DK1383742T3 - Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater - Google Patents

Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater

Info

Publication number
DK1383742T3
DK1383742T3 DK02725584.3T DK02725584T DK1383742T3 DK 1383742 T3 DK1383742 T3 DK 1383742T3 DK 02725584 T DK02725584 T DK 02725584T DK 1383742 T3 DK1383742 T3 DK 1383742T3
Authority
DK
Denmark
Prior art keywords
methods
tetrahydroindolone
derivatives
analogs
synthesis
Prior art date
Application number
DK02725584.3T
Other languages
English (en)
Inventor
David B Fick
Mark M Foreman
Alvin J Glasky
Original Assignee
Spectrum Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrum Pharmaceuticals Inc filed Critical Spectrum Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1383742T3 publication Critical patent/DK1383742T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DK02725584.3T 2001-04-20 2002-04-08 Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater DK1383742T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/839,289 US6759427B2 (en) 2001-04-20 2001-04-20 Synthesis and methods of use of tetrahydroindolone analogues and derivatives
PCT/US2002/011142 WO2002085856A1 (en) 2001-04-20 2002-04-08 Synthesis and methods of use of tetrahydroindolone analogues and derivatives

Publications (1)

Publication Number Publication Date
DK1383742T3 true DK1383742T3 (da) 2011-02-14

Family

ID=25279337

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02725584.3T DK1383742T3 (da) 2001-04-20 2002-04-08 Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater

Country Status (7)

Country Link
US (6) US6759427B2 (da)
EP (1) EP1383742B1 (da)
AT (1) ATE486059T1 (da)
DE (1) DE60238113D1 (da)
DK (1) DK1383742T3 (da)
ES (1) ES2385932T3 (da)
WO (1) WO2002085856A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
WO2005030148A2 (en) * 2003-09-25 2005-04-07 Cenomed, Inc. Tetrahydroindolone derivatives for treatment of neurological conditions
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
WO2006133634A1 (fr) * 2005-06-14 2006-12-21 Beijing Gylongly Biodemtech Co., Ltd Dérivés tétrahydroindole et dérivés tétrahydroindazole et leur utilisation
CA2642931A1 (en) * 2006-02-27 2007-09-07 Serenex, Inc. Cyclohexylamino, benzene, pyridine, and pyridazine derivatives
KR101742179B1 (ko) 2006-10-12 2017-05-31 비에이치아이 리미티드 파트너쉽 3-아미노-1-프로판설폰산을 전달하기 위한 방법, 화합물, 조성물 및 비히클
EP2219648A4 (en) * 2007-11-09 2010-11-03 Cenomed Biosciences Llc TREATMENT OF POSTRAUMATIC STRESS WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
KR20120036813A (ko) * 2009-05-29 2012-04-18 아스텔라스세이야쿠 가부시키가이샤 주의 결함/다동성 장애 예방용 및/또는 치료용 신규 의약 조성물
RU2503452C2 (ru) * 2011-11-24 2014-01-10 Общество С Ограниченной Ответственностью "Консорциум-Пик" Фармацевтическая композиция на основе растительной докозагексаеновой кислоты для профилактики синдрома гиперактивности у детей
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
EP3446118B1 (en) 2016-04-22 2024-01-24 Becton, Dickinson and Company Multiplex polymeric dye devices and methods for using the same
US11320437B2 (en) 2017-02-08 2022-05-03 Becton, Dickinson And Company Dried dye reagent devices and methods for making and using the same
EP4085056A1 (en) 2020-01-03 2022-11-09 Berg LLC Polycyclic amides as ube2k modulators for treating cancer

