SG47520A1 - New method for the production of 9-amino-6-demethyl-6-deoxytetracycline - Google Patents
New method for the production of 9-amino-6-demethyl-6-deoxytetracyclineInfo
- Publication number
- SG47520A1 SG47520A1 SG1996002634A SG1996002634A SG47520A1 SG 47520 A1 SG47520 A1 SG 47520A1 SG 1996002634 A SG1996002634 A SG 1996002634A SG 1996002634 A SG1996002634 A SG 1996002634A SG 47520 A1 SG47520 A1 SG 47520A1
- Authority
- SG
- Singapore
- Prior art keywords
- deoxytetracycline
- demethyl
- amino
- production
- new method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/20—Diazonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Seasonings (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92859892A | 1992-08-13 | 1992-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG47520A1 true SG47520A1 (en) | 1998-04-17 |
Family
ID=25456505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996002634A SG47520A1 (en) | 1992-08-13 | 1993-05-12 | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US5430162A (da) |
| EP (1) | EP0582810B1 (da) |
| JP (1) | JP3639313B2 (da) |
| KR (1) | KR100309540B1 (da) |
| CN (1) | CN1048719C (da) |
| AT (1) | ATE215530T1 (da) |
| AU (1) | AU674524B2 (da) |
| CA (1) | CA2103861C (da) |
| CZ (1) | CZ289195B6 (da) |
| DE (1) | DE69331774T2 (da) |
| DK (1) | DK0582810T3 (da) |
| ES (1) | ES2173876T3 (da) |
| FI (1) | FI933567A (da) |
| HU (2) | HU213269B (da) |
| IL (4) | IL106677A (da) |
| NO (1) | NO302568B1 (da) |
| NZ (1) | NZ248359A (da) |
| PH (1) | PH31210A (da) |
| PL (4) | PL175487B1 (da) |
| PT (1) | PT582810E (da) |
| RU (1) | RU2127255C1 (da) |
| SG (1) | SG47520A1 (da) |
| SK (1) | SK281871B6 (da) |
| ZA (1) | ZA935892B (da) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| CN102336680A (zh) * | 1999-09-14 | 2012-02-01 | 塔夫茨大学信托人 | 用基于过渡金属的化学制备取代四环素的方法 |
| US6946118B1 (en) | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| WO2001074761A1 (en) * | 2000-03-31 | 2001-10-11 | Trustees Of Tufts College | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
| AU2001268135A1 (en) * | 2000-06-02 | 2001-12-17 | Golub, Lorne, M | Non-antibacterial tetracycline as anti-fungal agents |
| WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| AU2001271556A1 (en) * | 2000-07-07 | 2002-01-21 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
| KR100699390B1 (ko) | 2000-07-07 | 2007-03-28 | 트러스티즈 오브 터프츠 칼리지 | 9-치환된 미노사이클린 화합물 |
| CN102336679A (zh) * | 2000-07-07 | 2012-02-01 | 塔夫茨大学信托人 | 7-取代的四环素化合物 |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| WO2002072506A2 (en) | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| MXPA03008165A (es) | 2001-03-13 | 2003-12-12 | Paratek Pharm Innc | Compuestos tetraciclina sustituidos en la posicion 7,9. |
| EP1399414B1 (en) * | 2001-04-24 | 2010-01-13 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| WO2003005971A2 (en) | 2001-07-13 | 2003-01-23 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
| WO2003055441A2 (en) | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
| EP1474380A4 (en) | 2002-01-08 | 2007-04-18 | Paratek Pharm Innc | 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS |
| EA200802365A1 (ru) * | 2002-03-08 | 2009-08-28 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| EP1503981A4 (en) * | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
| WO2003092629A2 (en) * | 2002-05-06 | 2003-11-13 | Collagenex Pharmaceuticals, Inc. | Methods of simultaneously treating mucositis and fungal infection |
| WO2004000223A2 (en) * | 2002-06-20 | 2003-12-31 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
| EP1534300A4 (en) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
| EP2277504A1 (en) * | 2002-10-24 | 2011-01-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| JP4733028B2 (ja) | 2003-07-09 | 2011-07-27 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP1716101A1 (en) * | 2004-01-15 | 2006-11-02 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
| EP1805134B1 (en) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2949644A3 (en) | 2004-10-25 | 2016-04-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US7534766B2 (en) | 2004-11-05 | 2009-05-19 | Wyeth | Glucuronide metabolites and epimers thereof of tigecycline |
| US8088755B2 (en) * | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| EP1910273A2 (en) * | 2005-07-21 | 2008-04-16 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| WO2007075792A1 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Methods of treating gastrointestinal tract infections with tigecycline |
