DE69331774D1 - 7-Substituierte-8-substituierte-9-substituierte Amino-7-Demethyl-6-Deoxy-Tetracycline als antibiotische Mittel - Google Patents

7-Substituierte-8-substituierte-9-substituierte Amino-7-Demethyl-6-Deoxy-Tetracycline als antibiotische Mittel

Info

Publication number
DE69331774D1
DE69331774D1 DE69331774T DE69331774T DE69331774D1 DE 69331774 D1 DE69331774 D1 DE 69331774D1 DE 69331774 T DE69331774 T DE 69331774T DE 69331774 T DE69331774 T DE 69331774T DE 69331774 D1 DE69331774 D1 DE 69331774D1
Authority
DE
Germany
Prior art keywords
substituted
demethyl
tetracyclines
deoxy
antibiotic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69331774T
Other languages
English (en)
Other versions
DE69331774T2 (de
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Raymond T Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE69331774D1 publication Critical patent/DE69331774D1/de
Publication of DE69331774T2 publication Critical patent/DE69331774T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Seasonings (AREA)
DE69331774T 1992-08-13 1993-06-21 7-Substituierte-8-substituierte-9-substituierte Amino-7-Demethyl-6-Deoxy-Tetracycline als antibiotische Mittel Expired - Fee Related DE69331774T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (2)

Publication Number Publication Date
DE69331774D1 true DE69331774D1 (de) 2002-05-08
DE69331774T2 DE69331774T2 (de) 2002-11-14

Family

ID=25456505

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331774T Expired - Fee Related DE69331774T2 (de) 1992-08-13 1993-06-21 7-Substituierte-8-substituierte-9-substituierte Amino-7-Demethyl-6-Deoxy-Tetracycline als antibiotische Mittel

Country Status (24)

Country Link
US (4) US5430162A (de)
EP (1) EP0582810B1 (de)
JP (1) JP3639313B2 (de)
KR (1) KR100309540B1 (de)
CN (1) CN1048719C (de)
AT (1) ATE215530T1 (de)
AU (1) AU674524B2 (de)
CA (1) CA2103861C (de)
CZ (1) CZ289195B6 (de)
DE (1) DE69331774T2 (de)
DK (1) DK0582810T3 (de)
ES (1) ES2173876T3 (de)
FI (1) FI933567A (de)
HU (2) HU213269B (de)
IL (4) IL106677A (de)
NO (1) NO302568B1 (de)
NZ (1) NZ248359A (de)
PH (1) PH31210A (de)
PL (4) PL174022B1 (de)
PT (1) PT582810E (de)
RU (1) RU2127255C1 (de)
SG (1) SG47520A1 (de)
SK (1) SK281871B6 (de)
ZA (1) ZA935892B (de)

