ATE215530T1 - 7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel - Google Patents

7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel

Info

Publication number
ATE215530T1
ATE215530T1 AT93109850T AT93109850T ATE215530T1 AT E215530 T1 ATE215530 T1 AT E215530T1 AT 93109850 T AT93109850 T AT 93109850T AT 93109850 T AT93109850 T AT 93109850T AT E215530 T1 ATE215530 T1 AT E215530T1
Authority
AT
Austria
Prior art keywords
substituted
demethyl
deoxy
tetracycline
antibiotic agents
Prior art date
Application number
AT93109850T
Other languages
English (en)
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Raymond T Testa
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE215530T1 publication Critical patent/ATE215530T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
AT93109850T 1992-08-13 1993-06-21 7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel ATE215530T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (1)

Publication Number Publication Date
ATE215530T1 true ATE215530T1 (de) 2002-04-15

Family

ID=25456505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93109850T ATE215530T1 (de) 1992-08-13 1993-06-21 7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel

Country Status (24)

Country Link
US (4) US5430162A (de)
EP (1) EP0582810B1 (de)
JP (1) JP3639313B2 (de)
KR (1) KR100309540B1 (de)
CN (1) CN1048719C (de)
AT (1) ATE215530T1 (de)
AU (1) AU674524B2 (de)
CA (1) CA2103861C (de)
CZ (1) CZ289195B6 (de)
DE (1) DE69331774T2 (de)
DK (1) DK0582810T3 (de)
ES (1) ES2173876T3 (de)
FI (1) FI933567A7 (de)
HU (2) HU213269B (de)
IL (4) IL106677A (de)
NO (1) NO302568B1 (de)
NZ (1) NZ248359A (de)
PH (1) PH31210A (de)
PL (4) PL174022B1 (de)
PT (1) PT582810E (de)
RU (1) RU2127255C1 (de)
SG (1) SG47520A1 (de)
SK (1) SK281871B6 (de)
ZA (1) ZA935892B (de)

Families Citing this family (62)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
EP1666454B1 (de) * 1999-09-14 2011-09-07 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Hilfe von auf Übergangsmetalle basierten Chemikalien
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
RU2154084C1 (ru) * 1999-11-09 2000-08-10 Открытое акционерное общество "ПермНИПИнефть" Реагент для обработки буровых растворов
DE60129116T2 (de) * 2000-03-31 2008-03-13 Trustees Of Tufts College, Medford 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
ATE288779T1 (de) * 2000-06-02 2005-02-15 Yu Liu Nicht-antibakterielle tetrazykline als anti-pilz medikamente
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EA201000496A1 (ru) * 2000-07-07 2010-10-29 Трастис Оф Тафтс Коллидж Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)
CZ2003343A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
EP1303479B1 (de) * 2000-07-07 2011-04-06 Trustees Of Tufts College 7-, 8- und 9-substitutierte tetracyclinverbindungen
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (de) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
HRP20030743A2 (en) 2001-03-13 2005-06-30 Paratek Pharmaceuticals 7,9-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
ATE455092T1 (de) * 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2332549A1 (de) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Neue Tetracyclinverbindungen und deren medizinischen Anwendung
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
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US7056902B2 (en) * 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP2316450A1 (de) * 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Aminomethyl-substituierte Tetracyclin-Verbindungen
KR101083498B1 (ko) 2002-03-21 2011-11-16 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
EP1501490A2 (de) * 2002-05-06 2005-02-02 Collagenex Pharmaceuticals, Inc. Verfahren zur gleichzeitigen behandlung von mucositis und pilzinfektionen
WO2004000223A2 (en) * 2002-06-20 2003-12-31 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
CN1700922A (zh) 2002-07-12 2005-11-23 帕拉特克药品公司 3、10或12a位取代的四环素化合物
JP2006503898A (ja) * 2002-10-24 2006-02-02 パラテック ファーマシューティカルズ， インク． マラリア治療のための置換テトラサイクリン化合物
CN1845897A (zh) * 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
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BRPI0510113B1 (pt) 2004-05-21 2022-09-27 President And Fellows Of Harvard College Compostos de tetraciclinas e análogos das mesmas
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Also Published As

Publication number Publication date
HU211303A9 (en) 1995-11-28
US5495018A (en) 1996-02-27
NO302568B1 (no) 1998-03-23
AU674524B2 (en) 1997-01-02
US5886175A (en) 1999-03-23
JP3639313B2 (ja) 2005-04-20
PH31210A (en) 1998-05-05
PL175487B1 (pl) 1999-01-29
PL300066A1 (en) 1994-02-21
IL106677A (en) 1998-06-15
EP0582810A1 (de) 1994-02-16
HUT64945A (en) 1994-03-28
CA2103861A1 (en) 1994-02-14
RU2127255C1 (ru) 1999-03-10
SG47520A1 (en) 1998-04-17
JPH06228072A (ja) 1994-08-16
CN1048719C (zh) 2000-01-26
SK85793A3 (en) 1994-04-06
KR100309540B1 (ko) 2002-04-24
HU9302333D0 (en) 1993-10-28
FI933567L (fi) 1994-02-14
IL106677A0 (en) 1993-12-08
NO932872D0 (no) 1993-08-12
FI933567A0 (fi) 1993-08-12
ZA935892B (en) 1994-03-10
PL174127B1 (pl) 1998-06-30
FI933567A7 (fi) 1994-02-14
NO932872L (no) 1994-02-14
DE69331774T2 (de) 2002-11-14
AU4460193A (en) 1994-02-17
IL119751A (en) 1998-09-24
CZ157593A3 (en) 1994-02-16
CA2103861C (en) 2004-07-27
DK0582810T3 (da) 2002-06-03
NZ248359A (en) 1996-03-26
KR940003925A (ko) 1994-03-14
CN1090267A (zh) 1994-08-03
ES2173876T3 (es) 2002-11-01
US5512553A (en) 1996-04-30
DE69331774D1 (de) 2002-05-08
IL119750A (en) 1998-09-24
PL174230B1 (pl) 1998-07-31
EP0582810B1 (de) 2002-04-03
SK281871B6 (sk) 2001-08-06
PL174022B1 (pl) 1998-06-30
CZ289195B6 (cs) 2001-11-14
PT582810E (pt) 2002-08-30
HU213269B (en) 1997-04-28
IL119750A0 (en) 1997-03-18
US5430162A (en) 1995-07-04

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