BR9915333A - Derivados de 3,4-dihidroquinolina fluorada como inibidores de nos - Google Patents
Derivados de 3,4-dihidroquinolina fluorada como inibidores de nosInfo
- Publication number
- BR9915333A BR9915333A BR9915333-5A BR9915333A BR9915333A BR 9915333 A BR9915333 A BR 9915333A BR 9915333 A BR9915333 A BR 9915333A BR 9915333 A BR9915333 A BR 9915333A
- Authority
- BR
- Brazil
- Prior art keywords
- fluorinated
- nos inhibitors
- dihydroquinoline derivatives
- derivatives
- dihydroquinoline
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- DNNVRTZJRKIUFK-UHFFFAOYSA-N 3,4-dihydroquinoline Chemical class C1=CC=C2N=CCCC2=C1 DNNVRTZJRKIUFK-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE 3,4-DIHIDROQUINOLINA FLUORADA COMO INIBIDORES DE NOS"<D>. São descritos compostos da fórmula (I), assim como o processo para sua preparação e seu emprego em medicamentos como inibidores de NOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19854042 | 1998-11-13 | ||
PCT/EP1999/008519 WO2000029381A1 (de) | 1998-11-13 | 1999-11-10 | Fluorierte 3,4-dihydrochinolin-derivate als nos-inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915333A true BR9915333A (pt) | 2001-10-09 |
Family
ID=7888748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915333-5A BR9915333A (pt) | 1998-11-13 | 1999-11-10 | Derivados de 3,4-dihidroquinolina fluorada como inibidores de nos |
Country Status (17)
Country | Link |
---|---|
US (1) | US6579883B1 (pt) |
EP (1) | EP1129077B9 (pt) |
JP (1) | JP2002529535A (pt) |
KR (1) | KR20010080438A (pt) |
CN (1) | CN1161338C (pt) |
AT (1) | ATE293605T1 (pt) |
AU (1) | AU764074B2 (pt) |
BR (1) | BR9915333A (pt) |
CA (1) | CA2350443A1 (pt) |
CZ (1) | CZ20011679A3 (pt) |
DE (1) | DE59911958D1 (pt) |
HU (1) | HUP0104180A3 (pt) |
NO (1) | NO320393B1 (pt) |
NZ (1) | NZ510875A (pt) |
PL (1) | PL347584A1 (pt) |
SK (1) | SK6512001A3 (pt) |
WO (1) | WO2000029381A1 (pt) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
AU4515696A (en) | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
AU6945096A (en) | 1995-09-14 | 1997-04-01 | Nippon Kayaku Kabushiki Kaisha | Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient |
ATE261942T1 (de) | 1996-03-29 | 2004-04-15 | Pfizer | 6-phenylpyridinderivate |
DE19845830A1 (de) | 1998-09-24 | 2000-03-30 | Schering Ag | Aminoalkyl-3,4-dihydrochinolin-Derivate und ihre Verwendung in Arzneimitteln |
-
1999
- 1999-11-10 BR BR9915333-5A patent/BR9915333A/pt not_active IP Right Cessation
- 1999-11-10 WO PCT/EP1999/008519 patent/WO2000029381A1/de not_active Application Discontinuation
- 1999-11-10 EP EP99963289A patent/EP1129077B9/de not_active Expired - Lifetime
- 1999-11-10 AU AU19656/00A patent/AU764074B2/en not_active Ceased
- 1999-11-10 KR KR1020017006026A patent/KR20010080438A/ko not_active Application Discontinuation
- 1999-11-10 NZ NZ510875A patent/NZ510875A/en unknown
- 1999-11-10 DE DE59911958T patent/DE59911958D1/de not_active Expired - Fee Related
- 1999-11-10 HU HU0104180A patent/HUP0104180A3/hu unknown
- 1999-11-10 US US09/831,514 patent/US6579883B1/en not_active Expired - Fee Related
- 1999-11-10 CZ CZ20011679A patent/CZ20011679A3/cs unknown
- 1999-11-10 JP JP2000582368A patent/JP2002529535A/ja active Pending
- 1999-11-10 CA CA002350443A patent/CA2350443A1/en not_active Abandoned
- 1999-11-10 AT AT99963289T patent/ATE293605T1/de not_active IP Right Cessation
- 1999-11-10 CN CNB998132292A patent/CN1161338C/zh not_active Expired - Fee Related
- 1999-11-10 PL PL99347584A patent/PL347584A1/xx not_active Application Discontinuation
- 1999-11-10 SK SK651-2001A patent/SK6512001A3/sk unknown
-
2001
- 2001-05-11 NO NO20012328A patent/NO320393B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU1965600A (en) | 2000-06-05 |
HUP0104180A3 (en) | 2002-12-28 |
HUP0104180A2 (hu) | 2002-02-28 |
JP2002529535A (ja) | 2002-09-10 |
EP1129077B9 (de) | 2005-07-20 |
NO320393B1 (no) | 2005-11-28 |
NO20012328L (no) | 2001-05-11 |
NZ510875A (en) | 2003-10-31 |
CA2350443A1 (en) | 2000-05-25 |
KR20010080438A (ko) | 2001-08-22 |
US6579883B1 (en) | 2003-06-17 |
ATE293605T1 (de) | 2005-05-15 |
CZ20011679A3 (cs) | 2001-08-15 |
EP1129077A1 (de) | 2001-09-05 |
EP1129077B1 (de) | 2005-04-20 |
AU764074B2 (en) | 2003-08-07 |
SK6512001A3 (en) | 2001-12-03 |
PL347584A1 (en) | 2002-04-08 |
WO2000029381A1 (de) | 2000-05-25 |
DE59911958D1 (de) | 2005-05-25 |
CN1326443A (zh) | 2001-12-12 |
NO20012328D0 (no) | 2001-05-11 |
CN1161338C (zh) | 2004-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADONA RPI 1954 DE 17/06/2008. |