EP1556007A4 - Substituierte tetracyclin-verbindungen zur behandlung von malaria - Google Patents

Substituierte tetracyclin-verbindungen zur behandlung von malaria

Info

Publication number
EP1556007A4
EP1556007A4 EP03781398A EP03781398A EP1556007A4 EP 1556007 A4 EP1556007 A4 EP 1556007A4 EP 03781398 A EP03781398 A EP 03781398A EP 03781398 A EP03781398 A EP 03781398A EP 1556007 A4 EP1556007 A4 EP 1556007A4
Authority
EP
European Patent Office
Prior art keywords
malaria
treatment
tetracycline compounds
substituted tetracycline
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03781398A
Other languages
English (en)
French (fr)
Other versions
EP1556007A2 (de
Inventor
Michael Draper
Mark L Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Priority to EP10171327A priority Critical patent/EP2277504A1/de
Publication of EP1556007A2 publication Critical patent/EP1556007A2/de
Publication of EP1556007A4 publication Critical patent/EP1556007A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP03781398A 2002-10-24 2003-10-24 Substituierte tetracyclin-verbindungen zur behandlung von malaria Withdrawn EP1556007A4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10171327A EP2277504A1 (de) 2002-10-24 2003-10-24 Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42125902P 2002-10-24 2002-10-24
US421259P 2002-10-24
PCT/US2003/033927 WO2004038001A2 (en) 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria

Publications (2)

Publication Number Publication Date
EP1556007A2 EP1556007A2 (de) 2005-07-27
EP1556007A4 true EP1556007A4 (de) 2008-12-17

Family

ID=32176689

Family Applications (2)

Application Number Title Priority Date Filing Date
EP03781398A Withdrawn EP1556007A4 (de) 2002-10-24 2003-10-24 Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP10171327A Withdrawn EP2277504A1 (de) 2002-10-24 2003-10-24 Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10171327A Withdrawn EP2277504A1 (de) 2002-10-24 2003-10-24 Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria

Country Status (6)

Country Link
EP (2) EP1556007A4 (de)
JP (2) JP2006503898A (de)
AU (3) AU2003287218C1 (de)
CA (1) CA2502464A1 (de)
IL (1) IL209319A0 (de)
WO (1) WO2004038001A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EA200900540A1 (ru) 2002-07-12 2009-12-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
CN101863841A (zh) * 2003-07-09 2010-10-20 帕拉特克药品公司 取代的四环素化合物
WO2005009944A1 (en) * 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN103224474B (zh) * 2004-05-21 2016-08-03 哈佛大学校长及研究员协会 四环素及其类似物的合成
EP1807387A2 (de) * 2004-10-25 2007-07-18 Paratek Pharmaceuticals, Inc. Substituierte tetracyclin-verbindungen
FR2891744B1 (fr) * 2005-10-06 2009-10-09 France Etat Armement Application a la chimioprophylaxie du paludisme d'une association de chloroquine et de doxycycline
JP5335664B2 (ja) 2006-04-07 2013-11-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ テトラサイクリンおよびその類似体の合成
EP3056487B1 (de) 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthese eines enon-zwischenprodukts
CA3051994A1 (en) * 2006-12-21 2008-07-03 Paul Abato Substituted tetracycline compounds
EP2144870A2 (de) * 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Verfahren zur synthese und reinigung von aminoalkyl-tetracyclin-verbindungen
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
PT2682387E (pt) 2008-08-08 2016-02-03 Tetraphase Pharmaceuticals Inc Compostos de tetraciclina substituídos com c7-flúor
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
WO2010129057A2 (en) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
PL2470500T3 (pl) 2009-08-28 2018-03-30 Tetraphase Pharmaceuticals, Inc. Związki tetracyklinowe
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物
NO2738156T3 (de) * 2011-07-26 2018-06-02
PL2890673T3 (pl) 2012-08-31 2019-06-28 Tetraphase Pharmaceuticals, Inc. Związki tetracyklinowe
MX2015011760A (es) 2013-03-15 2016-06-10 Melinta Therapeutics Inc Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos.
JP7492335B2 (ja) 2016-10-19 2024-05-29 テトラフェース ファーマシューティカルズ,インコーポレイテッド エラバサイクリンの結晶形
JP7418345B2 (ja) * 2018-04-06 2024-01-19 パラテック ファーマシューティカルズ,インコーポレイテッド サレサイクリン塩酸塩を製造する方法
CN117486749A (zh) * 2023-11-23 2024-02-02 传健生物医药(厦门)有限公司 一种奥马环素杂质的制备方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (en) * 1997-12-19 1999-06-24 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
WO2000064479A1 (en) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders
WO2002000208A2 (de) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Kombinationspräparate von 3-n-formylhydroxylaminopropylphosphonsäurederivaten oder 3-n-acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen
WO2002004406A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 9-substituted minocycline compounds
WO2002004407A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 7-substituted tetracycline compounds
WO2002072022A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2002085303A2 (en) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2003005971A2 (en) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds

