticals | Treatment of ras-expressing tumors |
CA2669112A1 (en) * | 2006-11-16 | 2008-05-22 | F. Hoffmann-La Roche Ag | Substituted 4-imidazoles |
EA017308B1 (ru) * | 2007-05-10 | 2012-11-30 | Олбани Молекьюлар Рисерч, Инк. | Арилокси- и гетероарилоксизамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина |
FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2009079765A1 (en) * | 2007-12-21 | 2009-07-02 | Cascade Therapeutics Inc. | Compounds with activity at the 5-ht2c receptor |
US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
EP2370436A1 (en) * | 2008-11-13 | 2011-10-05 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
CN103864765B (zh) * | 2014-03-05 | 2016-02-10 | 天津药物研究院 | 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途 |
US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
US9957279B2 (en) | 2016-05-05 | 2018-05-01 | Laurus Labs Limited | Process for the preparation of intermediates useful in the preparation of Hepatitis C virus (HCV) inhibitors |
WO2017213210A1 (ja) * | 2016-06-10 | 2017-12-14 | 武田薬品工業株式会社 | 複素環化合物 |
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IL113196A0 (en) * | 1994-03-31 | 1995-06-29 | Bristol Myers Squibb Co | Imidazole derivatives and pharmaceutical compositions containing the same |
US5607939A (en) | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
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TW436484B (en) | 1996-04-24 | 2001-05-28 | Dev Center Biotechnology | 1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof |
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UA60311C2 (uk) | 1996-10-02 | 2003-10-15 | Смітклайн Бічам Корпорейшн | Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція |
-
1998
- 1998-05-26 TW TW087108171A patent/TW527355B/zh not_active IP Right Cessation
- 1998-05-29 US US09/087,179 patent/US6387926B1/en not_active Expired - Lifetime
- 1998-06-16 CN CN98806818A patent/CN1261880A/zh active Pending
- 1998-06-16 CA CA002294530A patent/CA2294530A1/en not_active Abandoned
- 1998-06-16 BR BR9810465-9A patent/BR9810465A/pt not_active IP Right Cessation
- 1998-06-16 AU AU79719/98A patent/AU734721B2/en not_active Ceased
- 1998-06-16 WO PCT/US1998/012549 patent/WO1999001434A1/en not_active Application Discontinuation
- 1998-06-16 HU HU0004148A patent/HUP0004148A3/hu unknown
- 1998-06-16 IL IL13347098A patent/IL133470A0/xx unknown
- 1998-06-16 TR TR1999/03331T patent/TR199903331T2/xx unknown
- 1998-06-16 RU RU2000102355/04A patent/RU2211838C2/ru not_active IP Right Cessation
- 1998-06-16 NZ NZ501293A patent/NZ501293A/en unknown
- 1998-06-16 PL PL98337697A patent/PL337697A1/xx unknown
- 1998-06-16 KR KR10-1999-7012368A patent/KR100385941B1/ko not_active IP Right Cessation
- 1998-06-16 EP EP98930299A patent/EP0994856A4/en not_active Withdrawn
- 1998-06-16 JP JP50718899A patent/JP2002507989A/ja not_active Ceased
- 1998-06-26 MY MYPI98002919A patent/MY117961A/en unknown
- 1998-06-26 PE PE1998000565A patent/PE86599A1/es not_active Application Discontinuation
- 1998-06-30 UY UY25074A patent/UY25074A1/es not_active IP Right Cessation
- 1998-07-01 ZA ZA9805778A patent/ZA985778B/xx unknown
- 1998-07-01 CO CO98037149A patent/CO4950556A1/es unknown
- 1998-07-02 AR ARP980103223A patent/AR016304A1/es unknown
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1999
- 1999-06-16 ID IDW991728A patent/ID24076A/id unknown
- 1999-12-30 NO NO19996571A patent/NO316117B1/no unknown
-
2000
- 2000-05-05 US US09/566,396 patent/US6602883B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO316117B1 (no) | 2003-12-15 |
KR100385941B1 (ko) | 2003-06-09 |
HUP0004148A2 (hu) | 2001-10-28 |
HUP0004148A3 (en) | 2002-09-30 |
NZ501293A (en) | 2001-10-26 |
KR20010014258A (ko) | 2001-02-26 |
ZA985778B (en) | 2000-01-20 |
CA2294530A1 (en) | 1999-01-14 |
AU734721B2 (en) | 2001-06-21 |
PL337697A1 (en) | 2000-08-28 |
ID24076A (id) | 2000-07-06 |
JP2002507989A (ja) | 2002-03-12 |
EP0994856A1 (en) | 2000-04-26 |
US6387926B1 (en) | 2002-05-14 |
CO4950556A1 (es) | 2000-09-01 |
AR016304A1 (es) | 2001-07-04 |
TR199903331T2 (xx) | 2000-06-21 |
MY117961A (en) | 2004-08-30 |
NO996571D0 (no) | 1999-12-30 |
TW527355B (en) | 2003-04-11 |
RU2211838C2 (ru) | 2003-09-10 |
CN1261880A (zh) | 2000-08-02 |
WO1999001434A1 (en) | 1999-01-14 |
US6602883B1 (en) | 2003-08-05 |
PE86599A1 (es) | 1999-11-28 |
UY25074A1 (es) | 2000-12-29 |
NO996571L (no) | 2000-02-23 |
EP0994856A4 (en) | 2000-12-06 |
IL133470A0 (en) | 2001-04-30 |
AU7971998A (en) | 1999-01-25 |
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