IL106677A - N)-7ותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקלינים - Google Patents
N)-7ותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםInfo
- Publication number
- IL106677A IL106677A IL106677A IL10667793A IL106677A IL 106677 A IL106677 A IL 106677A IL 106677 A IL106677 A IL 106677A IL 10667793 A IL10667793 A IL 10667793A IL 106677 A IL106677 A IL 106677A
- Authority
- IL
- Israel
- Prior art keywords
- group selected
- alkyl
- methyl
- group
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/20—Diazonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11975093A IL119750A (he) | 1992-08-13 | 1993-08-12 | 7-)מותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםתוצרי ביניים חדשים |
IL11975193A IL119751A (he) | 1992-08-13 | 1993-08-12 | 7-)מותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםתוצרי ביניים חדשים |
IL11975196A IL119751A0 (en) | 1993-08-12 | 1996-12-03 | Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates |
IL11975096A IL119750A0 (en) | 1992-08-13 | 1996-12-03 | Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92859892A | 1992-08-13 | 1992-08-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL106677A0 IL106677A0 (en) | 1993-12-08 |
IL106677A true IL106677A (he) | 1998-06-15 |
Family
ID=25456505
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11975093A IL119750A (he) | 1992-08-13 | 1993-08-12 | 7-)מותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםתוצרי ביניים חדשים |
IL106677A IL106677A (he) | 1992-08-13 | 1993-08-12 | N)-7ותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקלינים |
IL11975193A IL119751A (he) | 1992-08-13 | 1993-08-12 | 7-)מותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםתוצרי ביניים חדשים |
IL11975096A IL119750A0 (en) | 1992-08-13 | 1996-12-03 | Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11975093A IL119750A (he) | 1992-08-13 | 1993-08-12 | 7-)מותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםתוצרי ביניים חדשים |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11975193A IL119751A (he) | 1992-08-13 | 1993-08-12 | 7-)מותמר(-8-)מותמר-9-)אמינו מותמר(-6-דמתיל-6-דאוקסיטטראציקליניםתוצרי ביניים חדשים |
IL11975096A IL119750A0 (en) | 1992-08-13 | 1996-12-03 | Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates |
Country Status (24)
Country | Link |
---|---|
US (4) | US5430162A (he) |
EP (1) | EP0582810B1 (he) |
JP (1) | JP3639313B2 (he) |
KR (1) | KR100309540B1 (he) |
CN (1) | CN1048719C (he) |
AT (1) | ATE215530T1 (he) |
AU (1) | AU674524B2 (he) |
CA (1) | CA2103861C (he) |
CZ (1) | CZ289195B6 (he) |
DE (1) | DE69331774T2 (he) |
DK (1) | DK0582810T3 (he) |
ES (1) | ES2173876T3 (he) |
FI (1) | FI933567A (he) |
HU (2) | HU213269B (he) |
IL (4) | IL119750A (he) |
NO (1) | NO302568B1 (he) |
NZ (1) | NZ248359A (he) |
PH (1) | PH31210A (he) |
PL (4) | PL175487B1 (he) |
PT (1) | PT582810E (he) |
RU (1) | RU2127255C1 (he) |
SG (1) | SG47520A1 (he) |
SK (1) | SK281871B6 (he) |
ZA (1) | ZA935892B (he) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
EP2327686A3 (en) * | 1999-09-14 | 2012-08-22 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6946118B1 (en) | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
JP2004505012A (ja) * | 2000-03-31 | 2004-02-19 | トラスティーズ・オブ・タフツ・カレッジ | 7−および9−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物 |
KR20030024683A (ko) * | 2000-06-02 | 2003-03-26 | 유 리우 | 항진균제로서 비-항균성 테트라사이클린 |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
AU2001271556A1 (en) * | 2000-07-07 | 2002-01-21 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
MXPA03000055A (es) * | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
AU2001271642B2 (en) * | 2000-07-07 | 2006-01-05 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
WO2002072506A2 (en) | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
JP2005506291A (ja) | 2001-03-13 | 2005-03-03 | パラテック ファーマシューティカルズ, インク. | 7,9−置換テトラサイクリン化合物 |
US20040092490A1 (en) * | 2001-04-24 | 2004-05-13 | Michael Draper | Substituted tetracycline compounds for the treatment of malaria |
EP2332550A1 (en) * | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of neurodegenerative diseases |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
WO2003055441A2 (en) * | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
EP2311799A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
IL163931A0 (en) * | 2002-03-08 | 2005-12-18 | Paratek Pharm Innc | Amino-methyl substituted tetracyline compounds |
CN1653037A (zh) | 2002-03-21 | 2005-08-10 | 帕拉特克药品公司 | 取代的四环素化合物 |
CA2500134A1 (en) * | 2002-05-06 | 2003-11-13 | Collagenex Pharmaceuticals, Inc. | Methods of simultaneously treating mucositis and fungal infection |
US20040029843A1 (en) * | 2002-06-20 | 2004-02-12 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
EA012136B1 (ru) | 2002-07-12 | 2009-08-28 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
AU2003287218C1 (en) * | 2002-10-24 | 2010-07-15 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
AU2004259659B2 (en) | 2003-07-09 | 2011-11-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EP2332904A3 (en) * | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derivatives of tetracycline compounds |
KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
EP2295419A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
EP2301916A3 (en) | 2004-10-25 | 2011-09-28 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
PA8652001A1 (es) | 2004-11-05 | 2006-10-13 | Wyeth Corp | Metabolitos glucuronidos de tigeciclina y epimeros de los mismos |
AU2006210406C1 (en) * | 2005-02-04 | 2013-03-07 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 10−置換テトラサイクリンおよびその使用方法 |
CA2631632A1 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Methods of treating gastrointestinal tract infections with tigecycline |
CA2632213A1 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Oral formulations comprising tigecycline |
EP2537934A3 (en) | 2006-05-15 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
WO2007147133A1 (en) * | 2006-06-15 | 2007-12-21 | Serenex, Inc. | Stabilized tetracycline compositions |
RU2483072C2 (ru) | 2007-11-29 | 2013-05-27 | Актелион Фармасьютиклз Лтд | Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12 |
MX2011001367A (es) | 2008-08-08 | 2011-06-28 | Tetraphase Pharmaceuticals Inc | Compuestos de tetraciclina sustituidos con fluor en c7. |
US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
ES2627772T3 (es) | 2009-05-08 | 2017-07-31 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
DK2470500T3 (en) | 2009-08-28 | 2018-01-08 | Tetraphase Pharmaceuticals Inc | tetracycline |
EP3461809A1 (en) | 2012-08-31 | 2019-04-03 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
CN117903083A (zh) | 2016-10-19 | 2024-04-19 | 四相制药公司 | 艾若威四环素的结晶形式 |
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USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
US2482055A (en) * | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
US3007965A (en) * | 1959-02-13 | 1961-11-07 | American Cyanamid Co | New tetracyclines produced by streptomyces aureofaciens |
US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
FR1430859A (he) * | 1960-05-23 | 1966-05-25 | ||
US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
US3829453A (en) * | 1961-08-18 | 1974-08-13 | Pfizer | Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof |
US3360557A (en) * | 1963-05-10 | 1967-12-26 | American Cyanamid Co | 9-hydroxytetracyclines and a process of preparing same |
USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
US4518960A (en) * | 1982-11-23 | 1985-05-21 | Burroughs Corporation | Speed independent selector switch employing M-out-of-N codes |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
-
1993
- 1993-05-12 SG SG1996002634A patent/SG47520A1/en unknown
- 1993-06-21 DE DE69331774T patent/DE69331774T2/de not_active Expired - Fee Related
- 1993-06-21 EP EP93109850A patent/EP0582810B1/en not_active Expired - Lifetime
- 1993-06-21 DK DK93109850T patent/DK0582810T3/da active
- 1993-06-21 PT PT93109850T patent/PT582810E/pt unknown
- 1993-06-21 AT AT93109850T patent/ATE215530T1/de not_active IP Right Cessation
- 1993-06-21 ES ES93109850T patent/ES2173876T3/es not_active Expired - Lifetime
- 1993-08-04 CZ CZ19931575A patent/CZ289195B6/cs not_active IP Right Cessation
- 1993-08-09 NZ NZ248359A patent/NZ248359A/en unknown
- 1993-08-09 SK SK857-93A patent/SK281871B6/sk unknown
- 1993-08-11 CA CA002103861A patent/CA2103861C/en not_active Expired - Fee Related
- 1993-08-11 JP JP21792793A patent/JP3639313B2/ja not_active Expired - Fee Related
- 1993-08-12 AU AU44601/93A patent/AU674524B2/en not_active Ceased
- 1993-08-12 KR KR1019930015645A patent/KR100309540B1/ko not_active IP Right Cessation
- 1993-08-12 ZA ZA935892A patent/ZA935892B/xx unknown
- 1993-08-12 PL PL93316768A patent/PL175487B1/pl not_active IP Right Cessation
- 1993-08-12 PH PH46683A patent/PH31210A/en unknown
- 1993-08-12 FI FI933567A patent/FI933567A/fi unknown
- 1993-08-12 PL PL93316767A patent/PL174230B1/pl not_active IP Right Cessation
- 1993-08-12 RU RU93048636A patent/RU2127255C1/ru not_active IP Right Cessation
- 1993-08-12 NO NO932872A patent/NO302568B1/no not_active IP Right Cessation
- 1993-08-12 IL IL11975093A patent/IL119750A/he not_active IP Right Cessation
- 1993-08-12 IL IL106677A patent/IL106677A/he not_active IP Right Cessation
- 1993-08-12 PL PL93300066A patent/PL174022B1/pl not_active IP Right Cessation
- 1993-08-12 HU HU9302333A patent/HU213269B/hu not_active IP Right Cessation
- 1993-08-12 PL PL93318908A patent/PL174127B1/pl not_active IP Right Cessation
- 1993-08-12 IL IL11975193A patent/IL119751A/he not_active IP Right Cessation
- 1993-08-13 CN CN93109819A patent/CN1048719C/zh not_active Expired - Fee Related
-
1994
- 1994-03-21 US US08/214,992 patent/US5430162A/en not_active Expired - Lifetime
- 1994-12-08 US US08/352,407 patent/US5495018A/en not_active Expired - Lifetime
- 1994-12-08 US US08/352,310 patent/US5886175A/en not_active Expired - Fee Related
-
1995
- 1995-05-31 US US08/454,966 patent/US5512553A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00672P patent/HU211303A9/hu unknown
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1996
- 1996-12-03 IL IL11975096A patent/IL119750A0/xx unknown
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