DK0582810T3 - Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler - Google Patents

Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler

Info

Publication number
DK0582810T3
DK0582810T3 DK93109850T DK93109850T DK0582810T3 DK 0582810 T3 DK0582810 T3 DK 0582810T3 DK 93109850 T DK93109850 T DK 93109850T DK 93109850 T DK93109850 T DK 93109850T DK 0582810 T3 DK0582810 T3 DK 0582810T3
Authority
DK
Denmark
Prior art keywords
substituted
deoxytetracyclines
demethyl
antibiotics
new
Prior art date
Application number
DK93109850T
Other languages
English (en)
Inventor
Ving J Lee
Joseph J Hlavka
Phaik-Eng Sum
Raymond T Testa
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0582810T3 publication Critical patent/DK0582810T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
DK93109850T 1992-08-13 1993-06-21 Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler DK0582810T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (1)

Publication Number Publication Date
DK0582810T3 true DK0582810T3 (da) 2002-06-03

Family

ID=25456505

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93109850T DK0582810T3 (da) 1992-08-13 1993-06-21 Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler

Country Status (24)

Country Link
US (4) US5430162A (da)
EP (1) EP0582810B1 (da)
JP (1) JP3639313B2 (da)
KR (1) KR100309540B1 (da)
CN (1) CN1048719C (da)
AT (1) ATE215530T1 (da)
AU (1) AU674524B2 (da)
CA (1) CA2103861C (da)
CZ (1) CZ289195B6 (da)
DE (1) DE69331774T2 (da)
DK (1) DK0582810T3 (da)
ES (1) ES2173876T3 (da)
FI (1) FI933567A (da)
HU (2) HU213269B (da)
IL (4) IL119750A (da)
NO (1) NO302568B1 (da)
NZ (1) NZ248359A (da)
PH (1) PH31210A (da)
PL (4) PL174022B1 (da)
PT (1) PT582810E (da)
RU (1) RU2127255C1 (da)
SG (1) SG47520A1 (da)
SK (1) SK281871B6 (da)
ZA (1) ZA935892B (da)

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US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
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US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ATE323671T1 (de) * 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
EA200201046A1 (ru) * 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
EP1296703B1 (en) * 2000-06-02 2005-02-09 Yu Liu Non-antibacterial tetracycline as anti-fungal agents
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CZ2003343A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
ATE544745T1 (de) * 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
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CZ20032780A3 (cs) 2001-03-13 2004-01-14 Paratek Pharmaceuticals, Inc. 7,9- Substituované tetracyklinové sloučeniny
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
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EP1482926A4 (en) * 2002-03-08 2006-04-12 Paratek Pharm Innc AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
KR101025400B1 (ko) * 2002-03-21 2011-03-28 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
US20050153943A1 (en) * 2002-05-06 2005-07-14 Ashley Robert A. Methods of simultaneously treating mucositis and fungal infection
WO2004000223A2 (en) * 2002-06-20 2003-12-31 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
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EP2319829A1 (en) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. 9-substituted tetracycline compounds
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SI1753713T1 (sl) 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
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Also Published As

Publication number Publication date
RU2127255C1 (ru) 1999-03-10
DE69331774T2 (de) 2002-11-14
PL174022B1 (pl) 1998-06-30
ES2173876T3 (es) 2002-11-01
US5495018A (en) 1996-02-27
SK85793A3 (en) 1994-04-06
IL119750A0 (en) 1997-03-18
CA2103861C (en) 2004-07-27
US5430162A (en) 1995-07-04
FI933567A (fi) 1994-02-14
HU9302333D0 (en) 1993-10-28
PT582810E (pt) 2002-08-30
CA2103861A1 (en) 1994-02-14
NO302568B1 (no) 1998-03-23
IL119751A (en) 1998-09-24
PL300066A1 (en) 1994-02-21
JP3639313B2 (ja) 2005-04-20
PL174230B1 (pl) 1998-07-31
ATE215530T1 (de) 2002-04-15
AU4460193A (en) 1994-02-17
US5512553A (en) 1996-04-30
IL119750A (en) 1998-09-24
NO932872D0 (no) 1993-08-12
PL175487B1 (pl) 1999-01-29
PL174127B1 (pl) 1998-06-30
FI933567A0 (fi) 1993-08-12
DE69331774D1 (de) 2002-05-08
HU213269B (en) 1997-04-28
HU211303A9 (en) 1995-11-28
IL106677A0 (en) 1993-12-08
US5886175A (en) 1999-03-23
CN1048719C (zh) 2000-01-26
AU674524B2 (en) 1997-01-02
EP0582810A1 (en) 1994-02-16
HUT64945A (en) 1994-03-28
KR940003925A (ko) 1994-03-14
CZ289195B6 (cs) 2001-11-14
NO932872L (no) 1994-02-14
SG47520A1 (en) 1998-04-17
IL106677A (en) 1998-06-15
NZ248359A (en) 1996-03-26
CZ157593A3 (en) 1994-02-16
SK281871B6 (sk) 2001-08-06
KR100309540B1 (ko) 2002-04-24
ZA935892B (en) 1994-03-10
EP0582810B1 (en) 2002-04-03
JPH06228072A (ja) 1994-08-16
CN1090267A (zh) 1994-08-03
PH31210A (en) 1998-05-05

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