EP1556007A4 - Substituted tetracycline compounds for the treatment of malaria - Google Patents

Substituted tetracycline compounds for the treatment of malaria

Info

Publication number
EP1556007A4
EP1556007A4 EP03781398A EP03781398A EP1556007A4 EP 1556007 A4 EP1556007 A4 EP 1556007A4 EP 03781398 A EP03781398 A EP 03781398A EP 03781398 A EP03781398 A EP 03781398A EP 1556007 A4 EP1556007 A4 EP 1556007A4
Authority
EP
European Patent Office
Prior art keywords
malaria
treatment
tetracycline compounds
substituted tetracycline
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03781398A
Other languages
German (de)
French (fr)
Other versions
EP1556007A2 (en
Inventor
Michael Draper
Mark L Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Priority to EP10171327A priority Critical patent/EP2277504A1/en
Publication of EP1556007A2 publication Critical patent/EP1556007A2/en
Publication of EP1556007A4 publication Critical patent/EP1556007A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP03781398A 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria Withdrawn EP1556007A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10171327A EP2277504A1 (en) 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42125902P 2002-10-24 2002-10-24
US421259P 2002-10-24
PCT/US2003/033927 WO2004038001A2 (en) 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria

Publications (2)

Publication Number Publication Date
EP1556007A2 EP1556007A2 (en) 2005-07-27
EP1556007A4 true EP1556007A4 (en) 2008-12-17

Family

ID=32176689

Family Applications (2)

Application Number Title Priority Date Filing Date
EP03781398A Withdrawn EP1556007A4 (en) 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria
EP10171327A Withdrawn EP2277504A1 (en) 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10171327A Withdrawn EP2277504A1 (en) 2002-10-24 2003-10-24 Substituted tetracycline compounds for the treatment of malaria

Country Status (6)

Country Link
EP (2) EP1556007A4 (en)
JP (2) JP2006503898A (en)
AU (3) AU2003287218C1 (en)
CA (1) CA2502464A1 (en)
IL (1) IL209319A0 (en)
WO (1) WO2004038001A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1534300A4 (en) 2002-07-12 2008-04-23 Paratek Pharm Innc 3, 10, and 12a substituted tetracycline compounds
JP4738333B2 (en) * 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド Prodrugs of 9-aminomethyltetracycline compounds
EP2298323A3 (en) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2005244988C1 (en) * 2004-05-21 2012-06-28 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2284150A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
FR2891744B1 (en) * 2005-10-06 2009-10-09 France Etat Armement APPLICATION TO THE CHIMIOPROPHYLAXIS OF MALARIA OF A CHLOROQUINE AND DOXYCYCLINE ASSOCIATION
JP5335664B2 (en) 2006-04-07 2013-11-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ Synthesis of tetracycline and its analogs.
US7763735B2 (en) 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
KR101538175B1 (en) * 2006-12-21 2015-07-20 파라테크 파마슈티컬스, 인크. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
EP2144870A2 (en) * 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
PT2271348T (en) * 2008-03-28 2018-04-16 Paratek Pharm Innc Oral tablet formulation of tetracycline compound
NZ603568A (en) 2008-08-08 2014-05-30 Tetraphase Pharmaceuticals Inc C7-fluoro substituted tetracycline compounds
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof
DK2427425T3 (en) 2009-05-08 2017-06-12 Tetraphase Pharmaceuticals Inc tetracycline
CN102596898B (en) 2009-08-28 2016-01-27 四相制药公司 tetracycline compound
CN101967108B (en) * 2010-09-13 2013-06-19 苏春华 Methacycline derivative
PT2738156T (en) * 2011-07-26 2018-03-28 Kbp Biosciences Usa Inc 9-aminomethyl substituted tetracycline compounds
NZ705849A (en) 2012-08-31 2018-06-29 Tetraphase Pharmaceuticals Inc Tetracycline compounds
EP2969004A4 (en) 2013-03-15 2016-09-21 Melinta Therapeutics Inc Methods of treating infections in overweight and obese patients using antibiotics
DK3529236T3 (en) 2016-10-19 2024-05-13 Tetraphase Pharmaceuticals Inc CRYSTAL FORMS OF ERAVACYCLINE
CN115380022A (en) * 2018-04-06 2022-11-22 帕拉特克药品公司 Preparation method of sarracycline hydrochloride

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (en) * 1997-12-19 1999-06-24 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
WO2000064479A1 (en) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders
WO2002000208A2 (en) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Combination preparations of 3-n-formylhydroxylaminopropyl phosphonic acid derivatives or 3-n-acetylhydroxylaminopropyl phosphonic acid derivatives combined with specific pharmaceutical active agents
WO2002004407A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 7-substituted tetracycline compounds
WO2002004406A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 9-substituted minocycline compounds
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2002072022A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002085303A2 (en) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2003005971A2 (en) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds

