NO302568B1 - Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem - Google Patents

Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem

Info

Publication number
NO302568B1
NO302568B1 NO932872A NO932872A NO302568B1 NO 302568 B1 NO302568 B1 NO 302568B1 NO 932872 A NO932872 A NO 932872A NO 932872 A NO932872 A NO 932872A NO 302568 B1 NO302568 B1 NO 302568B1
Authority
NO
Norway
Prior art keywords
substituted
demethyl
tetracyclines
deoxy
intermediates
Prior art date
Application number
NO932872A
Other languages
English (en)
Other versions
NO932872L (no
NO932872D0 (no
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Raymond T Testa
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NO932872D0 publication Critical patent/NO932872D0/no
Publication of NO932872L publication Critical patent/NO932872L/no
Publication of NO302568B1 publication Critical patent/NO302568B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
NO932872A 1992-08-13 1993-08-12 Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem NO302568B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (3)

Publication Number Publication Date
NO932872D0 NO932872D0 (no) 1993-08-12
NO932872L NO932872L (no) 1994-02-14
NO302568B1 true NO302568B1 (no) 1998-03-23

Family

ID=25456505

Family Applications (1)

Application Number Title Priority Date Filing Date
NO932872A NO302568B1 (no) 1992-08-13 1993-08-12 Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem

Country Status (24)

Country Link
US (4) US5430162A (no)
EP (1) EP0582810B1 (no)
JP (1) JP3639313B2 (no)
KR (1) KR100309540B1 (no)
CN (1) CN1048719C (no)
AT (1) ATE215530T1 (no)
AU (1) AU674524B2 (no)
CA (1) CA2103861C (no)
CZ (1) CZ289195B6 (no)
DE (1) DE69331774T2 (no)
DK (1) DK0582810T3 (no)
ES (1) ES2173876T3 (no)
FI (1) FI933567A (no)
HU (2) HU213269B (no)
IL (4) IL106677A (no)
NO (1) NO302568B1 (no)
NZ (1) NZ248359A (no)
PH (1) PH31210A (no)
PL (4) PL174230B1 (no)
PT (1) PT582810E (no)
RU (1) RU2127255C1 (no)
SG (1) SG47520A1 (no)
SK (1) SK281871B6 (no)
ZA (1) ZA935892B (no)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
ATE323671T1 (de) * 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CA2404628A1 (en) * 2000-03-31 2001-10-11 Stuart B. Levy 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
DE60108873D1 (de) * 2000-06-02 2005-03-17 Yu Liu Nicht-antibakterielle tetrazykline als anti-pilz medikamente
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002004404A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
ATE336481T1 (de) * 2000-07-07 2006-09-15 Tufts College 9-substituierte minocyclinverbindungen
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
CZ20032780A3 (cs) 2001-03-13 2004-01-14 Paratek Pharmaceuticals, Inc. 7,9- Substituované tetracyklinové sloučeniny
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
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CN102531948A (zh) * 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
CA2500134A1 (en) * 2002-05-06 2003-11-13 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
WO2004000223A2 (en) * 2002-06-20 2003-12-31 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
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CA2502464A1 (en) * 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
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Also Published As

Publication number Publication date
CA2103861C (en) 2004-07-27
SG47520A1 (en) 1998-04-17
ES2173876T3 (es) 2002-11-01
US5430162A (en) 1995-07-04
ATE215530T1 (de) 2002-04-15
SK281871B6 (sk) 2001-08-06
JPH06228072A (ja) 1994-08-16
NO932872L (no) 1994-02-14
CN1048719C (zh) 2000-01-26
IL106677A (en) 1998-06-15
AU4460193A (en) 1994-02-17
DE69331774T2 (de) 2002-11-14
HU9302333D0 (en) 1993-10-28
US5886175A (en) 1999-03-23
KR100309540B1 (ko) 2002-04-24
CZ157593A3 (en) 1994-02-16
PL174127B1 (pl) 1998-06-30
IL119750A0 (en) 1997-03-18
DE69331774D1 (de) 2002-05-08
PL300066A1 (en) 1994-02-21
FI933567A0 (fi) 1993-08-12
NZ248359A (en) 1996-03-26
FI933567A (fi) 1994-02-14
PH31210A (en) 1998-05-05
PL175487B1 (pl) 1999-01-29
PL174230B1 (pl) 1998-07-31
ZA935892B (en) 1994-03-10
US5512553A (en) 1996-04-30
DK0582810T3 (da) 2002-06-03
IL106677A0 (en) 1993-12-08
PL174022B1 (pl) 1998-06-30
KR940003925A (ko) 1994-03-14
JP3639313B2 (ja) 2005-04-20
HU213269B (en) 1997-04-28
US5495018A (en) 1996-02-27
HU211303A9 (en) 1995-11-28
PT582810E (pt) 2002-08-30
RU2127255C1 (ru) 1999-03-10
AU674524B2 (en) 1997-01-02
HUT64945A (en) 1994-03-28
IL119751A (en) 1998-09-24
CZ289195B6 (cs) 2001-11-14
EP0582810A1 (en) 1994-02-16
IL119750A (en) 1998-09-24
NO932872D0 (no) 1993-08-12
CN1090267A (zh) 1994-08-03
CA2103861A1 (en) 1994-02-14
SK85793A3 (en) 1994-04-06
EP0582810B1 (en) 2002-04-03

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