AR128353A1 - Síntesis de un inhibidor de kif18a - Google Patents
Síntesis de un inhibidor de kif18aInfo
- Publication number
- AR128353A1 AR128353A1 ARP230100178A ARP230100178A AR128353A1 AR 128353 A1 AR128353 A1 AR 128353A1 AR P230100178 A ARP230100178 A AR P230100178A AR P230100178 A ARP230100178 A AR P230100178A AR 128353 A1 AR128353 A1 AR 128353A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- kif18a
- inhibitor
- synthesis
- salt
- Prior art date
Links
- 101001091231 Homo sapiens Kinesin-like protein KIF18A Proteins 0.000 title abstract 2
- 229940126262 KIF18A Drugs 0.000 title abstract 2
- 102100034895 Kinesin-like protein KIF18A Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- IGVKWAAPMVVTFX-BUHFOSPRSA-N (e)-octadec-5-en-7,9-diynoic acid Chemical compound CCCCCCCCC#CC#C\C=C\CCCC(O)=O IGVKWAAPMVVTFX-BUHFOSPRSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- FANCTJAFZSYTIS-IQUVVAJASA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-7a-methyl-1-[(2r)-4-(phenylsulfonimidoyl)butan-2-yl]-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCCC(/[C@@H]2CC1)=C\C=C\1C([C@@H](O)C[C@H](O)C/1)=C)C)CS(=N)(=O)C1=CC=CC=C1 FANCTJAFZSYTIS-IQUVVAJASA-N 0.000 abstract 2
- YLEIFZAVNWDOBM-ZTNXSLBXSA-N ac1l9hc7 Chemical compound C([C@H]12)C[C@@H](C([C@@H](O)CC3)(C)C)[C@@]43C[C@@]14CC[C@@]1(C)[C@@]2(C)C[C@@H]2O[C@]3(O)[C@H](O)C(C)(C)O[C@@H]3[C@@H](C)[C@H]12 YLEIFZAVNWDOBM-ZTNXSLBXSA-N 0.000 abstract 2
- 229940125898 compound 5 Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- GVOISEJVFFIGQE-YCZSINBZSA-N n-[(1r,2s,5r)-5-[methyl(propan-2-yl)amino]-2-[(3s)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide Chemical compound CC(=O)N[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1C(=O)[C@@H](NC=2C3=CC(=CC=C3N=CN=2)C(F)(F)F)CC1 GVOISEJVFFIGQE-YCZSINBZSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
Abstract
La presente invención se refiere a la preparación mejorada de un inhibidor de KIF18A que tiene la siguiente estructura química: (Compuesto 1), o una sal de este (Compuesto 1a); donde HA es tal como se define en el presente documento; e intermedios clave de este, es decir, el Compuesto 2a, Compuesto 3a, Compuesto 5 o una sal de este, y Compuesto 6a o un hidrato de este, de fórmulas: (Compuesto 2a); (Compuesto 3a); (Compuesto 5) o una sal de este; y (Compuesto 6a) o un hidrato de este, preferentemente (Compuesto 6a-I). La presente invención se refiere además a una forma sólida del Compuesto 6a, preferentemente la forma cristalina hidratada del Compuesto 6a-I.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202263303470P | 2022-01-26 | 2022-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR128353A1 true AR128353A1 (es) | 2024-04-24 |
Family
ID=85328813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP230100178A AR128353A1 (es) | 2022-01-26 | 2023-01-26 | Síntesis de un inhibidor de kif18a |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR128353A1 (es) |
TW (1) | TW202342451A (es) |
WO (1) | WO2023146973A1 (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA202191730A1 (ru) * | 2018-12-20 | 2021-08-24 | Эмджен Инк. | Ингибиторы kif18a |
JP2023521802A (ja) * | 2020-04-14 | 2023-05-25 | アムジエン・インコーポレーテツド | 新生物疾患の処置のためのkif18a阻害剤 |
-
2023
- 2023-01-26 AR ARP230100178A patent/AR128353A1/es unknown
- 2023-01-26 WO PCT/US2023/011636 patent/WO2023146973A1/en unknown
- 2023-01-30 TW TW112103047A patent/TW202342451A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW202342451A (zh) | 2023-11-01 |
WO2023146973A1 (en) | 2023-08-03 |
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