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US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
DK1240133T3 (da) * 1999-09-14 2006-08-21 Tufts College Fremgangsmåde til fremstilling af substituerede tetracycliner med overgangsmetalbaserede kemiske metoder
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
JP2004505012A (ja) * 2000-03-31 2004-02-19 トラスティーズ・オブ・タフツ・カレッジ ７−および９−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
NZ522733A (en) * 2000-06-02 2004-05-28 Yu Liu Non-antibacterial tetracycline as anti-fungal agents
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
HUP0301163A3 (en) * 2000-07-07 2008-08-28 Tufts College 7-substituted tetracycline dervatives, pharmaceutical compositions containing them and their use
DE60144375D1 (de) * 2000-07-07 2011-05-19 Trustees Of Tufts College Medford 7-, 8- und 9-substitutierte tetracyclinverbindungen
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US6846939B2 (en) * 2000-07-07 2005-01-25 Paratek Pharmaceuticals, Inc. 9-substituted minocycline compounds
EP1241160A1 (de) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
IL157860A0 (en) 2001-03-13 2004-03-28 Paratek Pharm Innc 7,9-substituted tetracycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
DE60235083D1 (de) * 2001-04-24 2010-03-04 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP1408987B1 (de) 2001-07-13 2013-04-10 Paratek Pharmaceuticals, Inc. Tetracyclin-verbindungen mit therapeutischen zielaktivitäten
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
EP2311798A1 (de) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
EA200802365A1 (ru) * 2002-03-08 2009-08-28 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
IL164180A0 (en) * 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
WO2003092629A2 (en) * 2002-05-06 2003-11-13 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
US20040029843A1 (en) * 2002-06-20 2004-02-12 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
WO2004006850A2 (en) 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
EP1556007A4 (de) * 2002-10-24 2008-12-17 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CA2553510C (en) 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
KR101336462B1 (ko) 2004-05-21 2013-12-04 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2949644A3 (de) 2004-10-25 2016-04-20 Paratek Pharmaceuticals, Inc. Substituierte tetracyclin-verbindungen
US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
CA2597212A1 (en) * 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
AU2006331688A1 (en) * 2005-12-22 2007-07-05 Wyeth Oral formulations comprising tigecycline
EP1962860A1 (de) * 2005-12-22 2008-09-03 Wyeth Verfahren zur behandlung von infektionen des magen-darm-trakts mit tigecyclin
CA2652346A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
AR061485A1 (es) * 2006-06-15 2008-08-27 Serenex Inc Composiciones estabilizadas de tetraciclina
DK2225253T3 (da) 2007-11-29 2012-08-27 Actelion Pharmaceuticals Ltd Phosphonsyrederivater og deres anvendelse som p2y12- receptorantagonister
ES2558512T3 (es) 2008-08-08 2016-02-04 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida con C7-fluoro
EP2424834B1 (de) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthese von tetracyclinen und deren zwischenprodukte
CN102459153A (zh) * 2009-05-08 2012-05-16 四相制药公司 四环素类化合物
CN105622496B (zh) 2009-08-28 2019-03-05 四相制药公司 四环素类化合物
PT2890673T (pt) 2012-08-31 2019-02-19 Tetraphase Pharmaceuticals Inc Compostos de tetraciclina
US10961190B2 (en) 2016-10-19 2021-03-30 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline

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US3007965A (en) * 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
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USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
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Also Published As

Publication number Publication date
DK0582810T3 (da) 2002-06-03
US5430162A (en) 1995-07-04
PL175487B1 (pl) 1999-01-29
PH31210A (en) 1998-05-05
HU213269B (en) 1997-04-28
SK85793A3 (en) 1994-04-06
CZ157593A3 (en) 1994-02-16
AU4460193A (en) 1994-02-17
SK281871B6 (sk) 2001-08-06
PL174127B1 (pl) 1998-06-30
PL174022B1 (pl) 1998-06-30
NO932872D0 (no) 1993-08-12
US5495018A (en) 1996-02-27
FI933567A (fi) 1994-02-14
RU2127255C1 (ru) 1999-03-10
CZ289195B6 (cs) 2001-11-14
US5886175A (en) 1999-03-23
NO302568B1 (no) 1998-03-23
NO932872L (no) 1994-02-14
ATE215530T1 (de) 2002-04-15
JP3639313B2 (ja) 2005-04-20
ES2173876T3 (es) 2002-11-01
KR940003925A (ko) 1994-03-14
IL119751A (en) 1998-09-24
PT582810E (pt) 2002-08-30
CN1048719C (zh) 2000-01-26
HU211303A9 (en) 1995-11-28
JPH06228072A (ja) 1994-08-16
CA2103861C (en) 2004-07-27
IL106677A0 (en) 1993-12-08
ZA935892B (en) 1994-03-10
DE69331774T2 (de) 2002-11-14
IL119750A (en) 1998-09-24
SG47520A1 (en) 1998-04-17
EP0582810B1 (de) 2002-04-03
NZ248359A (en) 1996-03-26
HU9302333D0 (en) 1993-10-28
KR100309540B1 (ko) 2002-04-24
CN1090267A (zh) 1994-08-03
CA2103861A1 (en) 1994-02-14
US5512553A (en) 1996-04-30
IL106677A (en) 1998-06-15
PL300066A1 (en) 1994-02-21
PL174230B1 (pl) 1998-07-31
HUT64945A (en) 1994-03-28
IL119750A0 (en) 1997-03-18
AU674524B2 (en) 1997-01-02
EP0582810A1 (de) 1994-02-16
FI933567A0 (fi) 1993-08-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US

8339 Ceased/non-payment of the annual fee