ATE433458T1 - Modulatoren von ship-1 - Google Patents

Modulatoren von ship-1

Info

Publication number
ATE433458T1
ATE433458T1 AT03714589T AT03714589T ATE433458T1 AT E433458 T1 ATE433458 T1 AT E433458T1 AT 03714589 T AT03714589 T AT 03714589T AT 03714589 T AT03714589 T AT 03714589T AT E433458 T1 ATE433458 T1 AT E433458T1
Authority
AT
Austria
Prior art keywords
ship
modulators
activity
pelorol
synthesis
Prior art date
Application number
AT03714589T
Other languages
English (en)
Inventor
Raymond Andersen
David Williams
Alice Mui
Christopher Ong
Gerald Krystal
Lu Yang
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2002/001550 external-priority patent/WO2003033517A1/en
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of ATE433458T1 publication Critical patent/ATE433458T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Amplitude Modulation (AREA)
AT03714589T 2002-10-17 2003-04-23 Modulatoren von ship-1 ATE433458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CA2002/001550 WO2003033517A1 (en) 2001-10-17 2002-10-17 Ship 1 modulators
PCT/CA2003/000571 WO2004035601A1 (en) 2002-10-17 2003-04-23 Ship 1 modulators

Publications (1)

Publication Number Publication Date
ATE433458T1 true ATE433458T1 (de) 2009-06-15

Family

ID=32097361

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03714589T ATE433458T1 (de) 2002-10-17 2003-04-23 Modulatoren von ship-1

Country Status (7)

Country Link
EP (1) EP1554304B1 (de)
JP (1) JP4753581B2 (de)
AT (1) ATE433458T1 (de)
CA (1) CA2502293C (de)
DE (1) DE60327936D1 (de)
ES (1) ES2327829T3 (de)
WO (1) WO2004035601A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2656339A1 (en) * 2006-06-21 2007-12-27 The University Of British Columbia Ship 1 modulator prodrugs
WO2011069118A1 (en) 2009-12-04 2011-06-09 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
CN105853348B (zh) 2011-03-10 2019-08-30 Xeris药物公司 肠胃外注射用稳定溶液
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
HK1216886A1 (zh) 2013-01-09 2016-12-09 Aquinox Pharmaceuticals (Canada) Inc. Ship1调节剂和与其相关的方法
EP2970122B1 (de) 2013-03-14 2019-05-08 Aquinox Pharmaceuticals (Canada) Inc. Ship1-modulatoren
BR112015022577A2 (pt) 2013-03-14 2017-07-18 Aquinox Pharmaceuticals Canada Inc moduladores ship1 e métodos relacionados a esse
AU2015300944B2 (en) 2014-08-06 2019-07-11 Xeris Pharmaceuticals, Inc. Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
US9944590B2 (en) 2015-06-26 2018-04-17 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
WO2017127753A1 (en) 2016-01-20 2017-07-27 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
BR112019024987A2 (pt) 2017-06-02 2020-06-16 Xeris Pharmaceuticals, Inc. Formulações de fármaco de molécula pequena resistente à precipitação
EP4143202A4 (de) * 2020-04-20 2024-04-24 ZebraPeutics Inc. Verfahren zur behandlung von ship1-vermittelten erkrankungen mit pelorolderivaten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033517A1 (en) * 2001-10-17 2003-04-24 The University Of British Columbia Ship 1 modulators

Also Published As

Publication number Publication date
ES2327829T3 (es) 2009-11-04
CA2502293C (en) 2011-09-06
CA2502293A1 (en) 2004-04-29
DE60327936D1 (de) 2009-07-23
EP1554304B1 (de) 2009-06-10
WO2004035601A1 (en) 2004-04-29
JP4753581B2 (ja) 2011-08-24
EP1554304A1 (de) 2005-07-20
JP2006506363A (ja) 2006-02-23

Similar Documents

Publication Publication Date Title
HRP20080564T3 (hr) Dihidrotetrabenazini i farmaceutski pripravci koji ih sadrže
SE0301653D0 (sv) Novel compounds
DE60327936D1 (de) Modulatoren von ship-1
ATE433447T1 (de) Pyrimiidinverbindungen
BR0317715A (pt) Composições e processos de uso de collajolie
ATE455092T1 (de) Substituierte tetracyclin-verbindungen zur behandlung von malaria
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
ATE369755T1 (de) Verwendung von diphenylmethan-derivaten als tyrosinase-inhibitoren
DE602004012083D1 (de) Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren
MA28985B1 (fr) Analogues de loxapine et methodes d'utilisation
ATE396993T1 (de) Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
ES2173480T3 (es) Preparacion de derivados de ciclohexeno carboxilato.
AU2003228770A1 (en) Substituted pyrazolopyrimidines
ATE335748T1 (de) Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen
TR199901191T2 (xx) Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
BG99177A (bg) Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза
BR0300709A (pt) Sal de perindopril e as composições farmacêuticas contendo o mesmo
IL151172A0 (en) Amine derivatives, their preparation and use as bax modulators
MXPA03010158A (es) Sulfonamidas.
DE60301339D1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
AUPR118000A0 (en) Therapeutic molecules and methods
PA8577701A1 (es) Polipeptido t20 pegilado
DK1383742T3 (da) Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater
AR020563A1 (es) Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
SE9903290D0 (sv) Novel compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties