KR100901939B1 - 신규한 키나제 억제제 - Google Patents
신규한 키나제 억제제 Download PDFInfo
- Publication number
- KR100901939B1 KR100901939B1 KR1020087022726A KR20087022726A KR100901939B1 KR 100901939 B1 KR100901939 B1 KR 100901939B1 KR 1020087022726 A KR1020087022726 A KR 1020087022726A KR 20087022726 A KR20087022726 A KR 20087022726A KR 100901939 B1 KR100901939 B1 KR 100901939B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- mmol
- yloxy
- fluoro
- compound
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
Abstract
Description
Claims (1)
- (2S)-1-[4-(4-플루오로-2-메틸-1H-인돌-5-일옥시)-5-메틸피롤로[2,1-f][1,2,4]트리아진-6-일옥시]-프로판-2-올 화합물 또는 이의 제약상 허용되는 염.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39725602P | 2002-07-19 | 2002-07-19 | |
US60/397,256 | 2002-07-19 | ||
US44721303P | 2003-02-13 | 2003-02-13 | |
US60/447,213 | 2003-02-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020057000977A Division KR100869417B1 (ko) | 2002-07-19 | 2003-07-18 | 신규한 키나제 억제제 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20080095906A KR20080095906A (ko) | 2008-10-29 |
KR100901939B1 true KR100901939B1 (ko) | 2009-06-10 |
Family
ID=30773005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020087022726A KR100901939B1 (ko) | 2002-07-19 | 2003-07-18 | 신규한 키나제 억제제 |
Country Status (33)
Country | Link |
---|---|
US (6) | US6869952B2 (ko) |
EP (3) | EP1539763B1 (ko) |
JP (2) | JP4381978B2 (ko) |
KR (1) | KR100901939B1 (ko) |
CN (3) | CN101880283B (ko) |
AR (1) | AR040500A1 (ko) |
AT (2) | ATE505471T1 (ko) |
AU (2) | AU2003254017A1 (ko) |
BR (2) | BRPI0312940B1 (ko) |
CA (2) | CA2492665A1 (ko) |
CO (1) | CO5680407A2 (ko) |
CY (1) | CY1112628T1 (ko) |
DE (1) | DE60336732D1 (ko) |
DK (1) | DK1534290T3 (ko) |
ES (1) | ES2377963T3 (ko) |
GE (2) | GEP20074213B (ko) |
HK (1) | HK1072545A1 (ko) |
HR (2) | HRP20050059B8 (ko) |
IL (3) | IL166129A0 (ko) |
IS (2) | IS7646A (ko) |
MX (2) | MXPA05000716A (ko) |
MY (1) | MY134848A (ko) |
NO (2) | NO330132B1 (ko) |
NZ (1) | NZ537523A (ko) |
PE (1) | PE20040680A1 (ko) |
PL (2) | PL216663B1 (ko) |
PT (1) | PT1534290E (ko) |
RS (2) | RS20050041A (ko) |
RU (2) | RU2005104818A (ko) |
SI (1) | SI1534290T1 (ko) |
TW (1) | TWI329112B (ko) |
UA (1) | UA82846C2 (ko) |
WO (2) | WO2004009601A1 (ko) |
Families Citing this family (192)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
DE69734871D1 (de) * | 1997-05-30 | 2006-01-19 | St Microelectronics Srl | Verfahren zur Herstellung eines Germanium-implantierten bipolaren Heteroübergangtransistors |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
JP2005529890A (ja) | 2002-04-23 | 2005-10-06 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なアリールケトンピロロトリアジン化合物 |
DK1497019T3 (en) * | 2002-04-23 | 2015-08-03 | Bristol Myers Squibb Co | PYRROLO-TRIAZINANILINE COMPOSITIONS USED AS KINase INHIBITORS |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
PT1767535E (pt) * | 2002-08-23 | 2010-02-24 | Sloan Kettering Inst Cancer | Síntese de epotilonas, respectivos intermediários, análogos e suas utilizações |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
KR20050099525A (ko) | 2003-02-05 | 2005-10-13 | 브리스톨-마이어스 스큅 컴퍼니 | 피롤로트리아진 키나제 억제제의 제조 방법 |
CN103880955A (zh) | 2003-07-18 | 2014-06-25 | 安姆根有限公司 | 肝细胞生长因子的特异性结合物 |
US7102001B2 (en) | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7064203B2 (en) * | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US7102002B2 (en) * | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
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