| BRPI0620646A2 (pt) * | 2005-12-22 | 2011-11-22 | Wyeth Corp | composição farmacêutica compreendendo tigeciclina e seu uso |
| JP2009537139A (ja) | 2006-05-15 | 2009-10-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法 |
| AR061485A1 (es) * | 2006-06-15 | 2008-08-27 | Serenex Inc | Composiciones estabilizadas de tetraciclina |
| CA2706475C (en) | 2007-11-29 | 2016-05-03 | Actelion Pharmaceuticals Ltd | Phosphonic acid derivates and their use as p2y12 receptor antagonists |
| KR101856178B1 (ko) | 2008-08-08 | 2018-05-10 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Ｃ７-플루오로 치환된 테트라시클린 화합물 |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| WO2010129057A2 (en) * | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| NO2470500T3 (da) | 2009-08-28 | 2018-03-03 | ||
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| SG11201903327PA (en) | 2016-10-19 | 2019-05-30 | Tetraphase Pharmaceuticals Inc | Crystalline forms of eravacycline |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
| US2482055A (en) * | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
| US3007965A (en) * | 1959-02-13 | 1961-11-07 | American Cyanamid Co | New tetracyclines produced by streptomyces aureofaciens |
| US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
| FR1430859A (da) * | 1960-05-23 | 1966-05-25 | ||
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3829453A (en) * | 1961-08-18 | 1974-08-13 | Pfizer | Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof |
| US3360557A (en) * | 1963-05-10 | 1967-12-26 | American Cyanamid Co | 9-hydroxytetracyclines and a process of preparing same |
| USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
| US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
| US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
| US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US4518960A (en) * | 1982-11-23 | 1985-05-21 | Burroughs Corporation | Speed independent selector switch employing M-out-of-N codes |
| SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
| US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
-
1993
- 1993-05-12 SG SG1996002634A patent/SG47520A1/en unknown
- 1993-06-21 AT AT93109850T patent/ATE215530T1/de not_active IP Right Cessation
- 1993-06-21 ES ES93109850T patent/ES2173876T3/es not_active Expired - Lifetime
- 1993-06-21 DE DE69331774T patent/DE69331774T2/de not_active Expired - Fee Related
- 1993-06-21 PT PT93109850T patent/PT582810E/pt unknown
- 1993-06-21 DK DK93109850T patent/DK0582810T3/da active
- 1993-06-21 EP EP93109850A patent/EP0582810B1/en not_active Expired - Lifetime
- 1993-08-04 CZ CZ19931575A patent/CZ289195B6/cs not_active IP Right Cessation
- 1993-08-09 SK SK857-93A patent/SK281871B6/sk unknown
- 1993-08-09 NZ NZ248359A patent/NZ248359A/en unknown
- 1993-08-11 JP JP21792793A patent/JP3639313B2/ja not_active Expired - Fee Related
- 1993-08-11 CA CA002103861A patent/CA2103861C/en not_active Expired - Fee Related
- 1993-08-12 PL PL93316768A patent/PL175487B1/pl not_active IP Right Cessation
- 1993-08-12 PH PH46683A patent/PH31210A/en unknown
- 1993-08-12 PL PL93316767A patent/PL174230B1/pl not_active IP Right Cessation
- 1993-08-12 FI FI933567A patent/FI933567A/fi unknown
- 1993-08-12 KR KR1019930015645A patent/KR100309540B1/ko not_active IP Right Cessation
- 1993-08-12 IL IL106677A patent/IL106677A/en not_active IP Right Cessation
- 1993-08-12 IL IL11975093A patent/IL119750A/en not_active IP Right Cessation
- 1993-08-12 AU AU44601/93A patent/AU674524B2/en not_active Ceased
- 1993-08-12 HU HU9302333A patent/HU213269B/hu not_active IP Right Cessation
- 1993-08-12 PL PL93318908A patent/PL174127B1/pl not_active IP Right Cessation
- 1993-08-12 NO NO932872A patent/NO302568B1/no not_active IP Right Cessation
- 1993-08-12 RU RU93048636A patent/RU2127255C1/ru not_active IP Right Cessation
- 1993-08-12 IL IL11975193A patent/IL119751A/en not_active IP Right Cessation
- 1993-08-12 ZA ZA935892A patent/ZA935892B/xx unknown
- 1993-08-12 PL PL93300066A patent/PL174022B1/pl not_active IP Right Cessation
- 1993-08-13 CN CN93109819A patent/CN1048719C/zh not_active Expired - Fee Related
-
1994
- 1994-03-21 US US08/214,992 patent/US5430162A/en not_active Expired - Lifetime
- 1994-12-08 US US08/352,310 patent/US5886175A/en not_active Expired - Fee Related
- 1994-12-08 US US08/352,407 patent/US5495018A/en not_active Expired - Lifetime
-
1995
- 1995-05-31 US US08/454,966 patent/US5512553A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00672P patent/HU211303A9/hu unknown
-
1996
- 1996-12-03 IL IL11975096A patent/IL119750A0/xx unknown
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