IL119751A - 7-(substituted)-8-(substituted-9-(substituted amino)-6- demethyl-6-deoxytetracycline intermediates - Google Patents

7-(substituted)-8-(substituted-9-(substituted amino)-6- demethyl-6-deoxytetracycline intermediates

Info

Publication number
IL119751A
IL119751A IL11975193A IL11975193A IL119751A IL 119751 A IL119751 A IL 119751A IL 11975193 A IL11975193 A IL 11975193A IL 11975193 A IL11975193 A IL 11975193A IL 119751 A IL119751 A IL 119751A
Authority
IL
Israel
Prior art keywords
group selected
alkyl
group
methyl
ethyl
Prior art date
Application number
IL11975193A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL119751A publication Critical patent/IL119751A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL11975193A 1992-08-13 1993-08-12 7-(substituted)-8-(substituted-9-(substituted amino)-6- demethyl-6-deoxytetracycline intermediates IL119751A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13
IL106677A IL106677A (en) 1992-08-13 1993-08-12 7-(substituted)-8- (substituted-9-( substituted amino)-6- demethyl-6- deoxytetracyclines

Publications (1)

Publication Number Publication Date
IL119751A true IL119751A (en) 1998-09-24

Family

ID=25456505

Family Applications (4)

Application Number Title Priority Date Filing Date
IL11975193A IL119751A (en) 1992-08-13 1993-08-12 7-(substituted)-8-(substituted-9-(substituted amino)-6- demethyl-6-deoxytetracycline intermediates
IL11975093A IL119750A (en) 1992-08-13 1993-08-12 7-(Substituted)-8-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates
IL106677A IL106677A (en) 1992-08-13 1993-08-12 7-(substituted)-8- (substituted-9-( substituted amino)-6- demethyl-6- deoxytetracyclines
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL11975093A IL119750A (en) 1992-08-13 1993-08-12 7-(Substituted)-8-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates
IL106677A IL106677A (en) 1992-08-13 1993-08-12 7-(substituted)-8- (substituted-9-( substituted amino)-6- demethyl-6- deoxytetracyclines
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Country Status (24)

Country Link
US (4) US5430162A (de)
EP (1) EP0582810B1 (de)
JP (1) JP3639313B2 (de)
KR (1) KR100309540B1 (de)
CN (1) CN1048719C (de)
AT (1) ATE215530T1 (de)
AU (1) AU674524B2 (de)
CA (1) CA2103861C (de)
CZ (1) CZ289195B6 (de)
DE (1) DE69331774T2 (de)
DK (1) DK0582810T3 (de)
ES (1) ES2173876T3 (de)
FI (1) FI933567A7 (de)
HU (2) HU213269B (de)
IL (4) IL119751A (de)
NO (1) NO302568B1 (de)
NZ (1) NZ248359A (de)
PH (1) PH31210A (de)
PL (4) PL174127B1 (de)
PT (1) PT582810E (de)
RU (1) RU2127255C1 (de)
SG (1) SG47520A1 (de)
SK (1) SK281871B6 (de)
ZA (1) ZA935892B (de)

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US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
EA016099B1 (ru) * 1999-09-14 2012-02-28 Трастис Оф Тафтс Коллидж Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина
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EP1241160A1 (de) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
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EA201000388A1 (ru) 2001-03-13 2010-10-29 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
EP2186793A1 (de) * 2001-04-24 2010-05-19 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-verbindungen
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
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Also Published As

Publication number Publication date
IL106677A0 (en) 1993-12-08
KR940003925A (ko) 1994-03-14
DE69331774T2 (de) 2002-11-14
AU4460193A (en) 1994-02-17
PT582810E (pt) 2002-08-30
CN1048719C (zh) 2000-01-26
DK0582810T3 (da) 2002-06-03
ZA935892B (en) 1994-03-10
KR100309540B1 (ko) 2002-04-24
RU2127255C1 (ru) 1999-03-10
JPH06228072A (ja) 1994-08-16
HU211303A9 (en) 1995-11-28
CA2103861A1 (en) 1994-02-14
CN1090267A (zh) 1994-08-03
EP0582810B1 (de) 2002-04-03
CZ157593A3 (en) 1994-02-16
EP0582810A1 (de) 1994-02-16
IL106677A (en) 1998-06-15
JP3639313B2 (ja) 2005-04-20
PL174230B1 (pl) 1998-07-31
US5430162A (en) 1995-07-04
SG47520A1 (en) 1998-04-17
NZ248359A (en) 1996-03-26
ES2173876T3 (es) 2002-11-01
PL174127B1 (pl) 1998-06-30
ATE215530T1 (de) 2002-04-15
IL119750A (en) 1998-09-24
US5886175A (en) 1999-03-23
US5495018A (en) 1996-02-27
PL174022B1 (pl) 1998-06-30
IL119750A0 (en) 1997-03-18
HU9302333D0 (en) 1993-10-28
PH31210A (en) 1998-05-05
US5512553A (en) 1996-04-30
CA2103861C (en) 2004-07-27
FI933567A0 (fi) 1993-08-12
FI933567L (fi) 1994-02-14
NO932872D0 (no) 1993-08-12
PL175487B1 (pl) 1999-01-29
PL300066A1 (en) 1994-02-21
HU213269B (en) 1997-04-28
SK281871B6 (sk) 2001-08-06
DE69331774D1 (de) 2002-05-08
NO932872L (no) 1994-02-14
FI933567A7 (fi) 1994-02-14
AU674524B2 (en) 1997-01-02
SK85793A3 (en) 1994-04-06
HUT64945A (en) 1994-03-28
NO302568B1 (no) 1998-03-23
CZ289195B6 (cs) 2001-11-14

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