DE69814563D1 - Pyrrolo-(3,2-b)pyridine und ihre Verwendung als 5-HT1F Agonisten - Google Patents
Pyrrolo-(3,2-b)pyridine und ihre Verwendung als 5-HT1F AgonistenInfo
- Publication number
- DE69814563D1 DE69814563D1 DE69814563T DE69814563T DE69814563D1 DE 69814563 D1 DE69814563 D1 DE 69814563D1 DE 69814563 T DE69814563 T DE 69814563T DE 69814563 T DE69814563 T DE 69814563T DE 69814563 D1 DE69814563 D1 DE 69814563D1
- Authority
- DE
- Germany
- Prior art keywords
- pyridines
- pyrrolo
- ht1f
- ht1f agonists
- agonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US970637 | 1997-11-14 | ||
US08/970,637 US5905084A (en) | 1997-11-14 | 1997-11-14 | 5-HTIF -agonists effective in treating migraine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69814563D1 true DE69814563D1 (de) | 2003-06-18 |
DE69814563T2 DE69814563T2 (de) | 2004-04-08 |
Family
ID=25517243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69814563T Expired - Fee Related DE69814563T2 (de) | 1997-11-14 | 1998-11-13 | Pyrrolo-(3,2-b)pyridine und ihre Verwendung als 5-HT1F Agonisten |
Country Status (22)
Country | Link |
---|---|
US (1) | US5905084A (de) |
EP (1) | EP0916670B1 (de) |
JP (1) | JP2001522887A (de) |
KR (1) | KR20010032085A (de) |
CN (1) | CN1284874A (de) |
AT (1) | ATE240326T1 (de) |
AU (1) | AU1407299A (de) |
BR (1) | BR9814188A (de) |
CA (1) | CA2310248A1 (de) |
DE (1) | DE69814563T2 (de) |
DK (1) | DK0916670T3 (de) |
EA (1) | EA200000522A1 (de) |
ES (1) | ES2198657T3 (de) |
HR (1) | HRP20000297A2 (de) |
HU (1) | HUP0004317A3 (de) |
ID (1) | ID25478A (de) |
IL (1) | IL135634A0 (de) |
NO (1) | NO20002408L (de) |
PL (1) | PL340459A1 (de) |
PT (1) | PT916670E (de) |
TR (1) | TR200001724T2 (de) |
WO (1) | WO1999025348A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU779832B2 (en) * | 1999-08-12 | 2005-02-10 | Nps Pharmaceuticals, Inc. | Azaindoles having serotonin receptor affinity |
WO2001029263A1 (en) * | 1999-10-19 | 2001-04-26 | Genaissance Pharmaceuticals, Inc. | Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1e gene |
TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
AU2004232799A1 (en) | 2003-04-18 | 2004-11-04 | Eli Lilly And Company | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists |
UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
WO2005061439A1 (en) | 2003-12-17 | 2005-07-07 | Eli Lilly And Company | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists |
US8030344B2 (en) * | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2011123654A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
TWI776175B (zh) | 2019-07-09 | 2022-09-01 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體,以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990007926A1 (en) * | 1989-01-20 | 1990-07-26 | Pfizer Inc. | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines |
US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
GB9423460D0 (en) * | 1994-11-21 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
JPH11502816A (ja) * | 1995-03-20 | 1999-03-09 | イーライ・リリー・アンド・カンパニー | 5−置換−3−(1,2,3,6−テトラヒドロピリジン−4−イル)−および3−(ピペリジン−4−イル)−1h−インドール類:新規5−ht▲下1f▼アゴニスト |
JPH11513666A (ja) * | 1995-10-10 | 1999-11-24 | イーライ・リリー・アンド・カンパニー | N−[2−置換−3−(2−アミノエチル)−1h−インドール−5−イル]−アミド:新規5−ht▲下1f▼作動剤 |
ZA979961B (en) * | 1996-11-15 | 1999-05-05 | Lilly Co Eli | 5-HT1F agonists |
-
1997
- 1997-11-14 US US08/970,637 patent/US5905084A/en not_active Expired - Fee Related
-
1998
- 1998-11-13 PT PT98309321T patent/PT916670E/pt unknown
- 1998-11-13 TR TR2000/01724T patent/TR200001724T2/xx unknown
- 1998-11-13 DE DE69814563T patent/DE69814563T2/de not_active Expired - Fee Related
- 1998-11-13 AT AT98309321T patent/ATE240326T1/de not_active IP Right Cessation
- 1998-11-13 CN CN98812914A patent/CN1284874A/zh active Pending
- 1998-11-13 PL PL98340459A patent/PL340459A1/xx unknown
- 1998-11-13 AU AU14072/99A patent/AU1407299A/en not_active Abandoned
- 1998-11-13 ES ES98309321T patent/ES2198657T3/es not_active Expired - Lifetime
- 1998-11-13 KR KR1020007005209A patent/KR20010032085A/ko not_active Application Discontinuation
- 1998-11-13 DK DK98309321T patent/DK0916670T3/da active
- 1998-11-13 EP EP98309321A patent/EP0916670B1/de not_active Expired - Lifetime
- 1998-11-13 CA CA002310248A patent/CA2310248A1/en not_active Abandoned
- 1998-11-13 ID IDW20000837A patent/ID25478A/id unknown
- 1998-11-13 WO PCT/US1998/024256 patent/WO1999025348A1/en not_active Application Discontinuation
- 1998-11-13 BR BR9814188-0A patent/BR9814188A/pt not_active Application Discontinuation
- 1998-11-13 HU HU0004317A patent/HUP0004317A3/hu unknown
- 1998-11-13 JP JP2000520781A patent/JP2001522887A/ja not_active Withdrawn
- 1998-11-13 EA EA200000522A patent/EA200000522A1/ru unknown
- 1998-11-13 IL IL13563498A patent/IL135634A0/xx unknown
-
2000
- 2000-05-09 NO NO20002408A patent/NO20002408L/no not_active Application Discontinuation
- 2000-05-12 HR HR20000297A patent/HRP20000297A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL340459A1 (en) | 2001-02-12 |
ID25478A (id) | 2000-10-05 |
ES2198657T3 (es) | 2004-02-01 |
NO20002408L (no) | 2000-07-12 |
BR9814188A (pt) | 2000-10-03 |
IL135634A0 (en) | 2001-05-20 |
HUP0004317A2 (hu) | 2001-10-28 |
DK0916670T3 (da) | 2003-09-15 |
HRP20000297A2 (en) | 2000-12-31 |
EP0916670B1 (de) | 2003-05-14 |
DE69814563T2 (de) | 2004-04-08 |
EP0916670A2 (de) | 1999-05-19 |
HUP0004317A3 (en) | 2002-03-28 |
EA200000522A1 (ru) | 2000-10-30 |
WO1999025348A1 (en) | 1999-05-27 |
PT916670E (pt) | 2003-09-30 |
US5905084A (en) | 1999-05-18 |
KR20010032085A (ko) | 2001-04-16 |
EP0916670A3 (de) | 2001-05-23 |
AU1407299A (en) | 1999-06-07 |
CA2310248A1 (en) | 1999-05-27 |
TR200001724T2 (tr) | 2000-11-21 |
JP2001522887A (ja) | 2001-11-20 |
CN1284874A (zh) | 2001-02-21 |
NO20002408D0 (no) | 2000-05-09 |
ATE240326T1 (de) | 2003-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |