EP1556007A4 - Composes tetracycline substituee servant au traitement du paludisme - Google Patents

Composes tetracycline substituee servant au traitement du paludisme

Info

Publication number
EP1556007A4
EP1556007A4 EP03781398A EP03781398A EP1556007A4 EP 1556007 A4 EP1556007 A4 EP 1556007A4 EP 03781398 A EP03781398 A EP 03781398A EP 03781398 A EP03781398 A EP 03781398A EP 1556007 A4 EP1556007 A4 EP 1556007A4
Authority
EP
European Patent Office
Prior art keywords
malaria
treatment
tetracycline compounds
substituted tetracycline
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03781398A
Other languages
German (de)
English (en)
Other versions
EP1556007A2 (fr
Inventor
Michael Draper
Mark L Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Priority to EP10171327A priority Critical patent/EP2277504A1/fr
Publication of EP1556007A2 publication Critical patent/EP1556007A2/fr
Publication of EP1556007A4 publication Critical patent/EP1556007A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP03781398A 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme Withdrawn EP1556007A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10171327A EP2277504A1 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42125902P 2002-10-24 2002-10-24
US421259P 2002-10-24
PCT/US2003/033927 WO2004038001A2 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Publications (2)

Publication Number Publication Date
EP1556007A2 EP1556007A2 (fr) 2005-07-27
EP1556007A4 true EP1556007A4 (fr) 2008-12-17

Family

ID=32176689

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10171327A Withdrawn EP2277504A1 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme
EP03781398A Withdrawn EP1556007A4 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10171327A Withdrawn EP2277504A1 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Country Status (6)

Country Link
EP (2) EP2277504A1 (fr)
JP (2) JP2006503898A (fr)
AU (3) AU2003287218C1 (fr)
CA (1) CA2502464A1 (fr)
IL (1) IL209319A0 (fr)
WO (1) WO2004038001A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
CA2492273C (fr) 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee en 3, 10, et 12a
EA201001081A1 (ru) 2003-07-09 2011-02-28 Пэрэтек Фамэсьютикэлс, Инк. Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
EP2292590A3 (fr) * 2003-07-09 2012-05-02 Paratek Pharmaceuticals, Inc. Promédicaments de composés de tétracycline 9-aminométhylé
AU2005244988C1 (en) 2004-05-21 2012-06-28 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2284156A3 (fr) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
FR2891744B1 (fr) * 2005-10-06 2009-10-09 France Etat Armement Application a la chimioprophylaxie du paludisme d'une association de chloroquine et de doxycycline
US8486921B2 (en) 2006-04-07 2013-07-16 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP3056487B1 (fr) 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthèse d'un intermédiaire de l'énone
EP2452935A3 (fr) * 2006-12-21 2012-08-29 Paratek Pharmaceuticals, Inc. Dérivés de tétracycline pour le traitement d'infections bactériennes, virales et parasites
AU2008246119A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
JP5496202B2 (ja) 2008-08-08 2014-05-21 テトラフェース ファーマシューティカルズ，インコーポレイテッド Ｃ７−フルオロ置換テトラサイクリン化合物
WO2010126607A2 (fr) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
PL2427425T3 (pl) 2009-05-08 2017-08-31 Tetraphase Pharmaceuticals, Inc. Związki tetracyklinowe
ES2654987T3 (es) 2009-08-28 2018-02-15 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物
WO2013013505A1 (fr) 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 Composé tétracycline substitué par 9-aminométhyle
DK2890673T3 (en) 2012-08-31 2019-03-18 Tetraphase Pharmaceuticals Inc tetracycline
TWI641372B (zh) 2013-03-15 2018-11-21 美商梅琳塔有限責任公司 使用抗生素治療超重和肥胖患者感染的方法
KR102660864B1 (ko) 2016-10-19 2024-04-25 테트라페이즈 파마슈티컬스, 인코포레이티드 에라바사이클린의 결정질 형태
CN115380022A (zh) * 2018-04-06 2022-11-22 帕拉特克药品公司 萨瑞环素盐酸盐的制造方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (fr) * 1997-12-19 1999-06-24 New York University Inhibition de la cyclooxygenase-2 et du facteur de necrose des tumeurs alpha
WO2000064479A1 (fr) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions contenant des tetracyclines et servant a traiter des infections et d'autres maladies virales hemorragiques
WO2002000208A2 (fr) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Preparations de derives d'acide 3-n-formylhydroxylaminopropylphosphonique ou de derives d'acide 3-n-acetylhydroxylaminopropylphosphonique combines avec des principes actifs pharmaceutiques speciaux
WO2002004406A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de monocycline 9-substitues
WO2002004407A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de tetracycline substitues en 7
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002072532A1 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
WO2002085303A2 (fr) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
WO2003005971A2 (fr) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Composes de tetracycline a activites therapeutiques cibles
WO2003079984A2 (fr) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (fr) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
YU40295B (en) 1977-04-07 1985-12-31 Pliva Pharm & Chem Works Process for preparing n2-tert.butyl-11a-halo-6-demethyl-6-deoxy-6-methylene tetracycline
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
YU41093B (en) 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
EP0599397B1 (fr) 1992-11-17 1996-08-28 The Research Foundation Of State University Of New York Tétracyclines comprenant les tétracyclines modifiées chimiquement afin d'être non-antimicrobiennes inhibent la réticulation excessive du collagène lors du diabète
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5834450A (en) 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5919395A (en) 1997-10-30 1999-07-06 Shell Oil Company Polyol combination
JP2002501026A (ja) * 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
WO2000028983A1 (fr) * 1998-11-18 2000-05-25 Collagenex Pharmaceuticals, Inc. Nouveaux derives de 4-dedimethy laminotetra cycline
US6326023B1 (en) * 2000-03-28 2001-12-04 Council Of Scientific & Industrial Research Synergistic anti-malarial formulation
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
EP2311451A1 (fr) * 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Composés de tétracycline à substitution amino-méthyle
EA201001081A1 (ru) * 2003-07-09 2011-02-28 Пэрэтек Фамэсьютикэлс, Инк. Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
JP5706185B2 (ja) 2011-02-22 2015-04-22 富士レビオ株式会社 測定装置及び測定方法
US9713502B2 (en) 2014-03-09 2017-07-25 Gyrus Acmi, Inc. Narrow band imaging with surgical loupes

