EP1556007A4 - Substituierte tetracyclin-verbindungen zur behandlung von malaria - Google Patents
Substituierte tetracyclin-verbindungen zur behandlung von malariaInfo
- Publication number
- EP1556007A4 EP1556007A4 EP03781398A EP03781398A EP1556007A4 EP 1556007 A4 EP1556007 A4 EP 1556007A4 EP 03781398 A EP03781398 A EP 03781398A EP 03781398 A EP03781398 A EP 03781398A EP 1556007 A4 EP1556007 A4 EP 1556007A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- malaria
- treatment
- tetracycline compounds
- substituted tetracycline
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004098 Tetracycline Substances 0.000 title 1
- 201000004792 malaria Diseases 0.000 title 1
- 229960002180 tetracycline Drugs 0.000 title 1
- 229930101283 tetracycline Natural products 0.000 title 1
- 235000019364 tetracycline Nutrition 0.000 title 1
- -1 tetracycline compounds Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10171327A EP2277504A1 (de) | 2002-10-24 | 2003-10-24 | Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42125902P | 2002-10-24 | 2002-10-24 | |
US421259P | 2002-10-24 | ||
PCT/US2003/033927 WO2004038001A2 (en) | 2002-10-24 | 2003-10-24 | Substituted tetracycline compounds for the treatment of malaria |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1556007A2 EP1556007A2 (de) | 2005-07-27 |
EP1556007A4 true EP1556007A4 (de) | 2008-12-17 |
Family
ID=32176689
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03781398A Withdrawn EP1556007A4 (de) | 2002-10-24 | 2003-10-24 | Substituierte tetracyclin-verbindungen zur behandlung von malaria |
EP10171327A Withdrawn EP2277504A1 (de) | 2002-10-24 | 2003-10-24 | Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10171327A Withdrawn EP2277504A1 (de) | 2002-10-24 | 2003-10-24 | Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria |
Country Status (6)
Country | Link |
---|---|
EP (2) | EP1556007A4 (de) |
JP (2) | JP2006503898A (de) |
AU (3) | AU2003287218C1 (de) |
CA (1) | CA2502464A1 (de) |
IL (1) | IL209319A0 (de) |
WO (1) | WO2004038001A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EA200900540A1 (ru) | 2002-07-12 | 2009-12-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
CN101863841A (zh) * | 2003-07-09 | 2010-10-20 | 帕拉特克药品公司 | 取代的四环素化合物 |
WO2005009944A1 (en) * | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
CN103224474B (zh) * | 2004-05-21 | 2016-08-03 | 哈佛大学校长及研究员协会 | 四环素及其类似物的合成 |
EP1807387A2 (de) * | 2004-10-25 | 2007-07-18 | Paratek Pharmaceuticals, Inc. | Substituierte tetracyclin-verbindungen |
FR2891744B1 (fr) * | 2005-10-06 | 2009-10-09 | France Etat Armement | Application a la chimioprophylaxie du paludisme d'une association de chloroquine et de doxycycline |
JP5335664B2 (ja) | 2006-04-07 | 2013-11-06 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | テトラサイクリンおよびその類似体の合成 |
EP3056487B1 (de) | 2006-10-11 | 2018-02-21 | President and Fellows of Harvard College | Synthese eines enon-zwischenprodukts |
CA3051994A1 (en) * | 2006-12-21 | 2008-07-03 | Paul Abato | Substituted tetracycline compounds |
EP2144870A2 (de) * | 2007-04-27 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Verfahren zur synthese und reinigung von aminoalkyl-tetracyclin-verbindungen |
PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
PT2682387E (pt) | 2008-08-08 | 2016-02-03 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
PL2470500T3 (pl) | 2009-08-28 | 2018-03-30 | Tetraphase Pharmaceuticals, Inc. | Związki tetracyklinowe |
CN101967108B (zh) * | 2010-09-13 | 2013-06-19 | 苏春华 | 一种美他环素的衍生物 |
NO2738156T3 (de) * | 2011-07-26 | 2018-06-02 | ||
PL2890673T3 (pl) | 2012-08-31 | 2019-06-28 | Tetraphase Pharmaceuticals, Inc. | Związki tetracyklinowe |
