EA200501046A1 - Эсциталопрамгидробромид и способ его получения - Google Patents

Эсциталопрамгидробромид и способ его получения

Info

Publication number
EA200501046A1
EA200501046A1 EA200501046A EA200501046A EA200501046A1 EA 200501046 A1 EA200501046 A1 EA 200501046A1 EA 200501046 A EA200501046 A EA 200501046A EA 200501046 A EA200501046 A EA 200501046A EA 200501046 A1 EA200501046 A1 EA 200501046A1
Authority
EA
Eurasian Patent Office
Prior art keywords
escitalopramhydrobromid
way
escitalopram
citalopram
hydrobromide
Prior art date
Application number
EA200501046A
Other languages
English (en)
Other versions
EA013116B1 (ru
Inventor
Лоренс Мартел
Роберт Дансер
Ханс Петерсен
Петер Эллегор
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32668635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200501046(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200501046A1 publication Critical patent/EA200501046A1/ru
Publication of EA013116B1 publication Critical patent/EA013116B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Эсциталопрам (S-циталопрам) в форме гидробромида, способы получения указанного соединения и содержащие эсциталопрам фармацевтические композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501046A 2002-12-23 2003-12-18 Эсциталопрамгидробромид, его применение и фармкомпозиция EA013116B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200202005 2002-12-23
PCT/DK2003/000902 WO2004056791A1 (en) 2002-12-23 2003-12-18 Escitalopram hydrobromide and a method for the preparation thereof

Publications (2)

Publication Number Publication Date
EA200501046A1 true EA200501046A1 (ru) 2005-12-29
EA013116B1 EA013116B1 (ru) 2010-02-26

Family

ID=32668635

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501046A EA013116B1 (ru) 2002-12-23 2003-12-18 Эсциталопрамгидробромид, его применение и фармкомпозиция

Country Status (33)

Country Link
US (1) US20040167209A1 (ru)
EP (1) EP1578738B1 (ru)
JP (2) JP4658613B2 (ru)
KR (1) KR20050086933A (ru)
CN (1) CN100349885C (ru)
AR (1) AR042652A1 (ru)
AT (1) ATE388947T1 (ru)
AU (1) AU2003287919B2 (ru)
BR (1) BR0317623A (ru)
CA (1) CA2511142A1 (ru)
CY (1) CY1107451T1 (ru)
DE (1) DE60319739T2 (ru)
DK (1) DK1578738T3 (ru)
EA (1) EA013116B1 (ru)
EG (1) EG24729A (ru)
ES (1) ES2298595T3 (ru)
HK (1) HK1087708A1 (ru)
IL (1) IL169125A0 (ru)
IS (1) IS2654B (ru)
ME (1) MEP5808A (ru)
MX (1) MXPA05005772A (ru)
MY (1) MY135468A (ru)
NO (1) NO20053595L (ru)
NZ (1) NZ540281A (ru)
PE (1) PE20040924A1 (ru)
PL (1) PL378275A1 (ru)
PT (1) PT1578738E (ru)
RS (1) RS51092B (ru)
TW (1) TW200501943A (ru)
UA (1) UA80170C2 (ru)
UY (1) UY28148A1 (ru)
WO (1) WO2004056791A1 (ru)
ZA (1) ZA200504109B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE388947T1 (de) * 2002-12-23 2008-03-15 Lundbeck & Co As H Escitalopramhydrobromid und ein verfahren zu dessen herstellung
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
EP1732514A1 (en) * 2004-03-05 2006-12-20 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
AU2006304889A1 (en) * 2005-10-14 2007-04-26 H. Lundbeck A/S Stable pharmaceutical formulations containing escitalopram and bupropion
JP2009511606A (ja) * 2005-10-14 2009-03-19 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムおよびブプロピオンの低用量の併用を用いる中枢神経系障害の治療方法
TW200812993A (en) * 2006-05-02 2008-03-16 Lundbeck & Co As H New uses of escitalopram
WO2008007691A1 (fr) * 2006-07-11 2008-01-17 Mitsubishi Tanabe Pharma Corporation Sels de composé de morpholine
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
FR3006594A1 (fr) * 2013-06-11 2014-12-12 Sorin Crm Sas Microsonde implantable de detection/stimulation incorporant un agent anti-inflammatoire
CN108976188B (zh) * 2017-06-05 2022-12-06 上海奥博生物医药股份有限公司 一种艾司西酞普兰双羟萘酸盐新的制备方法
KR102505669B1 (ko) 2017-10-09 2023-03-03 428 파마 비브이 에스시탈로프람의 새로운 염 및 고상형
US20240100012A1 (en) 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34712A (en) * 1862-03-18 James h
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
BR9915158B1 (pt) * 1998-10-20 2012-02-22 método para preparação de citalopram, e, compostos da fórmula geral viii, ix e iv, ou qualquer de seus enantiÈmeros e sais com adição de ácido do mesmo.
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
TR200401456T1 (tr) * 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
JP2002020379A (ja) * 2000-05-02 2002-01-23 Sumika Fine Chemicals Co Ltd シタロプラム臭化水素酸塩の結晶およびその結晶化方法
CA2353693C (en) * 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
PL198771B1 (pl) * 2000-12-04 2008-07-31 Westfalia Separator Ag Sposób wytwarzania estrów kwasów tłuszczowych
CN1509169A (zh) * 2001-05-01 2004-06-30 H��¡�±������޹�˾ 对映体纯艾司西酞普兰的用途
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
ATE388947T1 (de) * 2002-12-23 2008-03-15 Lundbeck & Co As H Escitalopramhydrobromid und ein verfahren zu dessen herstellung
US20050174782A1 (en) * 2003-03-25 2005-08-11 Chapman Leonard T. Flashlight

Also Published As

Publication number Publication date
EP1578738A1 (en) 2005-09-28
DK1578738T3 (da) 2008-06-30
ATE388947T1 (de) 2008-03-15
CN1726202A (zh) 2006-01-25
DE60319739D1 (de) 2008-04-24
TW200501943A (en) 2005-01-16
KR20050086933A (ko) 2005-08-30
IS2654B (is) 2010-08-15
PL378275A1 (pl) 2006-03-20
MEP5808A (xx) 2010-02-10
PT1578738E (pt) 2008-04-11
UY28148A1 (es) 2004-09-30
IS7848A (is) 2005-05-17
BR0317623A (pt) 2005-11-29
AU2003287919B2 (en) 2009-11-12
MY135468A (en) 2008-04-30
WO2004056791A1 (en) 2004-07-08
PE20040924A1 (es) 2004-12-11
AU2003287919A1 (en) 2004-07-14
CY1107451T1 (el) 2012-12-19
MXPA05005772A (es) 2005-08-16
US20040167209A1 (en) 2004-08-26
EG24729A (en) 2010-06-21
EP1578738B1 (en) 2008-03-12
ES2298595T3 (es) 2008-05-16
IL169125A0 (en) 2009-02-11
ZA200504109B (en) 2006-08-30
NO20053595L (no) 2005-09-05
HK1087708A1 (en) 2006-10-20
UA80170C2 (en) 2007-08-27
CN100349885C (zh) 2007-11-21
JP2006514952A (ja) 2006-05-18
CA2511142A1 (en) 2004-07-08
DE60319739T2 (de) 2008-07-17
NZ540281A (en) 2008-07-31
RS20050487A (en) 2007-06-04
RS51092B (sr) 2010-10-31
AR042652A1 (es) 2005-06-29
EA013116B1 (ru) 2010-02-26
JP4658613B2 (ja) 2011-03-23
JP2011037893A (ja) 2011-02-24

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU