ATE433458T1 - Modulatoren von ship-1 - Google Patents

Modulatoren von ship-1

Info

Publication number
ATE433458T1
ATE433458T1 AT03714589T AT03714589T ATE433458T1 AT E433458 T1 ATE433458 T1 AT E433458T1 AT 03714589 T AT03714589 T AT 03714589T AT 03714589 T AT03714589 T AT 03714589T AT E433458 T1 ATE433458 T1 AT E433458T1
Authority
AT
Austria
Prior art keywords
ship
modulators
activity
pelorol
synthesis
Prior art date
Application number
AT03714589T
Other languages
English (en)
Inventor
Raymond Andersen
David Williams
Alice Mui
Christopher Ong
Gerald Krystal
Lu Yang
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2002/001550 external-priority patent/WO2003033517A1/en
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of ATE433458T1 publication Critical patent/ATE433458T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Amplitude Modulation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03714589T 2002-10-17 2003-04-23 Modulatoren von ship-1 ATE433458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CA2002/001550 WO2003033517A1 (en) 2001-10-17 2002-10-17 Ship 1 modulators
PCT/CA2003/000571 WO2004035601A1 (en) 2002-10-17 2003-04-23 Ship 1 modulators

Publications (1)

Publication Number Publication Date
ATE433458T1 true ATE433458T1 (de) 2009-06-15

Family

ID=32097361

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03714589T ATE433458T1 (de) 2002-10-17 2003-04-23 Modulatoren von ship-1

Country Status (7)

Country Link
EP (1) EP1554304B1 (de)
JP (1) JP4753581B2 (de)
AT (1) ATE433458T1 (de)
CA (1) CA2502293C (de)
DE (1) DE60327936D1 (de)
ES (1) ES2327829T3 (de)
WO (1) WO2004035601A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2035367A1 (de) * 2006-06-21 2009-03-18 The University of British Columbia Ship-1-modulatorprodrugs
WO2011069118A1 (en) 2009-12-04 2011-06-09 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
SG193389A1 (en) 2011-03-10 2013-10-30 Xeris Pharmaceuticals Inc Stable formulations for parenteral injection of peptide drugs
US9125805B2 (en) * 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
CN108752236A (zh) 2013-01-09 2018-11-06 阿奎诺克斯药物（加拿大）公司 Ship1调节剂和与其相关的方法
WO2014143561A1 (en) 2013-03-14 2014-09-18 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
US9765085B2 (en) 2013-03-14 2017-09-19 Aquinox Pharmaceuticals (Canada) Inc. SHIP1 modulators and methods related thereto
JP6982495B2 (ja) 2014-08-06 2021-12-17 ゼリス ファーマシューティカルズ インコーポレイテッド ペーストの皮内および／または皮下注射のためのシリンジ、キット、および方法
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
WO2016210146A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
AU2017209430A1 (en) 2016-01-20 2018-07-12 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
US11020403B2 (en) 2017-06-02 2021-06-01 Xeris Pharmaceuticals, Inc. Precipitation resistant small molecule drug formulations
WO2021213393A1 (en) * 2020-04-20 2021-10-28 Zebrapeutics Inc. Method of treating ship1-mediated diseases using pelorol derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033517A1 (en) * 2001-10-17 2003-04-24 The University Of British Columbia Ship 1 modulators

Also Published As

Publication number Publication date
CA2502293C (en) 2011-09-06
EP1554304A1 (de) 2005-07-20
JP2006506363A (ja) 2006-02-23
ES2327829T3 (es) 2009-11-04
WO2004035601A1 (en) 2004-04-29
DE60327936D1 (de) 2009-07-23
CA2502293A1 (en) 2004-04-29
EP1554304B1 (de) 2009-06-10
JP4753581B2 (ja) 2011-08-24

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Legal Events

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