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300380A (en) * 1963-12-26 1967-01-24 Upjohn Co Diminishing toxicity of antiviral nu6-(hydroxyalkyl) adenines with 4-hydroxypyrazolo(3, 4-d) pyrimidine
US3321369A (en) * 1965-05-26 1967-05-23 Abbott Lab Method of enhancing learning rate and retention level in warm blooded animals
US3484521A (en) * 1966-06-23 1969-12-16 Int Chem & Nuclear Corp Enhancement of memory processes in mammals with basic addition salts of ribonucleic acid
BE759011A (fr) * 1969-11-17 1971-05-17 Wellcome Found Aminopurines
DE2554453A1 (de) * 1974-12-18 1976-06-24 Experimentales Et Cliniques De Medikament zur glykaemieregulierung
GB1530912A (en) * 1975-02-13 1978-11-01 Wellcome Found Compositions containing 9-(2-hydroxy-3-alkyl)-adenines
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4221909A (en) * 1978-09-15 1980-09-09 Sloan-Kettering Institute For Cancer Research P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4340726A (en) * 1980-03-14 1982-07-20 Newport Pharmaceuticals International, Inc. Esters
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
US4977178A (en) * 1982-09-20 1990-12-11 Pfizer Inc. Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
US4643992A (en) * 1982-11-09 1987-02-17 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5093318A (en) * 1983-11-01 1992-03-03 Scripps Clinic And Research Foundation Immunostimulating guanosine derivatives and their pharmaceutical compositions
US4952693A (en) * 1984-10-12 1990-08-28 Warner-Lambert Company Oxazolo-pyrimidine derivatives
JPH0696534B2 (ja) * 1986-04-25 1994-11-30 ヘキストジヤパン株式会社 抗痴呆剤
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
EP0338169B1 (en) 1988-04-19 1996-07-24 Institut Pasteur Method for obtaining protective antigens against bordetella infections and toxic processes
US5256677A (en) * 1989-05-23 1993-10-26 Abbott Laboratories Retroviral protease inhibiting compounds
US5187162A (en) * 1989-09-15 1993-02-16 Gensia Pharmaceuticals Methods of treating neurodegenerative conditions
US5026687A (en) * 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
US5091432A (en) * 1990-03-28 1992-02-25 Glasky Alvin J 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
US5237051A (en) * 1990-12-06 1993-08-17 Vanderbilt University Purified enterotoxin receptor protein
US5319096A (en) 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5801184A (en) * 1994-07-25 1998-09-01 Glasky; Alvin J. Carbon monoxide dependent guanylyl cyclase modifiers and methods of use
US5447939A (en) * 1994-07-25 1995-09-05 Glasky; Alvin J. Carbon monoxide dependent guanylyl cyclase modifiers and methods of use
US5644568A (en) * 1995-03-15 1997-07-01 Motorola, Inc. Method and apparatus for organizing and recovering information communicated in a radio communication system
FR2736640B1 (fr) * 1995-07-13 1997-08-22 Oreal Compositions de teinture des fibres keratiniques contenant des derives n-substitues du 4-hydroxy indole, nouveaux derives, leur procede de synthese, leur utilisation pour la teinture, et procede de teinture
JP2842816B2 (ja) * 1995-10-16 1999-01-06 日本電気アイシーマイコンシステム株式会社 半導体記憶装置
US5795756A (en) 1995-12-11 1998-08-18 Johnson; Roger A. Method and compounds for the inhibition of adenylyl cyclase
US5948771A (en) * 1996-01-31 1999-09-07 The Trustees Of Columbia University In The City Of New York Method for treating heart failure using tetrapyrroles and metallotetrapyrroles
US5801159A (en) * 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
AU3785799A (en) 1998-05-04 1999-11-23 Neotherapeutics, Inc. Method for treating migraine in mammals
WO1999057120A1 (en) 1998-05-04 1999-11-11 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
AU3879899A (en) 1998-05-04 1999-11-23 Neotherapeutics, Inc. Novel dopamine-like 9-substituted hypoxanthine and methods of use
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US20020040031A1 (en) * 2000-07-07 2002-04-04 Glasky Michelle S. Methods for prevention of accumulation of amyloid beta peptide in the central nervous system
US20020040032A1 (en) * 2000-07-07 2002-04-04 Glasky Michelle S. Methods for stimulation of synthesis of synaptophysin in the central nervous system
US6630478B2 (en) 2000-07-07 2003-10-07 Neotherapeutics, Inc. Methods for treatment of drug-induced peripheral neuropathy
US20020128264A1 (en) * 2000-07-07 2002-09-12 Taylor Eve M. Methods for treatment of conditions affected by activity of multidrug transporters
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US6770638B2 (en) * 2001-04-20 2004-08-03 Spectrum Pharmaceuticals, Inc. Tetrahydroindolone and purine derivatives linked to arylpiperazines
WO2005030148A2 (en) * 2003-09-25 2005-04-07 Cenomed, Inc. Tetrahydroindolone derivatives for treatment of neurological conditions

