NO302568B1 - Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem - Google Patents
Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av demInfo
- Publication number
- NO302568B1 NO302568B1 NO932872A NO932872A NO302568B1 NO 302568 B1 NO302568 B1 NO 302568B1 NO 932872 A NO932872 A NO 932872A NO 932872 A NO932872 A NO 932872A NO 302568 B1 NO302568 B1 NO 302568B1
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- demethyl
- tetracyclines
- deoxy
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/20—Diazonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92859892A | 1992-08-13 | 1992-08-13 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO932872D0 NO932872D0 (no) | 1993-08-12 |
NO932872L NO932872L (no) | 1994-02-14 |
NO302568B1 true NO302568B1 (no) | 1998-03-23 |
Family
ID=25456505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO932872A NO302568B1 (no) | 1992-08-13 | 1993-08-12 | Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem |
Country Status (24)
Country | Link |
---|---|
US (4) | US5430162A (de) |
EP (1) | EP0582810B1 (de) |
JP (1) | JP3639313B2 (de) |
KR (1) | KR100309540B1 (de) |
CN (1) | CN1048719C (de) |
AT (1) | ATE215530T1 (de) |
AU (1) | AU674524B2 (de) |
CA (1) | CA2103861C (de) |
CZ (1) | CZ289195B6 (de) |
DE (1) | DE69331774T2 (de) |
DK (1) | DK0582810T3 (de) |
ES (1) | ES2173876T3 (de) |
FI (1) | FI933567A (de) |
HU (2) | HU213269B (de) |
IL (4) | IL119751A (de) |
NO (1) | NO302568B1 (de) |
NZ (1) | NZ248359A (de) |
PH (1) | PH31210A (de) |
PL (4) | PL174022B1 (de) |
PT (1) | PT582810E (de) |
RU (1) | RU2127255C1 (de) |
SG (1) | SG47520A1 (de) |
SK (1) | SK281871B6 (de) |
ZA (1) | ZA935892B (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
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USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
EP1666454B1 (de) * | 1999-09-14 | 2011-09-07 | Trustees Of Tufts College | Verfahren zur Herstellung von substituierten Tetracyclinen mit Hilfe von auf Übergangsmetalle basierten Chemikalien |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6946118B1 (en) | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
EP1272459B1 (de) * | 2000-03-31 | 2007-06-27 | Trustees Of Tufts College | 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen |
KR20030024683A (ko) * | 2000-06-02 | 2003-03-26 | 유 리우 | 항진균제로서 비-항균성 테트라사이클린 |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US20020128238A1 (en) * | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
HU229577B1 (en) | 2000-07-07 | 2014-02-28 | Tufts College | 9-substituted minocycline derivatives |
US6624168B2 (en) * | 2000-07-07 | 2003-09-23 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
CZ2003343A3 (cs) * | 2000-07-07 | 2003-05-14 | Trustees Of Tufts College | 7-Substituované tetracyklinové sloučeniny |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
WO2002072506A2 (en) | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EA201000388A1 (ru) | 2001-03-13 | 2010-10-29 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта |
EP1241160A1 (de) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
CA2444899C (en) * | 2001-04-24 | 2011-06-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
EP2329828A1 (de) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracycline zur Behandlung von Ischaemie |
AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
JP2005514410A (ja) | 2002-01-08 | 2005-05-19 | パラテック ファーマシューティカルズ インコーポレイテッド | 4−デジメチルアミノテトラサイクリン化合物 |
EA013819B1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
JP2005520846A (ja) | 2002-03-21 | 2005-07-14 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換されたテトラサイクリン化合物。 |
KR20050005466A (ko) * | 2002-05-06 | 2005-01-13 | 콜라제넥스 파마슈티칼스, 인크 | 점막염 및 진균 감염을 동시에 치료하는 방법 |
US20040029843A1 (en) * | 2002-06-20 | 2004-02-12 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
CA2492273C (en) | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
AU2003287218C1 (en) * | 2002-10-24 | 2010-07-15 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
EP2298322A3 (de) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
US7786099B2 (en) * | 2004-01-15 | 2010-08-31 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
US8466132B2 (en) | 2004-10-25 | 2013-06-18 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
EP1805134B1 (de) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracycline und verfahren zu ihrer verwendung |
PA8652001A1 (es) | 2004-11-05 | 2006-10-13 | Wyeth Corp | Metabolitos glucuronidos de tigeciclina y epimeros de los mismos |
US8088755B2 (en) * | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 10−置換テトラサイクリンおよびその使用方法 |