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (fr) * 1997-12-19 1999-06-24 New York University Inhibition de la cyclooxygenase-2 et du facteur de necrose des tumeurs alpha
WO2000064479A1 (fr) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions contenant des tetracyclines et servant a traiter des infections et d'autres maladies virales hemorragiques
WO2002000208A2 (fr) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Preparations de derives d'acide 3-n-formylhydroxylaminopropylphosphonique ou de derives d'acide 3-n-acetylhydroxylaminopropylphosphonique combines avec des principes actifs pharmaceutiques speciaux
WO2002004406A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de monocycline 9-substitues
WO2002004407A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de tetracycline substitues en 7
WO2002072532A1 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002085303A2 (fr) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
WO2003005971A2 (fr) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Composes de tetracycline a activites therapeutiques cibles
WO2003079984A2 (fr) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUNNANG D ET AL: "QUININE-TETRACYCLINE FOR MULTIDRUG RESISTANT FALCIPARUM MALARIA", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, PROJECT OD SEAMEO, BANGKOK, vol. 27, no. 1, 1 March 1996 (1996-03-01), pages 15 - 18, XP009060760, ISSN: 0125-1562 *
DRAPER M P ET AL: "NOVEL TETRACYCLINE DERIVATIVES AS ANTIMALARIAL DRUGS", PROGRAM AND ABSTRACTS OF THE INTERSCIENCE CONFERENCE ONANTIMICROBIAL AGENTS AND CHEMOTHERAPY, PY, WASHINGTON, DC, vol. 41, 17 December 2001 (2001-12-17), pages 496, XP001208128, ISSN: 0733-6373 *
TOAMA M A: "IN VITRO SYNERGISM BETWEEN TETRACYCLINES AND ANTIMALARIALS", CHEMOTHERAPY, S. KARGER, BASEL, CH, vol. 26, no. 3, 1 January 1980 (1980-01-01), pages 191 - 195, XP009060770, ISSN: 0009-3157 *

Also Published As

Publication number Publication date
EP1556007A2 (fr) 2005-07-27
WO2004038001A3 (fr) 2004-11-11
AU2003287218A1 (en) 2004-05-13
EP2277504A1 (fr) 2011-01-26
IL209319A0 (en) 2011-01-31
AU2003287218B2 (en) 2009-12-17
CA2502464A1 (fr) 2004-05-06
AU2003287218C1 (en) 2010-07-15
WO2004038001A2 (fr) 2004-05-06
AU2010200971A1 (en) 2010-04-01
JP2006503898A (ja) 2006-02-02
AU2010200973A1 (en) 2010-04-01
JP2011037890A (ja) 2011-02-24

Similar Documents

Publication Publication Date Title
IL209319A0 (en) Substituted tetracycline compounds for the treatment of malaria
IL214625A0 (en) Substituted tetracycline compounds
AU2003235759A8 (en) 4-dedimethylamino tetracycline compounds
IL213220A0 (en) Amino-methyl substituted tetracycline compounds
IL206939A0 (en) Substituted tetracycline compounds
PL375532A1 (en) Benzimidazol-1-yl-thiophene compounds for the treatment of cancer
IL209842A0 (en) Compounds for the treatment of metabolic disorders
AU2003249244A1 (en) Methods for the treatment of neoplasms
GB0205256D0 (en) Novel compounds
AU2003286728A8 (en) Compounds for the treatment of metabolic disorders
AU2003258145A8 (en) Substituted phenylindoles for the treatment of hiv
HK1075936A1 (en) Vaccine for the prevention of malaria
AU2003215150A8 (en) Therapeutic compounds
GB0207246D0 (en) Novel compounds
AU2003282510A8 (en) Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
AU2003240174A8 (en) Compositions for the treatment of edematous-firbrosclerotic panniculopathy
AU2002304733A1 (en) Amino-aza-cyclohexanes for the treatment of malaria
SG122745A1 (en) Compositions for the treatment of malaria
GB0229370D0 (en) Uses of calphostin c
AU2003274753A1 (en) Amide compounds for the treatment of hyperlipidemia
SI1485352T1 (en) Azaspiro compounds for the treatment of pain
GB0200136D0 (en) Therapeutic compounds
GB0201509D0 (en) Therapeutic Compounds
GB0200135D0 (en) Therapeutic Compounds
GB0200134D0 (en) Therapeutic compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050523

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

RIN1 Information on inventor provided before grant (corrected)

Inventor name: NELSON, MARK, L.

Inventor name: DRAPER, MICHAEL

A4 Supplementary search report drawn up and despatched

Effective date: 20081119

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 33/06 20060101ALI20081113BHEP

Ipc: A61K 31/65 20060101ALI20081113BHEP

Ipc: A61K 9/48 20060101ALI20081113BHEP

Ipc: A61K 9/02 20060101AFI20050429BHEP

17Q First examination report despatched

Effective date: 20090226

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20101026