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US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (de) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
YU40295B (en) 1977-04-07 1985-12-31 Pliva Pharm & Chem Works Process for preparing n2-tert.butyl-11a-halo-6-demethyl-6-deoxy-6-methylene tetracycline
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
YU41093B (en) 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
EP0599397B1 (de) 1992-11-17 1996-08-28 The Research Foundation Of State University Of New York Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5834450A (en) 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5919395A (en) 1997-10-30 1999-07-06 Shell Oil Company Polyol combination
IL137445A0 (en) * 1998-01-23 2001-07-24 Tufts College Pharmaceutically active compounds and methods of use thereof
CA2351703C (en) * 1998-11-18 2008-12-30 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethylaminotetracycline derivatives
US6326023B1 (en) * 2000-03-28 2001-12-04 Council Of Scientific & Industrial Research Synergistic anti-malarial formulation
US7045507B2 (en) * 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
EA201000491A1 (ru) * 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
CN101863841A (zh) * 2003-07-09 2010-10-20 帕拉特克药品公司 取代的四环素化合物
JP5706185B2 (ja) 2011-02-22 2015-04-22 富士レビオ株式会社 測定装置及び測定方法
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (en) * 1997-12-19 1999-06-24 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
WO2000064479A1 (en) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders
WO2002000208A2 (de) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Kombinationspräparate von 3-n-formylhydroxylaminopropylphosphonsäurederivaten oder 3-n-acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen
WO2002004406A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 9-substituted minocycline compounds
WO2002004407A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 7-substituted tetracycline compounds
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2002072022A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002085303A2 (en) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2003005971A2 (en) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds

Non-Patent Citations (3)

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Title
BUNNANG D ET AL: "QUININE-TETRACYCLINE FOR MULTIDRUG RESISTANT FALCIPARUM MALARIA", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, PROJECT OD SEAMEO, BANGKOK, vol. 27, no. 1, 1 March 1996 (1996-03-01), pages 15 - 18, XP009060760, ISSN: 0125-1562 *
DRAPER M P ET AL: "NOVEL TETRACYCLINE DERIVATIVES AS ANTIMALARIAL DRUGS", PROGRAM AND ABSTRACTS OF THE INTERSCIENCE CONFERENCE ONANTIMICROBIAL AGENTS AND CHEMOTHERAPY, PY, WASHINGTON, DC, vol. 41, 17 December 2001 (2001-12-17), pages 496, XP001208128, ISSN: 0733-6373 *
TOAMA M A: "IN VITRO SYNERGISM BETWEEN TETRACYCLINES AND ANTIMALARIALS", CHEMOTHERAPY, S. KARGER, BASEL, CH, vol. 26, no. 3, 1 January 1980 (1980-01-01), pages 191 - 195, XP009060770, ISSN: 0009-3157 *

Also Published As

Publication number Publication date
IL209319A0 (en) 2011-01-31
EP1556007A2 (de) 2005-07-27
JP2006503898A (ja) 2006-02-02
AU2003287218C1 (en) 2010-07-15
AU2010200971A1 (en) 2010-04-01
CA2502464A1 (en) 2004-05-06
WO2004038001A2 (en) 2004-05-06
EP2277504A1 (de) 2011-01-26
AU2010200973A1 (en) 2010-04-01
WO2004038001A3 (en) 2004-11-11
AU2003287218B2 (en) 2009-12-17
JP2011037890A (ja) 2011-02-24
AU2003287218A1 (en) 2004-05-13

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