Also Published As

Publication number Publication date
EP1383742A1 (en) 2004-01-28
DE60238113D1 (de) 2010-12-09
US7531670B2 (en) 2009-05-12
US6982269B2 (en) 2006-01-03
US20120070385A1 (en) 2012-03-22
ATE486059T1 (de) 2010-11-15
US8734818B2 (en) 2014-05-27
US20020198218A1 (en) 2002-12-26
ES2385932T3 (es) 2012-08-03
US8063233B2 (en) 2011-11-22
US20130225648A1 (en) 2013-08-29
US6759427B2 (en) 2004-07-06
WO2002085856A1 (en) 2002-10-31
EP1383742B1 (en) 2010-10-27
US20030022892A1 (en) 2003-01-30
US20050096317A1 (en) 2005-05-05
US20090192319A1 (en) 2009-07-30
US8377456B2 (en) 2013-02-19

Similar Documents

Publication Publication Date Title
SG149063A1 (en) Use of modified cyclosporins for the treatment of hcv disorders
ATE455092T1 (de) Substituierte tetracyclin-verbindungen zur behandlung von malaria
DK1383742T3 (da) Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater
DK1459750T3 (da) (S,S)-rebexetin til behandling af fibromyalgi og andre somatoforme lidelser
DE60325025D1 (de) Modulatoren des vanilloidrezeptors
DK1259512T3 (da) Pteridinforbindelser til behandling af psoreasis
DK2308507T3 (da) Fremgangsmåder til behandling af præeklampsi
DK1562932T3 (da) 4 tetrazolyl-4-phenylpiperidinderivater til behandling af smerter
DK1404324T3 (da) Prolægemidler af GABA analoger, sammensætninger og anvendelser deraf
ATE451921T1 (de) Phenylindole zur behandlung von hiv
DK1147083T3 (da) Arylpiperazinyl-cyclohexylindolderivater til behandling af depression
NO20050091L (no) Fremgangsmater for fremstilling av fibrinogen
DK1450606T3 (da) Synergistiske sammensætninger til behandling af såsæd
DK1448205T3 (da) Kombinationer til behandling af immunoinflammatoriske sygdomme
DK1097173T3 (da) Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
DK1491212T3 (da) Middel til behandling af søvnforstyrrelser
DK1456212T3 (da) 6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse
DK1578740T3 (da) 1,2,4-triaminobenzenderivater, der er egnede til behandling af lidelser i centralnervesystemet
DK1206436T3 (da) Retinoider til behandling af emfysem
DK1680430T3 (da) Fremgangsmåder til fremstilling af form I af (S)-(+)-Clopidogrel-bisulfat
DK1492501T3 (da) Fremgangsmåder med anvendelse af lamellare legemer til terapeutiske formål
DK1268482T3 (da) Pyranoindoler til behandling af glaukom
ITGE20020050A0 (it) Procedimento per il trattamento di filati mediante agugliatura.
MXPA04000272A (es) Derivados de 4-aminociclohexanol sustituidos.
DK1503995T3 (da) Fremgangsmåde til fremstilling af substituerede phenylsulfonylurinstoffer