CR20210387A - Inhibidores de kif18a - Google Patents

Inhibidores de kif18a

Info

Publication number
CR20210387A
CR20210387A CR20210387A CR20210387A CR20210387A CR 20210387 A CR20210387 A CR 20210387A CR 20210387 A CR20210387 A CR 20210387A CR 20210387 A CR20210387 A CR 20210387A CR 20210387 A CR20210387 A CR 20210387A
Authority
CR
Costa Rica
Prior art keywords
kif18a
compounds
cancer
inhibitors
kif18a inhibitors
Prior art date
Application number
CR20210387A
Other languages
English (en)
Inventor
Ana Elena Minatti
Jian Jeffrey Chen
Kexue Li
Vu Ma
Jonathan Dante Low
Nuria A Tamayo
James Alexander Brown
Liping H Pettus
Mary Catherine Walton
Lei Jia
Matthew Paul Bourbeau
Abhisek Banerjee
Michael J Frohn
Qingyian Liu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR20210387A publication Critical patent/CR20210387A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula (I): (I), como se definen en el presente documento, e intermedios sintéticos de los mismos, que pueden modular la proteína KIF18A alterando de esta forma el proceso del ciclo celular y la proliferación celular para tratar el cáncer y enfermedades relacionadas con cáncer. La invención también incluye composiciones farmacéuticas, que incluyen los compuestos, y métodos para tratar patologías relacionadas con la actividad de KIF18A.
CR20210387A 2018-12-20 2019-12-20 Inhibidores de kif18a CR20210387A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862783061P 2018-12-20 2018-12-20
PCT/US2019/068169 WO2020132648A1 (en) 2018-12-20 2019-12-20 Kif18a inhibitors

Publications (1)

Publication Number Publication Date
CR20210387A true CR20210387A (es) 2021-08-19

Family

ID=69187977

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210387A CR20210387A (es) 2018-12-20 2019-12-20 Inhibidores de kif18a

Country Status (21)

Country Link
US (2) US11236069B2 (es)
EP (1) EP3897852A1 (es)
JP (1) JP7407196B2 (es)
KR (1) KR20210106474A (es)
CN (1) CN113226473A (es)
AR (1) AR117490A1 (es)
AU (1) AU2019403486A1 (es)
BR (1) BR112021011989A2 (es)
CA (1) CA3123871A1 (es)
CL (1) CL2021001634A1 (es)
CO (1) CO2021008224A2 (es)
CR (1) CR20210387A (es)
EA (1) EA202191730A1 (es)
IL (1) IL283639B2 (es)
JO (1) JOP20210154B1 (es)
MA (1) MA54543A (es)
MX (1) MX2021007156A (es)
PE (1) PE20211475A1 (es)
SG (1) SG11202106520VA (es)
UY (1) UY38526A (es)
WO (1) WO2020132648A1 (es)

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US11236069B2 (en) * 2018-12-20 2022-02-01 Amgen Inc. KIF18A inhibitors
US20220056015A1 (en) * 2018-12-20 2022-02-24 Amgen Inc. Kif18a inhibitors
JP2023521802A (ja) * 2020-04-14 2023-05-25 アムジエン・インコーポレーテツド 新生物疾患の処置のためのｋｉｆ１８ａ阻害剤
AU2021370660A1 (en) 2020-10-27 2023-06-08 Amgen Inc. Heterocyclic spiro compounds and methods of use
WO2022232332A1 (en) 2021-04-29 2022-11-03 Amgen Inc. 2-aminobenzothiazole compounds and methods of use thereof
CN117980298A (zh) 2021-06-25 2024-05-03 杭州英创医药科技有限公司 作为kif18a抑制剂的化合物
TW202321213A (zh) 2021-07-21 2023-06-01 美商安進公司 Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式
CA3230123A1 (en) * 2021-08-26 2023-03-02 Derek A. Cogan Spiro indoline inhibitors of kif18a
WO2023088441A1 (zh) 2021-11-19 2023-05-25 微境生物医药科技(上海)有限公司 Kif18a抑制剂
AR128353A1 (es) * 2022-01-26 2024-04-24 Amgen Inc Síntesis de un inhibidor de kif18a
WO2023159086A1 (en) 2022-02-16 2023-08-24 Amgen Inc. Quinazoline compounds and use thereof as inhibtors of mutant kras proteins
WO2023159087A1 (en) 2022-02-16 2023-08-24 Amgen Inc. Quinazoline compounds and use thereof as inhibtors of mutant kras proteins
WO2023174175A1 (zh) * 2022-03-17 2023-09-21 微境生物医药科技(上海)有限公司 Kif18a抑制剂
CN116903605A (zh) * 2022-04-15 2023-10-20 武汉人福创新药物研发中心有限公司 一种kif18a抑制剂及其用途
CN116554151A (zh) * 2022-05-13 2023-08-08 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2023217233A1 (zh) * 2022-05-13 2023-11-16 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2024002328A1 (zh) * 2022-06-30 2024-01-04 勤浩医药（苏州）有限公司 一种含氮化合物及其应用
WO2024032661A1 (zh) * 2022-08-11 2024-02-15 山东轩竹医药科技有限公司 Kif18a抑制剂及其用途
WO2024035950A1 (en) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibitors of kif18a and uses thereof
WO2024039829A1 (en) * 2022-08-18 2024-02-22 Accent Therapeutics, Inc. Inhibitors of kif18a and uses thereof
WO2024051755A1 (zh) * 2022-09-08 2024-03-14 长春金赛药业有限责任公司 Kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024051812A1 (zh) * 2022-09-09 2024-03-14 先声再明医药有限公司 酰胺类化合物、其组合物及用途
WO2024067675A1 (zh) * 2022-09-30 2024-04-04 长春金赛药业有限责任公司 稠环类kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024067465A1 (zh) * 2022-09-30 2024-04-04 山东轩竹医药科技有限公司 Kif18a抑制剂
CN117917405A (zh) * 2022-10-21 2024-04-23 杭州邦顺制药有限公司 Kif18a蛋白抑制剂
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CN115594664B (zh) * 2022-11-25 2023-02-24 英矽智能科技(上海)有限公司 一类螺环衍生物作为kif18a抑制剂
WO2024114730A1 (zh) * 2022-11-30 2024-06-06 微境生物医药科技(上海)有限公司 一种用于癌症治疗的药物组合物
WO2024114787A1 (zh) * 2022-12-02 2024-06-06 深圳众格生物科技有限公司 酰胺或脲类化合物
WO2024125488A1 (zh) * 2022-12-14 2024-06-20 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
WO2024125626A1 (en) * 2022-12-16 2024-06-20 Nuphase Therapeutics (Hangzhou) Limited., Co. Nitrogenous compound, pharmaceutical composition and use thereof
CN115947717B (zh) * 2023-03-09 2023-05-30 英矽智能科技(上海)有限公司 一类kif18a抑制剂
CN116535400A (zh) * 2023-04-26 2023-08-04 上海湃隆生物科技有限公司 氮杂螺环化合物及其应用

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