MX2015011760A (es) | 2013-03-15 | 2016-06-10 | Melinta Therapeutics Inc | Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos. |
JP7492335B2 (ja) | 2016-10-19 | 2024-05-29 | テトラフェース ファーマシューティカルズ,インコーポレイテッド | エラバサイクリンの結晶形 |
JP7418345B2 (ja) * | 2018-04-06 | 2024-01-19 | パラテック ファーマシューティカルズ,インコーポレイテッド | サレサイクリン塩酸塩を製造する方法 |
CN117486749A (zh) * | 2023-11-23 | 2024-02-02 | 传健生物医药(厦门)有限公司 | 一种奥马环素杂质的制备方法 |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
WO1999030720A1 (en) * | 1997-12-19 | 1999-06-24 | New York University | Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha |
WO2000064479A1 (en) * | 1999-04-27 | 2000-11-02 | Antibody Systems, Inc. | Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders |
WO2002000208A2 (de) * | 2000-06-29 | 2002-01-03 | Jomaa Pharmaka Gmbh | Kombinationspräparate von 3-n-formylhydroxylaminopropylphosphonsäurederivaten oder 3-n-acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen |
WO2002004406A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 9-substituted minocycline compounds |
WO2002004407A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 7-substituted tetracycline compounds |
WO2002072022A2 (en) * | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
WO2002072532A1 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7, 9-substituted tetracycline compounds |
WO2002085303A2 (en) * | 2001-04-24 | 2002-10-31 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
WO2003005971A2 (en) * | 2001-07-13 | 2003-01-23 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
WO2003079984A2 (en) * | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
NL6607516A (de) | 1966-05-31 | 1967-12-01 | ||
DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
YU40295B (en) | 1977-04-07 | 1985-12-31 | Pliva Pharm & Chem Works | Process for preparing n2-tert.butyl-11a-halo-6-demethyl-6-deoxy-6-methylene tetracycline |
US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
YU41093B (en) | 1978-04-12 | 1986-12-31 | Pliva Pharm & Chem Works | Process for preparing 6-deoxy-5hydroxy-tetracycline |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
EP0599397B1 (de) | 1992-11-17 | 1996-08-28 | The Research Foundation Of State University Of New York | Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes |
US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5371076A (en) | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
US5834450A (en) | 1994-02-17 | 1998-11-10 | Pfizer Inc. | 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
US5919395A (en) | 1997-10-30 | 1999-07-06 | Shell Oil Company | Polyol combination |
IL137445A0 (en) * | 1998-01-23 | 2001-07-24 | Tufts College | Pharmaceutically active compounds and methods of use thereof |
CA2351703C (en) * | 1998-11-18 | 2008-12-30 | Collagenex Pharmaceuticals, Inc. | Novel 4-dedimethylaminotetracycline derivatives |
US6326023B1 (en) * | 2000-03-28 | 2001-12-04 | Council Of Scientific & Industrial Research | Synergistic anti-malarial formulation |
US7045507B2 (en) * | 2001-03-14 | 2006-05-16 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
CN101863841A (zh) * | 2003-07-09 | 2010-10-20 | 帕拉特克药品公司 | 取代的四环素化合物 |
JP5706185B2 (ja) | 2011-02-22 | 2015-04-22 | 富士レビオ株式会社 | 測定装置及び測定方法 |
US9713502B2 (en) | 2014-03-09 | 2017-07-25 | Gyrus Acmi, Inc. | Narrow band imaging with surgical loupes |
-
2003
- 2003-10-24 CA CA002502464A patent/CA2502464A1/en not_active Abandoned
- 2003-10-24 AU AU2003287218A patent/AU2003287218C1/en not_active Ceased
- 2003-10-24 WO PCT/US2003/033927 patent/WO2004038001A2/en active Application Filing
- 2003-10-24 EP EP03781398A patent/EP1556007A4/de not_active Withdrawn
- 2003-10-24 EP EP10171327A patent/EP2277504A1/de not_active Withdrawn
