IL106677A - N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines - Google Patents

N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines

Info

Publication number
IL106677A
IL106677A IL106677A IL10667793A IL106677A IL 106677 A IL106677 A IL 106677A IL 106677 A IL106677 A IL 106677A IL 10667793 A IL10667793 A IL 10667793A IL 106677 A IL106677 A IL 106677A
Authority
IL
Israel
Prior art keywords
group selected
alkyl
methyl
group
ethyl
Prior art date
Application number
IL106677A
Other languages
English (en)
Hebrew (he)
Other versions
IL106677A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to IL11975193A priority Critical patent/IL119751A/en
Priority to IL11975093A priority patent/IL119750A/en
Publication of IL106677A0 publication Critical patent/IL106677A0/xx
Priority to IL11975096A priority patent/IL119750A0/xx
Priority to IL11975196A priority patent/IL119751A0/xx
Publication of IL106677A publication Critical patent/IL106677A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
IL106677A 1992-08-13 1993-08-12 N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines IL106677A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL11975193A IL119751A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL11975093A IL119750A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates
IL11975196A IL119751A0 (en) 1993-08-12 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (2)

Publication Number Publication Date
IL106677A0 IL106677A0 (en) 1993-12-08
IL106677A true IL106677A (en) 1998-06-15

Family

ID=25456505

Family Applications (4)

Application Number Title Priority Date Filing Date
IL11975093A IL119750A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL11975193A IL119751A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL106677A IL106677A (en) 1992-08-13 1993-08-12 N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL11975093A IL119750A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL11975193A IL119751A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Country Status (24)

Country Link
US (4) US5430162A (da)
EP (1) EP0582810B1 (da)
JP (1) JP3639313B2 (da)
KR (1) KR100309540B1 (da)
CN (1) CN1048719C (da)
AT (1) ATE215530T1 (da)
AU (1) AU674524B2 (da)
CA (1) CA2103861C (da)
CZ (1) CZ289195B6 (da)
DE (1) DE69331774T2 (da)
DK (1) DK0582810T3 (da)
ES (1) ES2173876T3 (da)
FI (1) FI933567A (da)
HU (2) HU213269B (da)
IL (4) IL119750A (da)
NO (1) NO302568B1 (da)
NZ (1) NZ248359A (da)
PH (1) PH31210A (da)
PL (4) PL174230B1 (da)
PT (1) PT582810E (da)
RU (1) RU2127255C1 (da)
SG (1) SG47520A1 (da)
SK (1) SK281871B6 (da)
ZA (1) ZA935892B (da)

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US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
EP1666453A1 (en) * 1999-09-14 2006-06-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
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US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
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EP1303479B1 (en) * 2000-07-07 2011-04-06 Trustees Of Tufts College 7-, 8- and 9-substituted tetracycline compounds
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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CN102336679A (zh) * 2000-07-07 2012-02-01 塔夫茨大学信托人 7-取代的四环素化合物
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
JP2005506291A (ja) 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ， インク． ７，９−置換テトラサイクリン化合物
CA2444899C (en) * 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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EP2277504A1 (en) * 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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Also Published As

Publication number Publication date
FI933567A (fi) 1994-02-14
PL175487B1 (pl) 1999-01-29
US5512553A (en) 1996-04-30
CZ157593A3 (en) 1994-02-16
ES2173876T3 (es) 2002-11-01
PH31210A (en) 1998-05-05
ZA935892B (en) 1994-03-10
AU4460193A (en) 1994-02-17
PL300066A1 (en) 1994-02-21
IL119750A0 (en) 1997-03-18
EP0582810A1 (en) 1994-02-16
IL119750A (en) 1998-09-24
US5430162A (en) 1995-07-04
KR100309540B1 (ko) 2002-04-24
DE69331774D1 (de) 2002-05-08
US5886175A (en) 1999-03-23
CN1090267A (zh) 1994-08-03
NO302568B1 (no) 1998-03-23
NO932872L (no) 1994-02-14
NO932872D0 (no) 1993-08-12
PL174230B1 (pl) 1998-07-31
CN1048719C (zh) 2000-01-26
JP3639313B2 (ja) 2005-04-20
DE69331774T2 (de) 2002-11-14
SG47520A1 (en) 1998-04-17
JPH06228072A (ja) 1994-08-16
CZ289195B6 (cs) 2001-11-14
ATE215530T1 (de) 2002-04-15
SK85793A3 (en) 1994-04-06
RU2127255C1 (ru) 1999-03-10
IL119751A (en) 1998-09-24
SK281871B6 (sk) 2001-08-06
US5495018A (en) 1996-02-27
CA2103861C (en) 2004-07-27
KR940003925A (ko) 1994-03-14
IL106677A0 (en) 1993-12-08
DK0582810T3 (da) 2002-06-03
HUT64945A (en) 1994-03-28
NZ248359A (en) 1996-03-26
PL174127B1 (pl) 1998-06-30
HU211303A9 (en) 1995-11-28
CA2103861A1 (en) 1994-02-14
PT582810E (pt) 2002-08-30
AU674524B2 (en) 1997-01-02
PL174022B1 (pl) 1998-06-30
HU213269B (en) 1997-04-28
HU9302333D0 (en) 1993-10-28
EP0582810B1 (en) 2002-04-03
FI933567A0 (fi) 1993-08-12

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