ES2173876T3 - Nuevas 7-(sustituido)-8-(sustituido)-9-(amino sustituido)-6-desmetil-desoxitetraciclinas como agentes antibioticos. - Google Patents

Nuevas 7-(sustituido)-8-(sustituido)-9-(amino sustituido)-6-desmetil-desoxitetraciclinas como agentes antibioticos.

Info

Publication number
ES2173876T3
ES2173876T3 ES93109850T ES93109850T ES2173876T3 ES 2173876 T3 ES2173876 T3 ES 2173876T3 ES 93109850 T ES93109850 T ES 93109850T ES 93109850 T ES93109850 T ES 93109850T ES 2173876 T3 ES2173876 T3 ES 2173876T3
Authority
ES
Spain
Prior art keywords
replaced
detoxitethyclines
demet
new
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93109850T
Other languages
English (en)
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Raymond T Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2173876T3 publication Critical patent/ES2173876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

LA INVENCION PRESENTA COMPUESTOS DE LA FORMULA I: EN DONDE X, R Y R'' QUEDAN DEFINIDOS EN LA ESPECIFICACION. ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIBIOTICOS.
ES93109850T 1992-08-13 1993-06-21 Nuevas 7-(sustituido)-8-(sustituido)-9-(amino sustituido)-6-desmetil-desoxitetraciclinas como agentes antibioticos. Expired - Lifetime ES2173876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (1)

Publication Number Publication Date
ES2173876T3 true ES2173876T3 (es) 2002-11-01

Family

ID=25456505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93109850T Expired - Lifetime ES2173876T3 (es) 1992-08-13 1993-06-21 Nuevas 7-(sustituido)-8-(sustituido)-9-(amino sustituido)-6-desmetil-desoxitetraciclinas como agentes antibioticos.

Country Status (24)

Country Link
US (4) US5430162A (es)
EP (1) EP0582810B1 (es)
JP (1) JP3639313B2 (es)
KR (1) KR100309540B1 (es)
CN (1) CN1048719C (es)
AT (1) ATE215530T1 (es)
AU (1) AU674524B2 (es)
CA (1) CA2103861C (es)
CZ (1) CZ289195B6 (es)
DE (1) DE69331774T2 (es)
DK (1) DK0582810T3 (es)
ES (1) ES2173876T3 (es)
FI (1) FI933567A (es)
HU (2) HU213269B (es)
IL (4) IL106677A (es)
NO (1) NO302568B1 (es)
NZ (1) NZ248359A (es)
PH (1) PH31210A (es)
PL (4) PL174127B1 (es)
PT (1) PT582810E (es)
RU (1) RU2127255C1 (es)
SG (1) SG47520A1 (es)
SK (1) SK281871B6 (es)
ZA (1) ZA935892B (es)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
CA2672722C (en) * 1999-09-14 2013-11-05 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CN1430600A (zh) * 2000-03-31 2003-07-16 塔夫茨大学信托人 7－和9－氨基甲酸酯、脲、硫脲、硫代氨基甲酸酯,和杂芳基－氨基取代的四环素化合物
EP1296703B1 (en) * 2000-06-02 2005-02-09 Yu Liu Non-antibacterial tetracycline as anti-fungal agents
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
KR100674047B1 (ko) * 2000-07-07 2007-01-25 트러스티즈 오브 터프츠 칼리지 9-치환된 미노사이클린 화합물
US6818635B2 (en) * 2000-07-07 2004-11-16 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
ATE504562T1 (de) * 2000-07-07 2011-04-15 Tufts College 7-, 8- und 9-substitutierte tetracyclinverbindungen
IL157860A0 (en) 2001-03-13 2004-03-28 Paratek Pharm Innc 7,9-substituted tetracycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
ATE455092T1 (de) * 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2301915A1 (en) 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7-(diethylamino)methyl substituted tetracycline having target therapeutic activities
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN102531948A (zh) * 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2003243205A1 (en) * 2002-05-06 2003-11-17 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
WO2004000223A2 (en) * 2002-06-20 2003-12-31 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
EP1534300A4 (en) 2002-07-12 2008-04-23 Paratek Pharm Innc TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A
JP2006503898A (ja) * 2002-10-24 2006-02-02 パラテック ファーマシューティカルズ， インク． マラリア治療のための置換テトラサイクリン化合物
EP2298323A3 (en) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP1716101A1 (en) * 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
AU2005244988C1 (en) 2004-05-21 2012-06-28 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284150A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
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Also Published As

Publication number Publication date
NO932872D0 (no) 1993-08-12
ZA935892B (en) 1994-03-10
RU2127255C1 (ru) 1999-03-10
CA2103861C (en) 2004-07-27
DE69331774T2 (de) 2002-11-14
CN1090267A (zh) 1994-08-03
IL119750A0 (en) 1997-03-18
US5495018A (en) 1996-02-27
IL119751A (en) 1998-09-24
EP0582810A1 (en) 1994-02-16
HU213269B (en) 1997-04-28
FI933567A (fi) 1994-02-14
IL106677A0 (en) 1993-12-08
HU9302333D0 (en) 1993-10-28
SK281871B6 (sk) 2001-08-06
JP3639313B2 (ja) 2005-04-20
IL119750A (en) 1998-09-24
PL300066A1 (en) 1994-02-21
CA2103861A1 (en) 1994-02-14
PT582810E (pt) 2002-08-30
HUT64945A (en) 1994-03-28
CZ289195B6 (cs) 2001-11-14
DK0582810T3 (da) 2002-06-03
ATE215530T1 (de) 2002-04-15
EP0582810B1 (en) 2002-04-03
PH31210A (en) 1998-05-05
IL106677A (en) 1998-06-15
CZ157593A3 (en) 1994-02-16
PL174022B1 (pl) 1998-06-30
KR100309540B1 (ko) 2002-04-24
NZ248359A (en) 1996-03-26
SG47520A1 (en) 1998-04-17
US5430162A (en) 1995-07-04
PL174127B1 (pl) 1998-06-30
JPH06228072A (ja) 1994-08-16
HU211303A9 (en) 1995-11-28
US5512553A (en) 1996-04-30
US5886175A (en) 1999-03-23
DE69331774D1 (de) 2002-05-08
FI933567A0 (fi) 1993-08-12
CN1048719C (zh) 2000-01-26
PL175487B1 (pl) 1999-01-29
AU4460193A (en) 1994-02-17
SK85793A3 (en) 1994-04-06
NO932872L (no) 1994-02-14
AU674524B2 (en) 1997-01-02
KR940003925A (ko) 1994-03-14
PL174230B1 (pl) 1998-07-31
NO302568B1 (no) 1998-03-23

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