BR9814188A - "agonistas de 5-ht1f" - Google Patents

"agonistas de 5-ht1f"

Info

Publication number
BR9814188A
BR9814188A BR9814188-0A BR9814188A BR9814188A BR 9814188 A BR9814188 A BR 9814188A BR 9814188 A BR9814188 A BR 9814188A BR 9814188 A BR9814188 A BR 9814188A
Authority
BR
Brazil
Prior art keywords
agonists
ht1f agonists
employing
ht1f
compounds
Prior art date
Application number
BR9814188-0A
Other languages
English (en)
Inventor
Sandra Ann Filla
Brian Michael Mathes
John Mehnert Schaus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9814188A publication Critical patent/BR9814188A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

Patente de Invenção: <B>"AGONISTAS DE 5-HT~ 1F~"<D>. A invenção providencia agonistas de 5-HT~ 1F~ de Fórmula (I) onde A-B, X e R são definidos no relatório descritivo. A invenção também inclui formulações farmacêuticas empregando os compostos da invenção, bem como métodos de tratamento de condições associadas com a ativação de 5-HT~ 1F~ empregando esses compostos ou composições.
BR9814188-0A 1997-11-14 1998-11-13 "agonistas de 5-ht1f" BR9814188A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/970,637 US5905084A (en) 1997-11-14 1997-11-14 5-HTIF -agonists effective in treating migraine
PCT/US1998/024256 WO1999025348A1 (en) 1997-11-14 1998-11-13 5-ht1f agonists

Publications (1)

Publication Number Publication Date
BR9814188A true BR9814188A (pt) 2000-10-03

Family

ID=25517243

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814188-0A BR9814188A (pt) 1997-11-14 1998-11-13 "agonistas de 5-ht1f"

Country Status (22)

Country Link
US (1) US5905084A (pt)
EP (1) EP0916670B1 (pt)
JP (1) JP2001522887A (pt)
KR (1) KR20010032085A (pt)
CN (1) CN1284874A (pt)
AT (1) ATE240326T1 (pt)
AU (1) AU1407299A (pt)
BR (1) BR9814188A (pt)
CA (1) CA2310248A1 (pt)
DE (1) DE69814563T2 (pt)
DK (1) DK0916670T3 (pt)
EA (1) EA200000522A1 (pt)
ES (1) ES2198657T3 (pt)
HR (1) HRP20000297A2 (pt)
HU (1) HUP0004317A3 (pt)
ID (1) ID25478A (pt)
IL (1) IL135634A0 (pt)
NO (1) NO20002408L (pt)
PL (1) PL340459A1 (pt)
PT (1) PT916670E (pt)
TR (1) TR200001724T2 (pt)
WO (1) WO1999025348A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1204662B1 (en) * 1999-08-12 2004-06-02 NPS Allelix Corp. Azaindoles having serotonin receptor affinity
WO2001029263A1 (en) * 1999-10-19 2001-04-26 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1e gene
TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
EP1626958B1 (en) 2003-04-18 2012-06-27 Eli Lilly And Company (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht 1f agonists
UA82711C2 (en) 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
EP1697305B1 (en) 2003-12-17 2007-08-15 Eli Lilly And Company Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists
US8030344B2 (en) * 2007-03-13 2011-10-04 Methylgene Inc. Inhibitors of histone deacetylase
WO2011123654A1 (en) 2010-04-02 2011-10-06 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists
TWI829107B (zh) 2019-07-09 2024-01-11 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
US5942536A (en) * 1995-10-10 1999-08-24 Eli Lilly And Company N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists

Also Published As

Publication number Publication date
EP0916670B1 (en) 2003-05-14
HUP0004317A2 (hu) 2001-10-28
DK0916670T3 (da) 2003-09-15
PL340459A1 (en) 2001-02-12
KR20010032085A (ko) 2001-04-16
ES2198657T3 (es) 2004-02-01
IL135634A0 (en) 2001-05-20
TR200001724T2 (tr) 2000-11-21
WO1999025348A1 (en) 1999-05-27
ID25478A (id) 2000-10-05
PT916670E (pt) 2003-09-30
JP2001522887A (ja) 2001-11-20
DE69814563D1 (de) 2003-06-18
EP0916670A2 (en) 1999-05-19
DE69814563T2 (de) 2004-04-08
HRP20000297A2 (en) 2000-12-31
AU1407299A (en) 1999-06-07
NO20002408L (no) 2000-07-12
NO20002408D0 (no) 2000-05-09
CA2310248A1 (en) 1999-05-27
US5905084A (en) 1999-05-18
CN1284874A (zh) 2001-02-21
EP0916670A3 (en) 2001-05-23
HUP0004317A3 (en) 2002-03-28
EA200000522A1 (ru) 2000-10-30
ATE240326T1 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
ATE253063T1 (de) 5-ht1f-agonisten
BR0007527A (pt) Fenilfenantridinas com atividade inibitória depde-iv
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
NO20015226L (no) Tri-aryl syrederivater som PPAR reseptor ligander, farmasoytisk sammensetning omfattende samme og anvendelse av samme for fremstilling av medikament.
ATE231872T1 (de) Thiazolopyrimidinderivate
DK1200418T3 (da) Nematodicide trifluorbutener
BR0208741A (pt) Derivados de piperidina
BR0007589A (pt) Inibidores da proliferação de células
BR9713338A (pt) Benzonaftiridinas como terapêuticos brÈnquicos.
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
BR9810610A (pt) Carboxamidas utilizáveis como agonistas 5-ht1f
BR9814188A (pt) &#34;agonistas de 5-ht1f&#34;
BR0001201A (pt) Composto ( poli ) tia-alcinóicos, composição cosmética, utilização de uma composição cosmética, utilização de um composto e composição farmacêutica
BR9902084A (pt) Heterociclos.
NO20020914D0 (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
DE60003074D1 (de) Fusidinsäure-derivate
TR200100182T2 (tr) Antitrombotik etkili ikame edilmiş fenilamidinler
ATE190316T1 (de) Peptid-aldehydderivate als antikoagulierende mittel
BR9803717A (pt) ácidos indol-2-carbocìlicos substituìdos como inibidores de glucosil transferase.
BR9915333A (pt) Derivados de 3,4-dihidroquinolina fluorada como inibidores de nos

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]