HRP20050059B1 - Novi inhibitori kinaza - Google Patents
Novi inhibitori kinazaInfo
- Publication number
- HRP20050059B1 HRP20050059B1 HRP20050059AA HRP20050059A HRP20050059B1 HR P20050059 B1 HRP20050059 B1 HR P20050059B1 HR P20050059A A HRP20050059A A HR P20050059AA HR P20050059 A HRP20050059 A HR P20050059A HR P20050059 B1 HRP20050059 B1 HR P20050059B1
- Authority
- HR
- Croatia
- Prior art keywords
- compounds
- formula
- kinases
- useful
- treatment
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000009465 Growth Factor Receptors Human genes 0.000 abstract 2
- 108010009202 Growth Factor Receptors Proteins 0.000 abstract 2
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 abstract 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 abstract 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 abstract 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
Abstract
Predmetni izum se odnosi na spojeve formule (I) i njihove farmaceutski prihvatljive soli. Spojevi formule (I) inhibiraju aktivnost tirozin kinaze receptora faktora rasta kao što su VEGFR-2 i FGFR-1, što ih čini korisnim u liječenju karcinoma. Spojevi formule (I) su također korisni za liječenje drugih oboljenja povezanih sa putevima prijenosa signala koji djeluju preko receptora faktora rasta.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39725602P | 2002-07-19 | 2002-07-19 | |
US44721303P | 2003-02-13 | 2003-02-13 | |
PCT/US2003/022826 WO2004009784A2 (en) | 2002-07-19 | 2003-07-18 | Novel inhibitors of kinases |
Publications (3)
Publication Number | Publication Date |
---|---|
HRP20050059A2 HRP20050059A2 (en) | 2005-04-30 |
HRP20050059B1 true HRP20050059B1 (hr) | 2015-02-27 |
HRP20050059B8 HRP20050059B8 (hr) | 2016-03-25 |
Family
ID=30773005
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20050059A HRP20050059B8 (hr) | 2002-07-19 | 2005-01-19 | Novi inhibitori kinaza |
HR20050058A HRP20050058A2 (en) | 2002-07-19 | 2005-01-19 | Azaindole kinase inhibitors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20050058A HRP20050058A2 (en) | 2002-07-19 | 2005-01-19 | Azaindole kinase inhibitors |
Country Status (33)
Country | Link |
---|---|
US (6) | US6869952B2 (hr) |
EP (3) | EP2280012A3 (hr) |
JP (2) | JP4361485B2 (hr) |
KR (1) | KR100901939B1 (hr) |
CN (3) | CN1315833C (hr) |
AR (1) | AR040500A1 (hr) |
AT (2) | ATE537843T1 (hr) |
AU (2) | AU2003254088B2 (hr) |
BR (2) | BRPI0312940B1 (hr) |
CA (2) | CA2492665A1 (hr) |
CO (1) | CO5680407A2 (hr) |
CY (1) | CY1112628T1 (hr) |
DE (1) | DE60336732D1 (hr) |
DK (1) | DK1534290T3 (hr) |
ES (1) | ES2377963T3 (hr) |
GE (2) | GEP20074124B (hr) |
HK (1) | HK1072545A1 (hr) |
HR (2) | HRP20050059B8 (hr) |
IL (3) | IL166129A0 (hr) |
IS (2) | IS7646A (hr) |
MX (2) | MXPA05000715A (hr) |
MY (1) | MY134848A (hr) |
NO (2) | NO330132B1 (hr) |
NZ (1) | NZ537523A (hr) |
PE (1) | PE20040680A1 (hr) |
PL (2) | PL375352A1 (hr) |
PT (1) | PT1534290E (hr) |
RS (2) | RS52325B (hr) |
RU (2) | RU2005104818A (hr) |
SI (1) | SI1534290T1 (hr) |
TW (1) | TWI329112B (hr) |
UA (1) | UA82846C2 (hr) |
WO (2) | WO2004009601A1 (hr) |
Families Citing this family (193)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
EP0881669B1 (en) * | 1997-05-30 | 2005-12-14 | STMicroelectronics S.r.l. | Manufacturing process of a germanium implanted heterojunction bipolar transistor |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
KR101025675B1 (ko) * | 2002-04-23 | 2011-03-30 | 브리스톨-마이어스 스큅 컴퍼니 | 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물 |
ATE418546T1 (de) | 2002-04-23 | 2009-01-15 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
WO2004018478A2 (en) * | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
AU2004212435A1 (en) | 2003-02-05 | 2004-08-26 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine kinase inhibitors |
CN103880955A (zh) | 2003-07-18 | 2014-06-25 | 安姆根有限公司 | 肝细胞生长因子的特异性结合物 |
US7102001B2 (en) | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
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