RU2008121238A (ru) * | 2005-12-22 | 2010-01-27 | Вайет (Us) | Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина |
AU2006331688A1 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Oral formulations comprising tigecycline |
AU2007249695A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
WO2007147133A1 (en) * | 2006-06-15 | 2007-12-21 | Serenex, Inc. | Stabilized tetracycline compositions |
US8518912B2 (en) | 2007-11-29 | 2013-08-27 | Actelion Pharmaceuticals Ltd. | Phosphonic acid derivates and their use as P2Y12 receptor antagonists |
SI2323972T1 (sl) | 2008-08-08 | 2013-11-29 | Tetraphase Pharmaceuticals, Inc. | C7-fluoro substituirane tetraciklinske spojine |
EP2424834B1 (de) | 2009-04-30 | 2018-07-11 | President and Fellows of Harvard College | Synthese von tetracyclinen und deren zwischenprodukte |
EP2427425B1 (de) | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetrazyklin verbindungen |
CA2772386C (en) | 2009-08-28 | 2017-09-19 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
EA031523B1 (ru) | 2012-08-31 | 2019-01-31 | Тетрафейз Фармасьютикалс, Инк. | Тетрациклиновые соединения |
MA46567A (fr) | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
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USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
US2482055A (en) * | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
US3007965A (en) * | 1959-02-13 | 1961-11-07 | American Cyanamid Co | New tetracyclines produced by streptomyces aureofaciens |
US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
FR1430859A (de) * | 1960-05-23 | 1966-05-25 | ||
US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
US3829453A (en) * | 1961-08-18 | 1974-08-13 | Pfizer | Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof |
US3360557A (en) * | 1963-05-10 | 1967-12-26 | American Cyanamid Co | 9-hydroxytetracyclines and a process of preparing same |
USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
US4518960A (en) * | 1982-11-23 | 1985-05-21 | Burroughs Corporation | Speed independent selector switch employing M-out-of-N codes |
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
-
1993
- 1993-05-12 SG SG1996002634A patent/SG47520A1/en unknown
- 1993-06-21 DK DK93109850T patent/DK0582810T3/da active
- 1993-06-21 ES ES93109850T patent/ES2173876T3/es not_active Expired - Lifetime
- 1993-06-21 EP EP93109850A patent/EP0582810B1/de not_active Expired - Lifetime
- 1993-06-21 PT PT93109850T patent/PT582810E/pt unknown
- 1993-06-21 DE DE69331774T patent/DE69331774T2/de not_active Expired - Fee Related
- 1993-06-21 AT AT93109850T patent/ATE215530T1/de not_active IP Right Cessation
- 1993-08-04 CZ CZ19931575A patent/CZ289195B6/cs not_active IP Right Cessation
- 1993-08-09 NZ NZ248359A patent/NZ248359A/en unknown
- 1993-08-09 SK SK857-93A patent/SK281871B6/sk unknown
- 1993-08-11 JP JP21792793A patent/JP3639313B2/ja not_active Expired - Fee Related
- 1993-08-11 CA CA002103861A patent/CA2103861C/en not_active Expired - Fee Related
- 1993-08-12 IL IL11975193A patent/IL119751A/en not_active IP Right Cessation
- 1993-08-12 NO NO932872A patent/NO302568B1/no not_active IP Right Cessation
- 1993-08-12 RU RU93048636A patent/RU2127255C1/ru not_active IP Right Cessation
- 1993-08-12 IL IL106677A patent/IL106677A/en not_active IP Right Cessation
- 1993-08-12 FI FI933567A patent/FI933567A/fi unknown
- 1993-08-12 PL PL93300066A patent/PL174022B1/pl not_active IP Right Cessation
- 1993-08-12 PL PL93316768A patent/PL175487B1/pl not_active IP Right Cessation
- 1993-08-12 ZA ZA935892A patent/ZA935892B/xx unknown
- 1993-08-12 KR KR1019930015645A patent/KR100309540B1/ko not_active IP Right Cessation
- 1993-08-12 PL PL93318908A patent/PL174127B1/pl not_active IP Right Cessation
- 1993-08-12 HU HU9302333A patent/HU213269B/hu not_active IP Right Cessation
- 1993-08-12 IL IL11975093A patent/IL119750A/en not_active IP Right Cessation
- 1993-08-12 AU AU44601/93A patent/AU674524B2/en not_active Ceased
- 1993-08-12 PL PL93316767A patent/PL174230B1/pl not_active IP Right Cessation
- 1993-08-12 PH PH46683A patent/PH31210A/en unknown
- 1993-08-13 CN CN93109819A patent/CN1048719C/zh not_active Expired - Fee Related
-
1994
- 1994-03-21 US US08/214,992 patent/US5430162A/en not_active Expired - Lifetime
- 1994-12-08 US US08/352,310 patent/US5886175A/en not_active Expired - Fee Related
- 1994-12-08 US US08/352,407 patent/US5495018A/en not_active Expired - Lifetime
-
1995
- 1995-05-31 US US08/454,966 patent/US5512553A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00672P patent/HU211303A9/hu unknown
-
1996
- 1996-12-03 IL IL11975096A patent/IL119750A0/xx unknown
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