Family Cites Families (27)

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US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (en) 1966-05-31 1967-12-01
DE1767891C3 (en) 1968-06-28 1980-10-30 Pfizer Process for the preparation of aqueous medicinal solutions for parenteral, peroral and local use containing a tetracycline derivative
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (en) 1974-09-06 1976-03-18 Merck Patent Gmbh TETRACYCLIC COMPOUNDS AND PROCEDURES FOR THEIR PRODUCTION
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
YU40295B (en) 1977-04-07 1985-12-31 Pliva Pharm & Chem Works Process for preparing n2-tert.butyl-11a-halo-6-demethyl-6-deoxy-6-methylene tetracycline
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
YU41093B (en) 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
DE69304292T2 (en) 1992-11-17 1997-01-02 Univ New York Tetracyclines including non-antimicrobial, chemically modified tetracyclines inhibiting excessive collagen cross-linking in diabetes
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5834450A (en) 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5919395A (en) 1997-10-30 1999-07-06 Shell Oil Company Polyol combination
AU2466099A (en) * 1998-01-23 1999-08-09 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
JP5060685B2 (en) * 1998-11-18 2012-10-31 ガルデマ ラボラトリーズ インコーポレイテッド Novel 4-dedimethylaminotetracycline derivative
US6326023B1 (en) * 2000-03-28 2001-12-04 Council Of Scientific & Industrial Research Synergistic anti-malarial formulation
JP2005504722A (en) * 2001-03-14 2005-02-17 パラテック ファーマシューティカルズ インコーポレイテッド Substituted tetracycline compounds as synergistic antifungal agents
CN102531948A (en) * 2002-03-08 2012-07-04 帕拉特克药品公司 Amino-methyl substituted tetracycline compounds
EP2298323A3 (en) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP5706185B2 (en) 2011-02-22 2015-04-22 富士レビオ株式会社 Measuring apparatus and measuring method
US9713502B2 (en) 2014-03-09 2017-07-25 Gyrus Acmi, Inc. Narrow band imaging with surgical loupes

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (en) * 1997-12-19 1999-06-24 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
WO2000064479A1 (en) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders
WO2002000208A2 (en) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Combination preparations of 3-n-formylhydroxylaminopropyl phosphonic acid derivatives or 3-n-acetylhydroxylaminopropyl phosphonic acid derivatives combined with specific pharmaceutical active agents
WO2002004407A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 7-substituted tetracycline compounds
WO2002004406A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 9-substituted minocycline compounds
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2002072022A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002085303A2 (en) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2003005971A2 (en) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUNNANG D ET AL: "QUININE-TETRACYCLINE FOR MULTIDRUG RESISTANT FALCIPARUM MALARIA", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, PROJECT OD SEAMEO, BANGKOK, vol. 27, no. 1, 1 March 1996 (1996-03-01), pages 15 - 18, XP009060760, ISSN: 0125-1562 *
DRAPER M P ET AL: "NOVEL TETRACYCLINE DERIVATIVES AS ANTIMALARIAL DRUGS", PROGRAM AND ABSTRACTS OF THE INTERSCIENCE CONFERENCE ONANTIMICROBIAL AGENTS AND CHEMOTHERAPY, PY, WASHINGTON, DC, vol. 41, 17 December 2001 (2001-12-17), pages 496, XP001208128, ISSN: 0733-6373 *
TOAMA M A: "IN VITRO SYNERGISM BETWEEN TETRACYCLINES AND ANTIMALARIALS", CHEMOTHERAPY, S. KARGER, BASEL, CH, vol. 26, no. 3, 1 January 1980 (1980-01-01), pages 191 - 195, XP009060770, ISSN: 0009-3157 *

Also Published As

Publication number Publication date
AU2010200973A1 (en) 2010-04-01
AU2010200971A1 (en) 2010-04-01
AU2003287218B2 (en) 2009-12-17
EP1556007A2 (en) 2005-07-27
JP2006503898A (en) 2006-02-02
AU2003287218A1 (en) 2004-05-13
WO2004038001A3 (en) 2004-11-11
JP2011037890A (en) 2011-02-24
WO2004038001A2 (en) 2004-05-06
EP2277504A1 (en) 2011-01-26
AU2003287218C1 (en) 2010-07-15
IL209319A0 (en) 2011-01-31
CA2502464A1 (en) 2004-05-06

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Inventor name: NELSON, MARK, L.

Inventor name: DRAPER, MICHAEL

A4 Supplementary search report drawn up and despatched

Effective date: 20081119

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 33/06 20060101ALI20081113BHEP

Ipc: A61K 31/65 20060101ALI20081113BHEP

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