HRP20050059B8 - Novi inhibitori kinaza - Google Patents

Novi inhibitori kinaza

Info

Publication number
HRP20050059B8
HRP20050059B8 HRP20050059A HRP20050059A HRP20050059B8 HR P20050059 B8 HRP20050059 B8 HR P20050059B8 HR P20050059 A HRP20050059 A HR P20050059A HR P20050059 A HRP20050059 A HR P20050059A HR P20050059 B8 HRP20050059 B8 HR P20050059B8
Authority
HR
Croatia
Prior art keywords
compounds
formula
kinases
novel inhibitors
useful
Prior art date
Application number
HRP20050059A
Other languages
English (en)
Inventor
Rajeev Bhide
Louis J Lombardo
Stephanie Barbosa
Zhen-Wei Chai
Ligang Qian
Jeffrey Robl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HRP20050059A2 publication Critical patent/HRP20050059A2/hr
Publication of HRP20050059B1 publication Critical patent/HRP20050059B1/hr
Publication of HRP20050059B8 publication Critical patent/HRP20050059B8/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)

Abstract

Predmetni izum se odnosi na spojeve formule (I) i njihove farmaceutski prihvatljive soli. Spojevi formule (I) inhibiraju aktivnost tirozin kinaze receptora faktora rasta kao što su VEGFR-2 i FGFR-1, što ih čini korisnim u liječenju karcinoma. Spojevi formule (I) su također korisni za liječenje drugih oboljenja povezanih sa putevima prijenosa signala koji djeluju preko receptora faktora rasta.
HRP20050059A 2002-07-19 2005-01-19 Novi inhibitori kinaza HRP20050059B8 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39725602P 2002-07-19 2002-07-19
US44721303P 2003-02-13 2003-02-13
PCT/US2003/022826 WO2004009784A2 (en) 2002-07-19 2003-07-18 Novel inhibitors of kinases

Publications (3)

Publication Number Publication Date
HRP20050059A2 HRP20050059A2 (en) 2005-04-30
HRP20050059B1 HRP20050059B1 (hr) 2015-02-27
HRP20050059B8 true HRP20050059B8 (hr) 2016-03-25

Family

ID=30773005

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20050059A HRP20050059B8 (hr) 2002-07-19 2005-01-19 Novi inhibitori kinaza
HR20050058A HRP20050058A2 (en) 2002-07-19 2005-01-19 Azaindole kinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
HR20050058A HRP20050058A2 (en) 2002-07-19 2005-01-19 Azaindole kinase inhibitors

Country Status (33)

Country Link
US (6) US6869952B2 (hr)
EP (3) EP2280012A3 (hr)
JP (2) JP4361485B2 (hr)
KR (1) KR100901939B1 (hr)
CN (3) CN101880283B (hr)
AR (1) AR040500A1 (hr)
AT (2) ATE505471T1 (hr)
AU (2) AU2003254017A1 (hr)
BR (2) BR0312801A (hr)
CA (2) CA2492665A1 (hr)
CO (1) CO5680407A2 (hr)
CY (1) CY1112628T1 (hr)
DE (1) DE60336732D1 (hr)
DK (1) DK1534290T3 (hr)
ES (1) ES2377963T3 (hr)
GE (2) GEP20074213B (hr)
HK (1) HK1072545A1 (hr)
HR (2) HRP20050059B8 (hr)
IL (3) IL166129A0 (hr)
IS (2) IS7646A (hr)
MX (2) MXPA05000716A (hr)
MY (1) MY134848A (hr)
NO (2) NO330132B1 (hr)
NZ (1) NZ537523A (hr)
PE (1) PE20040680A1 (hr)
PL (2) PL216663B1 (hr)
PT (1) PT1534290E (hr)
RS (2) RS52325B (hr)
RU (2) RU2005104818A (hr)
SI (1) SI1534290T1 (hr)
TW (1) TWI329112B (hr)
UA (1) UA82846C2 (hr)
WO (2) WO2004009601A1 (hr)

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EP0881669B1 (en) * 1997-05-30 2005-12-14 STMicroelectronics S.r.l. Manufacturing process of a germanium implanted heterojunction bipolar transistor
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
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JP2005529890A (ja) 2002-04-23 2005-10-06 ブリストル−マイヤーズ　スクイブ　カンパニー キナーゼ阻害剤として有用なアリールケトンピロロトリアジン化合物
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TW200420565A (en) 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
EP1590335A4 (en) 2003-02-05 2006-03-08 Bristol Myers Squibb Co PROCESS FOR THE PRODUCTION OF PYRROLOTRIAZINKINASE INHIBITORS
NZ544797A (en) 2003-07-18 2011-04-29 Amgen Fremont Inc Specific antibodies that bind HGF and neutralise binding of HGF to met
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
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US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
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