- 2003-10-24 JP JP2004547165A patent/JP2006503898A/ja active Pending
-
2010
- 2010-03-16 AU AU2010200971A patent/AU2010200971A1/en not_active Abandoned
- 2010-03-16 AU AU2010200973A patent/AU2010200973A1/en not_active Abandoned
- 2010-10-15 JP JP2010232352A patent/JP2011037890A/ja active Pending
- 2010-11-15 IL IL209319A patent/IL209319A0/en unknown
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
WO1999030720A1 (en) * | 1997-12-19 | 1999-06-24 | New York University | Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha |
WO2000064479A1 (en) * | 1999-04-27 | 2000-11-02 | Antibody Systems, Inc. | Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders |
WO2002000208A2 (de) * | 2000-06-29 | 2002-01-03 | Jomaa Pharmaka Gmbh | Kombinationspräparate von 3-n-formylhydroxylaminopropylphosphonsäurederivaten oder 3-n-acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen |
WO2002004406A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 9-substituted minocycline compounds |
WO2002004407A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 7-substituted tetracycline compounds |
WO2002072532A1 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7, 9-substituted tetracycline compounds |
WO2002072022A2 (en) * | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
WO2002085303A2 (en) * | 2001-04-24 | 2002-10-31 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
WO2003005971A2 (en) * | 2001-07-13 | 2003-01-23 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
WO2003079984A2 (en) * | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
Non-Patent Citations (3)
Title |
---|
BUNNANG D ET AL: "QUININE-TETRACYCLINE FOR MULTIDRUG RESISTANT FALCIPARUM MALARIA", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, PROJECT OD SEAMEO, BANGKOK, vol. 27, no. 1, 1 March 1996 (1996-03-01), pages 15 - 18, XP009060760, ISSN: 0125-1562 * |
DRAPER M P ET AL: "NOVEL TETRACYCLINE DERIVATIVES AS ANTIMALARIAL DRUGS", PROGRAM AND ABSTRACTS OF THE INTERSCIENCE CONFERENCE ONANTIMICROBIAL AGENTS AND CHEMOTHERAPY, PY, WASHINGTON, DC, vol. 41, 17 December 2001 (2001-12-17), pages 496, XP001208128, ISSN: 0733-6373 * |
TOAMA M A: "IN VITRO SYNERGISM BETWEEN TETRACYCLINES AND ANTIMALARIALS", CHEMOTHERAPY, S. KARGER, BASEL, CH, vol. 26, no. 3, 1 January 1980 (1980-01-01), pages 191 - 195, XP009060770, ISSN: 0009-3157 * |
Also Published As
Publication number | Publication date |
---|---|
IL209319A0 (en) | 2011-01-31 |
EP1556007A2 (de) | 2005-07-27 |
JP2006503898A (ja) | 2006-02-02 |
AU2003287218C1 (en) | 2010-07-15 |
AU2010200971A1 (en) | 2010-04-01 |
CA2502464A1 (en) | 2004-05-06 |
WO2004038001A2 (en) | 2004-05-06 |
EP2277504A1 (de) | 2011-01-26 |
AU2010200973A1 (en) | 2010-04-01 |
WO2004038001A3 (en) | 2004-11-11 |
AU2003287218B2 (en) | 2009-12-17 |
JP2011037890A (ja) | 2011-02-24 |
AU2003287218A1 (en) | 2004-05-13 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20050523 |
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AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
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AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: NELSON, MARK, L. Inventor name: DRAPER, MICHAEL |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20081119 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 33/06 20060101ALI20081113BHEP Ipc: A61K 31/65 20060101ALI20081113BHEP Ipc: A61K 9/48 20060101ALI20081113BHEP Ipc: A61K 9/02 20060101AFI20050429BHEP |
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17Q | First examination report despatched |
Effective date: 20090226 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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18W | Application withdrawn |
Effective date: 20101026 |