EA200201046A1 - 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное - Google Patents
7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производноеInfo
- Publication number
- EA200201046A1 EA200201046A1 EA200201046A EA200201046A EA200201046A1 EA 200201046 A1 EA200201046 A1 EA 200201046A1 EA 200201046 A EA200201046 A EA 200201046A EA 200201046 A EA200201046 A EA 200201046A EA 200201046 A1 EA200201046 A1 EA 200201046A1
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- EA
- Eurasian Patent Office
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Abstract
Предложены замещенные соединения тетрациклина, способы их синтеза и применения. Описаны также тетрациклины, пригодные для лечения чувствительных к тетрациклину нарушений. Включены также промежуточные соединения, используемые для синтеза других соединений тетрациклина.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19387900P | 2000-03-31 | 2000-03-31 | |
US19397200P | 2000-03-31 | 2000-03-31 | |
US28036701P | 2001-03-29 | 2001-03-29 | |
PCT/US2001/010342 WO2001074761A1 (en) | 2000-03-31 | 2001-03-30 | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
Publications (1)
Publication Number | Publication Date |
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EA200201046A1 true EA200201046A1 (ru) | 2003-04-24 |
Family
ID=27393263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200201046A EA200201046A1 (ru) | 2000-03-31 | 2001-03-30 | 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное |
Country Status (18)
Country | Link |
---|---|
US (3) | US6818634B2 (ru) |
EP (1) | EP1272459B1 (ru) |
JP (1) | JP2004505012A (ru) |
KR (1) | KR20030007489A (ru) |
CN (1) | CN1430600A (ru) |
AR (1) | AR033361A1 (ru) |
AT (1) | ATE365710T1 (ru) |
AU (1) | AU2001251157A1 (ru) |
BR (1) | BR0109725A (ru) |
CA (1) | CA2404628A1 (ru) |
CZ (1) | CZ20023581A3 (ru) |
DE (1) | DE60129116T2 (ru) |
EA (1) | EA200201046A1 (ru) |
ES (1) | ES2288945T3 (ru) |
HU (1) | HUP0300082A2 (ru) |
IL (1) | IL151971A0 (ru) |
MX (1) | MXPA02009482A (ru) |
WO (1) | WO2001074761A1 (ru) |
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AU3105801A (en) * | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
KR20030007489A (ko) | 2000-03-31 | 2003-01-23 | 트러스티즈 오브 터프츠 칼리지 | 7- 및 9-카르바메이트, 우레아, 티오우레아,티오카르바메이트 및 헤테로아릴-아미노 치환된테트라사이클린 화합물 |
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-
2001
- 2001-03-30 KR KR1020027013014A patent/KR20030007489A/ko not_active Application Discontinuation
- 2001-03-30 DE DE60129116T patent/DE60129116T2/de not_active Expired - Lifetime
- 2001-03-30 EA EA200201046A patent/EA200201046A1/ru unknown
- 2001-03-30 US US09/823,884 patent/US6818634B2/en not_active Expired - Lifetime
- 2001-03-30 WO PCT/US2001/010342 patent/WO2001074761A1/en active Search and Examination
- 2001-03-30 AR ARP010101560A patent/AR033361A1/es unknown
- 2001-03-30 EP EP01924508A patent/EP1272459B1/en not_active Expired - Lifetime
- 2001-03-30 JP JP2001572456A patent/JP2004505012A/ja not_active Ceased
- 2001-03-30 BR BR0109725-3A patent/BR0109725A/pt not_active IP Right Cessation
- 2001-03-30 CA CA002404628A patent/CA2404628A1/en not_active Abandoned
- 2001-03-30 IL IL15197101A patent/IL151971A0/xx unknown
- 2001-03-30 AT AT01924508T patent/ATE365710T1/de active
- 2001-03-30 AU AU2001251157A patent/AU2001251157A1/en not_active Abandoned
- 2001-03-30 ES ES01924508T patent/ES2288945T3/es not_active Expired - Lifetime
- 2001-03-30 CZ CZ20023581A patent/CZ20023581A3/cs unknown
- 2001-03-30 CN CN01810132A patent/CN1430600A/zh active Pending
- 2001-03-30 HU HU0300082A patent/HUP0300082A2/hu unknown
- 2001-03-30 MX MXPA02009482A patent/MXPA02009482A/es unknown
-
2004
- 2004-02-24 US US10/786,710 patent/US7858600B2/en not_active Expired - Fee Related
-
2010
- 2010-12-22 US US12/976,782 patent/US20110092467A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1272459B1 (en) | 2007-06-27 |
IL151971A0 (en) | 2003-04-10 |
US7858600B2 (en) | 2010-12-28 |
US20110092467A1 (en) | 2011-04-21 |
ATE365710T1 (de) | 2007-07-15 |
CN1430600A (zh) | 2003-07-16 |
MXPA02009482A (es) | 2004-05-14 |
AR033361A1 (es) | 2003-12-17 |
US20020103171A1 (en) | 2002-08-01 |
CA2404628A1 (en) | 2001-10-11 |
DE60129116D1 (en) | 2007-08-09 |
BR0109725A (pt) | 2003-02-04 |
HUP0300082A2 (en) | 2003-05-28 |
WO2001074761A1 (en) | 2001-10-11 |
US6818634B2 (en) | 2004-11-16 |
AU2001251157A1 (en) | 2001-10-15 |
DE60129116T2 (de) | 2008-03-13 |
JP2004505012A (ja) | 2004-02-19 |
EP1272459A1 (en) | 2003-01-08 |
CZ20023581A3 (cs) | 2003-04-16 |
ES2288945T3 (es) | 2008-02-01 |
US20040176334A1 (en) | 2004-09-09 |
KR20030007489A (ko) | 2003-01-23 |
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